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Gene Review

furA  -  ferric uptake regulation protein FurA

Mycobacterium tuberculosis H37Rv

 
 
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Disease relevance of furA

 

High impact information on furA

  • Interestingly, a furA-lacking strain induced the complex at lower concentrations of INH compared with the control strain, whereas higher INH concentrations were necessary to induce the complex in a strain that lacks katG, suggesting that INH needs to be activated by KatG to induce the KasA-containing complex [2].
  • No promoter activity was demonstrated downstream of the furA start codon, using different gene reporter systems, indicating that furA and katG are co-transcribed from a common regulatory region [1].
  • In this work we analyzed the M. tuberculosis furA promoter region [3].
  • The Mycobacterium tuberculosis genome encodes two ferric uptake regulator homologues, furA and furB, the function of which is under investigation [4].
 

Biological context of furA

 

Associations of furA with chemical compounds

  • In the absence of furA, katG was upregulated, cells became hypersensitive to isoniazid, and full virulence was restored, indicating that furA regulates the transcription of both genes [1].
 

Regulatory relationships of furA

  • This association suggested that furA might regulate katG and other genes involved in pathogenesis [1].
 

Other interactions of furA

  • Transcript mapping showed katG to be expressed from a strong promoter, with consensus -10 and -35 elements, preceding furA [1].
 

Analytical, diagnostic and therapeutic context of furA

References

  1. Regulation of catalase-peroxidase (KatG) expression, isoniazid sensitivity and virulence by furA of Mycobacterium tuberculosis. Pym, A.S., Domenech, P., Honoré, N., Song, J., Deretic, V., Cole, S.T. Mol. Microbiol. (2001) [Pubmed]
  2. Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria. Kremer, L., Dover, L.G., Morbidoni, H.R., Vilchèze, C., Maughan, W.N., Baulard, A., Tu, S.C., Honoré, N., Deretic, V., Sacchettini, J.C., Locht, C., Jacobs, W.R., Besra, G.S. J. Biol. Chem. (2003) [Pubmed]
  3. Mycobacterium tuberculosis FurA autoregulates its own expression. Sala, C., Forti, F., Di Florio, E., Canneva, F., Milano, A., Riccardi, G., Ghisotti, D. J. Bacteriol. (2003) [Pubmed]
  4. The Mycobacterium tuberculosis Rv2358-furB operon is induced by zinc. Milano, A., Branzoni, M., Canneva, F., Profumo, A., Riccardi, G. Res. Microbiol. (2004) [Pubmed]
  5. Transcriptional regulation of furA and katG upon oxidative stress in Mycobacterium smegmatis. Milano, A., Forti, F., Sala, C., Riccardi, G., Ghisotti, D. J. Bacteriol. (2001) [Pubmed]
 
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