The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AGN-PC-009MY7     2,5,7,8-tetramethyl-2- (4,8,12...

Synonyms: SureCN2364445, AC1L3NJP, CTK8D6308, LS-173647, C29H44O2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of zeta1-Tocopherol


High impact information on zeta1-Tocopherol


Chemical compound and disease context of zeta1-Tocopherol


Biological context of zeta1-Tocopherol


Anatomical context of zeta1-Tocopherol


Associations of zeta1-Tocopherol with other chemical compounds


Gene context of zeta1-Tocopherol


Analytical, diagnostic and therapeutic context of zeta1-Tocopherol

  • Synthetic alpha-tocotrienol was separated into four geometrical E/Z side chain isomers by preparative HPLC (permethylated beta-cyclodextrin phase) [22].


  1. Induction of cytotoxicity in human lung adenocarcinoma cells by 6-O-carboxypropyl-alpha-tocotrienol, a redox-silent derivative of alpha-tocotrienol. Yano, Y., Satoh, H., Fukumoto, K., Kumadaki, I., Ichikawa, T., Yamada, K., Hagiwara, K., Yano, T. Int. J. Cancer (2005) [Pubmed]
  2. Tocotrienol inhibits proliferation of human Tenon's fibroblasts in vitro: a comparative study with vitamin E forms and mitomycin C. Meyenberg, A., Goldblum, D., Zingg, J.M., Azzi, A., Nesaretnam, K., Kilchenmann, M., Frueh, B.E. Graefes Arch. Clin. Exp. Ophthalmol. (2005) [Pubmed]
  3. Vitamin E deficiency reduced lumbar bone calcium content in female rats. Norazlina, M., Chua, C.W., Ima-Nirwana, S. Med. J. Malaysia (2004) [Pubmed]
  4. Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration. Khanna, S., Roy, S., Ryu, H., Bahadduri, P., Swaan, P.W., Ratan, R.R., Sen, C.K. J. Biol. Chem. (2003) [Pubmed]
  5. Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c-Src) kinase activation and death of HT4 neuronal cells. Sen, C.K., Khanna, S., Roy, S., Packer, L. J. Biol. Chem. (2000) [Pubmed]
  6. Inhibition of THP-1 cell adhesion to endothelial cells by alpha-tocopherol and alpha-tocotrienol is dependent on intracellular concentration of the antioxidants. Noguchi, N., Hanyu, R., Nonaka, A., Okimoto, Y., Kodama, T. Free Radic. Biol. Med. (2003) [Pubmed]
  7. Tocotrienol: the natural vitamin E to defend the nervous system? Sen, C.K., Khanna, S., Roy, S. Ann. N. Y. Acad. Sci. (2004) [Pubmed]
  8. Topical alpha-tocotrienol supplementation inhibits lipid peroxidation but fails to mitigate increased transepidermal water loss after benzoyl peroxide treatment of human skin. Weber, S.U., Thiele, J.J., Han, N., Luu, C., Valacchi, G., Weber, S., Packer, L. Free Radic. Biol. Med. (2003) [Pubmed]
  9. Vitamin E protected cultured cortical neurons from oxidative stress-induced cell death through the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Numakawa, Y., Numakawa, T., Matsumoto, T., Yagasaki, Y., Kumamaru, E., Kunugi, H., Taguchi, T., Niki, E. J. Neurochem. (2006) [Pubmed]
  10. Antiproliferative and apoptotic effects of tocopherols and tocotrienols on preneoplastic and neoplastic mouse mammary epithelial cells. McIntyre, B.S., Briski, K.P., Gapor, A., Sylvester, P.W. Proc. Soc. Exp. Biol. Med. (2000) [Pubmed]
  11. Influence of route of administration on the absorption and disposition of alpha-, gamma- and delta-tocotrienols in rats. Yap, S.P., Yuen, K.H., Lim, A.B. J. Pharm. Pharmacol. (2003) [Pubmed]
  12. Triton WR1339, an Inhibitor of Lipoprotein Lipase, Decreases Vitamin E Concentration in Some Tissues of Rats by Inhibiting Its Transport to Liver. Abe, C., Ikeda, S., Uchida, T., Yamashita, K., Ichikawa, T. J. Nutr. (2007) [Pubmed]
  13. Comparative antioxidant activity of tocotrienols and the novel chromanyl-polyisoprenyl molecule FeAox-6 in isolated membranes and intact cells. Palozza, P., Verdecchia, S., Avanzi, L., Vertuani, S., Serini, S., Iannone, A., Manfredini, S. Mol. Cell. Biochem. (2006) [Pubmed]
  14. Antioxidant systems of the avian embryo: tissue-specific accumulation and distribution of vitamin E in the turkey embryo during development. Surai, P.F., Sparks, N.H., Noble, R.C. Br. Poult. Sci. (1999) [Pubmed]
  15. Protective effect of alpha-tocotrienol against free radical-induced impairment of erythrocyte deformability. Begum, A.N., Terao, J. Biosci. Biotechnol. Biochem. (2002) [Pubmed]
  16. Efficacy of topically applied tocopherols and tocotrienols in protection of murine skin from oxidative damage induced by UV-irradiation. Weber, C., Podda, M., Rallis, M., Thiele, J.J., Traber, M.G., Packer, L. Free Radic. Biol. Med. (1997) [Pubmed]
  17. Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol. Khanna, S., Roy, S., Parinandi, N.L., Maurer, M., Sen, C.K. J. Neurochem. (2006) [Pubmed]
  18. Alpha-tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons. Osakada, F., Hashino, A., Kume, T., Katsuki, H., Kaneko, S., Akaike, A. Neuropharmacology (2004) [Pubmed]
  19. Postprandial levels of the natural vitamin e tocotrienol in human circulation. Khosla, P., Patel, V., Whinter, J.M., Khanna, S., Rakhkovskaya, M., Roy, S., Sen, C.K. Antioxid. Redox Signal. (2006) [Pubmed]
  20. Intracellular mechanisms mediating tocotrienol-induced apoptosis in neoplastic mammary epithelial cells. Sylvester, P.W., Shah, S. Asia Pacific journal of clinical nutrition. (2005) [Pubmed]
  21. Structural and dynamic membrane properties of alpha-tocopherol and alpha-tocotrienol: implication to the molecular mechanism of their antioxidant potency. Suzuki, Y.J., Tsuchiya, M., Wassall, S.R., Choo, Y.M., Govil, G., Kagan, V.E., Packer, L. Biochemistry (1993) [Pubmed]
  22. Determination of RS,E/Z-tocotrienols by HPLC. Drotleff, A.M., Ternes, W. Journal of chromatography. A. (2001) [Pubmed]
WikiGenes - Universities