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Gene Review

CD3E  -  CD3e molecule, epsilon (CD3-TCR complex)

Homo sapiens

Synonyms: IMD18, T-cell surface antigen T3/Leu-4 epsilon chain, T-cell surface glycoprotein CD3 epsilon chain, T3E, TCRE
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Disease relevance of CD3E

  • SUMMARY: Two new severe combined immunodeficiency conditions have been reported as a consequence of either CD3D or CD3E deficiency [1].
  • We estimated the possibility of T3E as a new anticancer agent against lung adenocarcinoma showing poor prognosis based on the mutation of ras gene [2].
  • CONCLUSIONS: Resection of a submucous adenoma increases the risk of fluid absorption during TCRE [3].
  • Dysmenorrhea disappeared in half the patients, while 17% of those who were pain-free before the TCRE had developed cyclic pelvic pain at 1 year, an outcome also associated with a larger fluid absorption (p<0.02) [3].
  • RESULTS: Fluid absorption was increased in patients treated with a GnRH analogue (leuprolide acetate) prior to the TCRE (p<0.007) and also when a submucous myoma was removed during the operation (p<0.0001) [3].

High impact information on CD3E

  • Patients and affected fetuses from 2 families were homozygous for a mutation in the CD3D gene, and patients from the third family were homozygous for a mutation in the CD3E gene [4].
  • A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3E gene [5].
  • T3E showed cytotoxicity against A549 cells, a human lung adenocarcinoma cell line with a ras gene mutation, in a dose-dependent manner (0-40 microM), whereas T3 and a redox-silent analogue of alpha-tocopherol (T), 6-O-carboxypropyl-alpha-tocopherol (TE), showed much less cytotoxicity in cells within 40 microM [2].
  • Our results suggest that T3E suppresses Ras and RhoA prenylation, leading to negative growth control against A549 cells [2].
  • Moreover, the T3E-dependent inhibition of RhoA geranyl-geranylation is an inducing factor for the occurrence of apoptosis in A549 cells [2].

Biological context of CD3E


Anatomical context of CD3E


Associations of CD3E with chemical compounds

  • To overcome the disadvantage and reinforce the anticancer activity in tocotrienols, we synthesized a redox-silent analogue of alpha-tocotrienol (T3), 6-O-carboxypropyl-alpha-tocotrienol (T3E) [2].
  • METHOD: Two hunded and sixty-five women underwent TCRE in which the absorption of irrigating fluid (glycine 1.5%) was measured volumetrically [3].

Other interactions of CD3E

  • Putative candidate genes mapping close to the 19 novel markers include the IL10RA and CD3E genes on 11q23 (which both lie close to the marker D11S1998) [7].

Analytical, diagnostic and therapeutic context of CD3E

  • The odds of fluid overload and equipment failure were higher ((OR=5.2, 95% CI 1.5, 18.4) and (OR=6.0, 95% CI 1.7, 20.9) respectively) for those women having laser as compared to TCRE (transcervical resection of the endometriuim) [8].


  1. CD3 deficiencies. Fischer, A., de Saint Basile, G., Le Deist, F. Current opinion in allergy and clinical immunology. (2005) [Pubmed]
  2. Induction of cytotoxicity in human lung adenocarcinoma cells by 6-O-carboxypropyl-alpha-tocotrienol, a redox-silent derivative of alpha-tocotrienol. Yano, Y., Satoh, H., Fukumoto, K., Kumadaki, I., Ichikawa, T., Yamada, K., Hagiwara, K., Yano, T. Int. J. Cancer (2005) [Pubmed]
  3. Fluid absorption and the long-term outcome after transcervical resection of the endometrium. Steffensen, A.J., Hahn, R.G. Acta obstetricia et gynecologica Scandinavica. (1998) [Pubmed]
  4. Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3. de Saint Basile, G., Geissmann, F., Flori, E., Uring-Lambert, B., Soudais, C., Cavazzana-Calvo, M., Durandy, A., Jabado, N., Fischer, A., Le Deist, F. J. Clin. Invest. (2004) [Pubmed]
  5. A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3E gene. Wang, B., Biron, C., She, J., Higgins, K., Sunshine, M.J., Lacy, E., Lonberg, N., Terhorst, C. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  6. Analysis of the CD3 gene region and type 1 diabetes: application of fluorescence-based technology to linkage disequilibrium mapping. Pritchard, L.E., Kawaguchi, Y., Reed, P.W., Copeman, J.B., Davies, J.L., Barnett, A.H., Bain, S.C., Todd, J.A. Hum. Mol. Genet. (1995) [Pubmed]
  7. A genome wide scan for association with multiple sclerosis in a N. Irish case control population. Heggarty, S., Sawcer, S., Hawkins, S., McDonnell, G., Droogan, A., Vandenbroeck, K., Hutchinson, M., Setakis, E., Compston, A., Graham, C. J. Neuroimmunol. (2003) [Pubmed]
  8. Endometrial destruction techniques for heavy menstrual bleeding. Lethaby, A., Hickey, M. Cochrane database of systematic reviews (Online) (2002) [Pubmed]
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