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Gene Review

CYB5  -  Cyb5p

Saccharomyces cerevisiae S288c

Synonyms: Cytochrome b5, N1949, YNL111C
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Disease relevance of CYB5


High impact information on CYB5


Biological context of CYB5


Anatomical context of CYB5


Associations of CYB5 with chemical compounds


Other interactions of CYB5

  • Synthesis of monohydroxylated inositolphosphorylceramide (IPC-C) in Saccharomyces cerevisiae requires Scs7p, a protein with both a cytochrome b5-like domain and a hydroxylase/desaturase domain [15].

Analytical, diagnostic and therapeutic context of CYB5


  1. Cloning and characterization of a yeast cytochrome b5-encoding gene which suppresses ketoconazole hypersensitivity in a NADPH-P-450 reductase-deficient strain. Truan, G., Epinat, J.C., Rougeulle, C., Cullin, C., Pompon, D. Gene (1994) [Pubmed]
  2. Fah1p, a Saccharomyces cerevisiae cytochrome b5 fusion protein, and its Arabidopsis thaliana homolog that lacks the cytochrome b5 domain both function in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids. Mitchell, A.G., Martin, C.E. J. Biol. Chem. (1997) [Pubmed]
  3. Three-dimensional structure of flavocytochrome b2 from baker's yeast at 3.0-A resolution. Xia, Z.X., Shamala, N., Bethge, P.H., Lim, L.W., Bellamy, H.D., Xuong, N.H., Lederer, F., Mathews, F.S. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  4. Dap1p, a heme-binding protein that regulates the cytochrome P450 protein Erg11p/Cyp51p in Saccharomyces cerevisiae. Mallory, J.C., Crudden, G., Johnson, B.L., Mo, C., Pierson, C.A., Bard, M., Craven, R.J. Mol. Cell. Biol. (2005) [Pubmed]
  5. Identification and functional characterization of the moss Physcomitrella patens delta5-desaturase gene involved in arachidonic and eicosapentaenoic acid biosynthesis. Kaewsuwan, S., Cahoon, E.B., Perroud, P.F., Wiwat, C., Panvisavas, N., Quatrano, R.S., Cove, D.J., Bunyapraphatsara, N. J. Biol. Chem. (2006) [Pubmed]
  6. Disruption of the Candida albicans CYB5 gene results in increased azole sensitivity. Rogers, K.M., Pierson, C.A., Culbertson, N.T., Mo, C., Sturm, A.M., Eckstein, J., Barbuch, R., Lees, N.D., Bard, M. Antimicrob. Agents Chemother. (2004) [Pubmed]
  7. Biodiversity of the P450 catalytic cycle: yeast cytochrome b5/NADH cytochrome b5 reductase complex efficiently drives the entire sterol 14-demethylation (CYP51) reaction. Lamb, D.C., Kelly, D.E., Manning, N.J., Kaderbhai, M.A., Kelly, S.L. FEBS Lett. (1999) [Pubmed]
  8. Functional cloning, based on azole resistance in Saccharomyces cerevisiae, and characterization of Rhizopus nigricans redox carriers that are differentially involved in the P450-dependent response to progesterone stress. Kunic, B., Truan, G., Breskvar, K., Pompon, D. Mol. Genet. Genomics (2001) [Pubmed]
  9. Replacements of lysine 32 in yeast cytochrome c. Effects on the binding and reactivity with physiological partners. Das, G., Hickey, D.R., Principio, L., Conklin, K.T., Short, J., Miller, J.R., McLendon, G., Sherman, F. J. Biol. Chem. (1988) [Pubmed]
  10. Purification and characterization of intact cytochrome b5 from yeast microsomes. Yoshida, Y., Tamura-Higashimaki, Y., Sato, R. Arch. Biochem. Biophys. (1983) [Pubmed]
  11. Expression of cytochrome b5 in yeast and characterization of mutants of the membrane-anchoring domain. Vergères, G., Waskell, L. J. Biol. Chem. (1992) [Pubmed]
  12. A model system for studying membrane biogenesis. Overexpression of cytochrome b5 in yeast results in marked proliferation of the intracellular membrane. Vergères, G., Yen, T.S., Aggeler, J., Lausier, J., Waskell, L. J. Cell. Sci. (1993) [Pubmed]
  13. Coexpression of genetically engineered fused enzyme between yeast NADPH-P450 reductase and human cytochrome P450 3A4 and human cytochrome b5 in yeast. Hayashi, K., Sakaki, T., Kominami, S., Inouye, K., Yabusaki, Y. Arch. Biochem. Biophys. (2000) [Pubmed]
  14. Mutant and immunochemical studies on the involvement of cytochrome b5 in fatty acid desaturation by yeast microsomes. Ohba, M., Sato, R., Yoshida, Y., Bieglmayer, C., Ruis, H. Biochim. Biophys. Acta (1979) [Pubmed]
  15. Synthesis of monohydroxylated inositolphosphorylceramide (IPC-C) in Saccharomyces cerevisiae requires Scs7p, a protein with both a cytochrome b5-like domain and a hydroxylase/desaturase domain. Dunn, T.M., Haak, D., Monaghan, E., Beeler, T.J. Yeast (1998) [Pubmed]
  16. Complete amino acid sequence of the heme-binding core in bakers' yeast cytochrome b2 (L-(+)-lactate dehydrogenase). Guiard, B., Lederer, F. Biochimie (1976) [Pubmed]
  17. Gene2Oligo: oligonucleotide design for in vitro gene synthesis. Rouillard, J.M., Lee, W., Truan, G., Gao, X., Zhou, X., Gulari, E. Nucleic Acids Res. (2004) [Pubmed]
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