Disease relevance of Pelvic Pain

• Those factors which correlated with a significant decrease in five-year survival were abnormal admission blood urea nitrogen level or excretory urogram, a history of pelvic pain or weight loss over 10 kg (20 lbs.), or tumor extension to the endocervix or uterus [1].
• Treatment of chronic prostatitis/chronic pelvic pain syndrome with tamsulosin: a randomized double blind trial [2].
• Blood was collected from 61 patients undergoing laparoscopy for pelvic pain, infertility, or tubal ligation [3].
• PURPOSE: We examined bladder biopsies from women with interstitial cystitis/chronic pelvic pain syndrome (IC/CPPS) for the presence of bacterial and viral DNA sequences using polymerase chain reaction [4].
• OBJECTIVE: To obtain estimates of the effects of progestin treatment for pelvic pain associated with endometriosis [5].

Psychiatry related information on Pelvic Pain

• Twenty-five patients, with ages ranging from 25-55 years old, complaining of mild to severe pelvic pain and dyspareunia seeking treatment in our OPD were evaluated and treated in a span of 3 years' time [6].
• Co-existing prostatitis/male pelvic pain, erectile dysfunction, PDE5 inhibitor use and anxiety were high [7].

High impact information on Pelvic Pain

• Relaxin levels in patients with pelvic pain were close to normal non-pregnant levels by the third postnatal day [8].
• The clinical effectiveness of chronic progestin treatment in endometriosis-associated pelvic pain may be attributed to its inhibition of RANTES production and its suppression of inflammatory responses in the pelvis [9].
• Venlafaxine XR and chronic pelvic pain syndrome [10].
• Imaging evaluation of acute right lower quadrant and pelvic pain in adolescent girls. American College of Radiology. ACR Appropriateness Criteria [11].
• In 2 patients, the effects of the morphine sulfate on their unilateral pelvic pain wore off after 4 and 6 months because of tumor progression [12].

Chemical compound and disease context of Pelvic Pain

• Pentosan polysulfate sodium therapy for men with chronic pelvic pain syndrome: a multicenter, randomized, placebo controlled study [13].
• Urinary urgency and frequency, and chronic urethral and/or pelvic pain in females. Can doxycycline help [14]?
• CONCLUSIONS: Terazosin proved superior to placebo for patients with chronic prostatitis/chronic pelvic pain syndrome who had not received alpha-blockers previously [15].
• Intravesical potassium chloride sensitivity test in men with chronic pelvic pain syndrome [16].
• Calcitonin gene-related peptide (CGRP) and substance P (SP) in dual labeled cells were determined by immunohistochemistry, giving possible insight into the cause of pelvic pain [17].

Biological context of Pelvic Pain

• Anti-inflammatory phytotherapy failure was associated with low TNF-alpha and high IL-10 phenotypes, which may help define a subset of patients with the chronic pelvic pain syndrome without an inflammatory etiology [18].
• PF IL-15 levels demonstrated little variation during the menstrual cycle, and did not discriminate between women with infertility or pelvic pain [19].
• Peritoneal fluid IL-18 levels were significantly higher in the luteal phase than in the follicular phase but did not discriminate between women with pelvic pain or infertility [20].
• A total of 55 fertile patients with pelvic pain who had endometriosis diagnosed by laparoscopy and confirmed by histology formed the study group, while 43 fertile patients without pelvic pain and undergoing tubal sterilization formed the control group [21].
• CASE: A previously asymptomatic woman presented with pelvic pain and vaginal bleeding at 4 months' gestation and was found to have a live, 14-week, tubal pregnancy [22].

Anatomical context of Pelvic Pain

• Following chemoradiation, both patients developed pelvic pain and an elevation of C-reactive protein (CRP) in the presence of a normal leukocyte count [23].
• METHODS: Chemotactic index of peripheral blood polymorphonuclear leukocytes, natural killer cell activity, and plasma estradiol (E2) and plasma prostaglandin (PG) E2 levels were evaluated in 46 women who underwent laparoscopy or laparotomy for pelvic pain, infertility, and/or benign adnexal masses [24].
• CONCLUSION(S): The presence of uric acid crystals in semen of a patient with symptoms of chronic prostatitis can be attributed to the pelvic pain [25].

Gene context of Pelvic Pain

• CONCLUSIONS: Our study suggests that IL-10 may have a role in the pain symptoms experienced by patients with chronic prostatitis-chronic pelvic pain syndrome [26].
• In fact, pilot trials showed that aromatase inhibitors could decrease pelvic pain associated with endometriosis [27].
• PSA is a candidate self-antigen in autoimmune chronic prostatitis/chronic pelvic pain syndrome [28].
• BACKGROUND: The purpose of this study was to determine whether psychiatric disturbances, particularly somatization, and an increased number of traumatic and critical life events, which have been found in women with idiopathic chronic pelvic pain (ICPP), can also be observed in women with chronic pelvic pain and abdominal adhesions (ACPP) [29].
• CONCLUSIONS: The existence of a rich TRPV1 sensory innervation in the human prostate may open new therapeutic perspectives for the treatment of pain in patients with chronic prostatitis (Chronic Pelvic Pain Syndrome) [30].

Analytical, diagnostic and therapeutic context of Pelvic Pain

• CONCLUSIONS: The use of mini-hysteroscopes (3.3 mm with diagnostic sheath) lowers considerably the level of pelvic pain the patients feel: it is halved in comparison with traditional calibre hysteroscopes (2.3 +/- 2.1, on a 0-10 VAS) [31].
• CONCLUSION: Treatment with LA depot plus conjugated equine Es and MPA for 2 years was a safe and effective therapy for women with endometriosis and pelvic pain in this small retrospective study [32].
• During the recovery period, both the spring-loaded clip and the tubal ring are associated with higher rates of abdominal or pelvic pain than is electrocoagulation [33].
• Reoperation was indicated by elevated CEA levels in seven patients (70 percent), persistent pelvic pain in six (60 percent), and a suspicious radiologic study in seven (70 percent) [34].
• Indications for surgery included chronic pelvic pain after hysterectomy (N = 5), endometriosis (N = 1), estrogen receptor-positive metastatic breast carcinoma that had not responded to chemotherapy (N = 1), and tuboovarian ectopic pregnancy (N = 1) [35].

References