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Gene Review

STX10  -  syntaxin 10

Homo sapiens

Synonyms: SYN10, Syn10, Syntaxin-10, hsyn10
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Disease relevance of STX10


Psychiatry related information on STX10


High impact information on STX10


Biological context of STX10


Anatomical context of STX10

  • Syntaxin 10: a member of the syntaxin family localized to the trans-Golgi network [5].
  • Thus, the results of this study are consistent with those of WHO Workshop evaluations that seem to suggest that STX-10 is a highly gamete-specific antigen localized on the inner acrosome of human sperm and in human trophoblast/placenta [4].

Other interactions of STX10

  • Therefore, in spite of its co-localization and possible interaction with syntaxin 16, syntaxin 10 is not part of the syntaxin 16-based SNARE complex involved in endosome-TGN transport, and may have a hitherto unrecognized function in the TGN-endosome boundary [3].

Analytical, diagnostic and therapeutic context of STX10

  • The cognate antigen, designated as STX-10, was found to exist as an aggregate in the native form when analyzed by Sephacryl S-300 gel filtration chromatography [4].


  1. Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1. Martín-Martín, B., Nabokina, S.M., Lazo, P.A., Mollinedo, F. J. Leukoc. Biol. (1999) [Pubmed]
  2. Narcotic antagonists in drug dependence: pilot study showing enhancement of compliance with SYN-10, amino-acid precursors and enkephalinase inhibition therapy. Chen, T.J., Blum, K., Payte, J.T., Schoolfield, J., Hopper, D., Stanford, M., Braverman, E.R. Med. Hypotheses (2004) [Pubmed]
  3. Trans-Golgi network syntaxin 10 functions distinctly from syntaxins 6 and 16. Wang, Y., Tai, G., Lu, L., Johannes, L., Hong, W., Luen Tang, B. Mol. Membr. Biol. (2005) [Pubmed]
  4. Studies of a sperm/placenta cross-reacting antigen, STX-10. Lee, C.Y., Hsiao, L., Yang, Y.Y., Chow, S., Chao, H.T., Ng, H.T., Wong, E., Sun, A., Hsu, E. J. Reprod. Immunol. (1993) [Pubmed]
  5. Syntaxin 10: a member of the syntaxin family localized to the trans-Golgi network. Tang, B.L., Low, D.Y., Tan, A.E., Hong, W. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
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