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Gene Review

GLY1  -  threonine aldolase GLY1

Saccharomyces cerevisiae S288c

Synonyms: Low specificity L-TA, Low specificity L-threonine aldolase, SYGP-ORF34, TA, YEL046C
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Disease relevance of GLY1


High impact information on GLY1


Chemical compound and disease context of GLY1


Biological context of GLY1


Associations of GLY1 with chemical compounds


  1. Glycine metabolism in Candida albicans: characterization of the serine hydroxymethyltransferase (SHM1, SHM2) and threonine aldolase (GLY1) genes. McNeil, J.B., Flynn, J., Tsao, N., Monschau, N., Stahmann, K., Haynes, R.H., McIntosh, E.M., Pearlman, R.E. Yeast (2000) [Pubmed]
  2. The GLY1 gene of Saccharomyces cerevisiae encodes a low-specific L-threonine aldolase that catalyzes cleavage of L-allo-threonine and L-threonine to glycine--expression of the gene in Escherichia coli and purification and characterization of the enzyme. Liu, J.Q., Nagata, S., Dairi, T., Misono, H., Shimizu, S., Yamada, H. Eur. J. Biochem. (1997) [Pubmed]
  3. Gene cloning, nucleotide sequencing, and purification and characterization of the low-specificity L-threonine aldolase from Pseudomonas sp. strain NCIMB 10558. Liu, J.Q., Ito, S., Dairi, T., Itoh, N., Kataoka, M., Shimizu, S., Yamada, H. Appl. Environ. Microbiol. (1998) [Pubmed]
  4. Unassisted translocation of large polypeptide domains across phospholipid bilayers. Brambillasca, S., Yabal, M., Makarow, M., Borgese, N. J. Cell Biol. (2006) [Pubmed]
  5. Cloning and molecular characterization of three genes, including two genes encoding serine hydroxymethyltransferases, whose inactivation is required to render yeast auxotrophic for glycine. McNeil, J.B., McIntosh, E.M., Taylor, B.V., Zhang, F.R., Tang, S., Bognar, A.L. J. Biol. Chem. (1994) [Pubmed]
  6. Overproduction of threonine aldolase circumvents the biosynthetic role of pyruvate decarboxylase in glucose-limited chemostat cultures of Saccharomyces cerevisiae. van Maris, A.J., Luttik, M.A., Winkler, A.A., van Dijken, J.P., Pronk, J.T. Appl. Environ. Microbiol. (2003) [Pubmed]
  7. L-allo-threonine aldolase from Aeromonas jandaei DK-39: gene cloning, nucleotide sequencing, and identification of the pyridoxal 5'-phosphate-binding lysine residue by site-directed mutagenesis. Liu, J.Q., Dairi, T., Kataoka, M., Shimizu, S., Yamada, H. J. Bacteriol. (1997) [Pubmed]
  8. Threonine aldolase overexpression plus threonine supplementation enhanced riboflavin production in Ashbya gossypii. Monschau, N., Sahm, H., Stahmann, K. Appl. Environ. Microbiol. (1998) [Pubmed]
  9. Identification of Saccharomyces cerevisiae GLY1 as a threonine aldolase: a key enzyme in glycine biosynthesis. Monschau, N., Stahmann, K.P., Sahm, H., McNeil, J.B., Bognar, A.L. FEMS Microbiol. Lett. (1997) [Pubmed]
  10. Disruption of cytoplasmic and mitochondrial folylpolyglutamate synthetase activity in Saccharomyces cerevisiae. DeSouza, L., Shen, Y., Bognar, A.L. Arch. Biochem. Biophys. (2000) [Pubmed]
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