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Gene Review

SLC7A6  -  solute carrier family 7 (amino acid...

Homo sapiens

Synonyms: Cationic amino acid transporter, y+ system, KIAA0245, LAT-2, LAT3, Solute carrier family 7 member 6, ...
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High impact information on SLC7A6

  • Human LAT4 exhibits 57% identity to human LAT3 [1].
  • Expression of tagged N-myc-LAT-2 alone in oocytes did not induce amino acid transport, and the protein had an intracellular location [2].
  • Human LAT-2 mRNA is expressed in kidney >>> placenta >> brain, liver > spleen, skeletal muscle, heart, small intestine, and lung [2].
  • Human LAT-2 gene localizes at chromosome 14q11.2-13 (13 cR or approximately 286 kb from marker D14S1349) [2].
  • The high expression of LAT-2 mRNA in epithelial cells of proximal tubules, the basolateral location of 4F2hc in these cells, and the amino acid transport activity of LAT-2 suggest that this transporter contributes to the renal reabsorption of neutral amino acids in the basolateral domain of epithelial proximal tubule cells [2].

Biological context of SLC7A6


Anatomical context of SLC7A6

  • We conclude that LPI fibroblasts exhibit normal CAA transport through system y(+)L, probably referable to the activity of SLC7A6/y+LAT2 [4].
  • By contrast, system B(0+), associated with system y(+)L (SLC3A2/SLC7A7 and SLC7A6), made a major contribution to the transport of cationic amino acids in pachytene spermatocytes and early spermatids [5].
  • Carboxy terminal truncations and site specific mutants of 4F2hc were co-expressed in Xenopus laevis oocytes with the y+ LAT2 light chain, and the oocytes were analysed for transport activity and surface expression [6].
  • The expression of LAT1 mRNA was 100- and 15-fold greater than that of LAT2 in TR-iBRB2 and magnetically isolated rat retinal vascular endothelial cells, respectively [7].
  • Na+-independent transporters, LAT-2 and b0,+, exchange L-DOPA with neutral and basic amino acids in two clonal renal cell lines [8].

Associations of SLC7A6 with chemical compounds


Other interactions of SLC7A6


  1. Identification of LAT4, a novel amino acid transporter with system L activity. Bodoy, S., Martín, L., Zorzano, A., Palacín, M., Estévez, R., Bertran, J. J. Biol. Chem. (2005) [Pubmed]
  2. Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids. Pineda, M., Fernández, E., Torrents, D., Estévez, R., López, C., Camps, M., Lloberas, J., Zorzano, A., Palacín, M. J. Biol. Chem. (1999) [Pubmed]
  3. Five novel SLC7A7 variants and y+L gene-expression pattern in cultured lymphoblasts from Japanese patients with lysinuric protein intolerance. Shoji, Y., Noguchi, A., Shoji, Y., Matsumori, M., Takasago, Y., Takayanagi, M., Yoshida, Y., Ihara, K., Hara, T., Yamaguchi, S., Yoshino, M., Kaji, M., Yamamoto, S., Nakai, A., Koizumi, A., Hokezu, Y., Nagamatsu, K., Mikami, H., Kitajima, I., Takada, G. Hum. Mutat. (2002) [Pubmed]
  4. Arginine transport through system y(+)L in cultured human fibroblasts: normal phenotype of cells from LPI subjects. Dall'Asta, V., Bussolati, O., Sala, R., Rotoli, B.M., Sebastio, G., Sperandeo, M.P., Andria, G., Gazzola, G.C. Am. J. Physiol., Cell Physiol. (2000) [Pubmed]
  5. Multiple pathways for cationic amino Acid transport in rat seminiferous tubule cells. Cérec, V., Piquet-Pellorce, C., Aly, H.A., Touzalin, A.M., Jégou, B., Bauché, F. Biol. Reprod. (2007) [Pubmed]
  6. Mutation of the 4F2 heavy-chain carboxy terminus causes y+ LAT2 light-chain dysfunction. Chubb, S., Kingsland, A.L., Bröer, A., Bröer, S. Mol. Membr. Biol. (2006) [Pubmed]
  7. L-type amino acid transporter 1-mediated L-leucine transport at the inner blood-retinal barrier. Tomi, M., Mori, M., Tachikawa, M., Katayama, K., Terasaki, T., Hosoya, K. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  8. Na+-independent transporters, LAT-2 and b0,+, exchange L-DOPA with neutral and basic amino acids in two clonal renal cell lines. Gomes, P., Soares-da-Silva, P. J. Membr. Biol. (2002) [Pubmed]
  9. Role of the System L permease LAT1 in amino acid and iodothyronine transport in placenta. Ritchie, J.W., Taylor, P.M. Biochem. J. (2001) [Pubmed]
  10. In vitro polarized transport of L-phenylalanine in human nasal epithelium and partial characterization of the amino acid transporters involved. Agu, R., Dang, H.V., Jorissen, M., Willems, T., Vandoninck, S., Van Lint, J., Vandenheede, J.V., Kinget, R., Verbeke, N. Pharm. Res. (2003) [Pubmed]
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