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Gene Review

IL10RA  -  interleukin 10 receptor, alpha

Homo sapiens

Synonyms: CD210, CD210a, CDW210A, CDw210a, HIL-10R, ...
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Disease relevance of IL10RA


High impact information on IL10RA


Chemical compound and disease context of IL10RA

  • The significance of two SNPs of the interleukin-10 receptor 1 (IL-10R1), S138G (SNP3) and G330R (SNP4) was investigated on (i) susceptibility to CHC, (ii) progression of hepatic fibrosis and (iii) response to interferon/ribavirin therapy [10].

Biological context of IL10RA


Anatomical context of IL10RA


Associations of IL10RA with chemical compounds


Regulatory relationships of IL10RA


Other interactions of IL10RA

  • In contrast, surface IL-10R1 and IL-10 binding activity diminished in mature DCs [29].
  • The second form of interaction requires a motif termed Box 2B, which is present in the IFNgammaRalpha/IFNGR1 (SILLPKS) and IL10Ralpha/IL10R1 (SVLLFKK) chains [30].
  • Putative candidate genes mapping close to the 19 novel markers include the IL10RA and CD3E genes on 11q23 (which both lie close to the marker D11S1998) [31].
  • IL-19 does not bind or signal through the canonical IL-10 receptor complex, suggesting existence of an IL-19 specific receptor complex, the identity of which remains to be discovered [32].
  • Furthermore we could show that IL-4, IFN-gamma, FK506, loratadine and UVA enhance the mRNA levels of the IL-10R1 in vitro in normal cultured keratinocytes [3].

Analytical, diagnostic and therapeutic context of IL10RA


  1. Gene polymorphisms in Toll-like receptors, interleukin-10, and interleukin-10 receptor alpha and lymphoma risk. Nieters, A., Beckmann, L., Deeg, E., Becker, N. Genes Immun. (2006) [Pubmed]
  2. Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1. Jones, B.C., Logsdon, N.J., Josephson, K., Cook, J., Barry, P.A., Walter, M.R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Differential IL-10 receptor gene expression in acute versus chronic atopic eczema. Modulation by immunosuppressive drugs and cytokines in normal cultured keratinocytes. Müschen, A., Mirmohammadsadegh, A., Jarzebska-Deussen, B., Abts, H.F., Ruzicka, T., Michel, G. Inflamm. Res. (1999) [Pubmed]
  4. Novel variants of the IL-10 receptor 1 affect inhibition of monocyte TNF-alpha production. Gasche, C., Grundtner, P., Zwirn, P., Reinisch, W., Shaw, S.H., Zdanov, A., Sarma, U., Williams, L.M., Foxwell, B.M., Gangl, A. J. Immunol. (2003) [Pubmed]
  5. Interleukin-10 is a growth factor for human melanoma cells and down-regulates HLA class-I, HLA class-II and ICAM-1 molecules. Yue, F.Y., Dummer, R., Geertsen, R., Hofbauer, G., Laine, E., Manolio, S., Burg, G. Int. J. Cancer (1997) [Pubmed]
  6. Interleukin-10 determines viral clearance or persistence in vivo. Brooks, D.G., Trifilo, M.J., Edelmann, K.H., Teyton, L., McGavern, D.B., Oldstone, M.B. Nat. Med. (2006) [Pubmed]
  7. Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. Josephson, K., Logsdon, N.J., Walter, M.R. Immunity (2001) [Pubmed]
  8. Inhibition of interleukin 10 signaling after Fc receptor ligation and during rheumatoid arthritis. Ji, J.D., Tassiulas, I., Park-Min, K.H., Aydin, A., Mecklenbrauker, I., Tarakhovsky, A., Pricop, L., Salmon, J.E., Ivashkiv, L.B. J. Exp. Med. (2003) [Pubmed]
  9. Identification and functional characterization of a second chain of the interleukin-10 receptor complex. Kotenko, S.V., Krause, C.D., Izotova, L.S., Pollack, B.P., Wu, W., Pestka, S. EMBO J. (1997) [Pubmed]
  10. Bi-allelic presence of the interleukin-10 receptor 1 G330R allele is associated with cirrhosis in chronic HCV-1 infection. Hofer, H., Neufeld, J.B., Oesterreicher, C., Grundtner, P., Wrba, F., Gangl, A., Ferenci, P., Gasche, C. Genes Immun. (2005) [Pubmed]
  11. Interleukin-10 activation of the interleukin-10E1 pathway and tissue inhibitor of metalloproteinase-1 expression is enhanced by proteasome inhibitors in primary prostate tumor lines. Stearns, M.E., Wang, M., Hu, Y., Garcia, F.U. Mol. Cancer Res. (2003) [Pubmed]
  12. Up-regulation of IL-10R1 expression is required to render human neutrophils fully responsive to IL-10. Crepaldi, L., Gasperini, S., Lapinet, J.A., Calzetti, F., Pinardi, C., Liu, Y., Zurawski, S., de Waal Malefyt, R., Moore, K.W., Cassatella, M.A. J. Immunol. (2001) [Pubmed]
  13. Characterization of recombinant extracellular domain of human interleukin-10 receptor. Tan, J.C., Braun, S., Rong, H., DiGiacomo, R., Dolphin, E., Baldwin, S., Narula, S.K., Zavodny, P.J., Chou, C.C. J. Biol. Chem. (1995) [Pubmed]
  14. Interleukin-10 promoter polymorphism and venous thrombosis: a case-control study. Cochery-Nouvellon, E., Vitry, F., Cornillet-Lefebvre, P., Hezard, N., Gillot, L., Nguyen, P. Thromb. Haemost. (2006) [Pubmed]
  15. Polymorphisms within the interleukin-10 receptor cDNA gene (IL10R) in Japanese patients with systemic lupus erythematosus. Nakashima, H., Akahoshi, M., Tanaka, Y., Yamaoka, K., Ogami, E., Nagano, S., Arinobu, Y., Niiro, H., Otsuka, T., Niho, Y. Rheumatology (Oxford, England) (1999) [Pubmed]
  16. Induction of tumour necrosis factor receptor-expressing macrophages by interleukin-10 and macrophage colony-stimulating factor in rheumatoid arthritis. Takasugi, K., Yamamura, M., Iwahashi, M., Otsuka, F., Yamana, J., Sunahori, K., Kawashima, M., Yamada, M., Makino, H. Arthritis Res. Ther. (2006) [Pubmed]
  17. The functional characterization of interleukin-10 receptor expression on human natural killer cells. Carson, W.E., Lindemann, M.J., Baiocchi, R., Linett, M., Tan, J.C., Chou, C.C., Narula, S., Caligiuri, M.A. Blood (1995) [Pubmed]
  18. CXCL10 production from cytomegalovirus-stimulated microglia is regulated by both human and viral interleukin-10. Cheeran, M.C., Hu, S., Sheng, W.S., Peterson, P.K., Lokensgard, J.R. J. Virol. (2003) [Pubmed]
  19. IL-10 inhibits endothelium-dependent T cell costimulation by up-regulation of ILT3/4 in human vascular endothelial cells. Gleissner, C.A., Zastrow, A., Klingenberg, R., Kluger, M.S., Konstandin, M., Celik, S., Haemmerling, S., Shankar, V., Giese, T., Katus, H.A., Dengler, T.J. Eur. J. Immunol. (2007) [Pubmed]
  20. The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes. Donnelly, R.P., Dickensheets, H., Finbloom, D.S. J. Interferon Cytokine Res. (1999) [Pubmed]
  21. Molecular basis of the synergistic production of IL-1 receptor antagonist by human neutrophils stimulated with IL-4 and IL-10. Crepaldi, L., Silveri, L., Calzetti, F., Pinardi, C., Cassatella, M.A. Int. Immunol. (2002) [Pubmed]
  22. Regulation of adrenal glucocorticoid synthesis by interleukin-10: a preponderance of IL-10 receptor in the adrenal zona fasciculata. Koldzic-Zivanovic, N., Tu, H., Juelich, T.L., Rady, P.L., Tyring, S.K., Hudnall, S.D., Smith, E.M., Hughes, T.K. Brain Behav. Immun. (2006) [Pubmed]
  23. IL-10/IL-10 receptor signaling regulates TIMP-1 expression in primary human prostate tumor lines. Wang, M., Hu, Y., Shima, I., Stearns, M.E. Cancer Biol. Ther. (2002) [Pubmed]
  24. 1,25-(OH)2-vitamin D3 and calcipotriol induce IL-10 receptor gene expression in human epidermal cells. Michel, G., Gailis, A., Jarzebska-Deussen, B., Müschen, A., Mirmohammadsadegh, A., Ruzicka, T. Inflamm. Res. (1997) [Pubmed]
  25. Autocrine and exocrine regulation of interleukin-10 production in THP-1 cells stimulated with Borrelia burgdorferi lipoproteins. Giambartolomei, G.H., Dennis, V.A., Lasater, B.L., Murthy, P.K., Philipp, M.T. Infect. Immun. (2002) [Pubmed]
  26. Expression patterns of IL-10 ligand and receptor gene families provide leads for biological characterization. Nagalakshmi, M.L., Murphy, E., McClanahan, T., de Waal Malefyt, R. Int. Immunopharmacol. (2004) [Pubmed]
  27. Characterization of interleukin-10 receptor expression on B-cell chronic lymphocytic leukemia cells. Jurlander, J., Lai, C.F., Tan, J., Chou, C.C., Geisler, C.H., Schriber, J., Blumenson, L.E., Narula, S.K., Baumann, H., Caligiuri, M.A. Blood (1997) [Pubmed]
  28. Intracellular cytokine production and cytokine receptor interaction of cord mononuclear cells: relevance to cord blood transplantation. Han, P., Hodge, G. Br. J. Haematol. (1999) [Pubmed]
  29. Regulatory activity of autocrine IL-10 on dendritic cell functions. Corinti, S., Albanesi, C., la Sala, A., Pastore, S., Girolomoni, G. J. Immunol. (2001) [Pubmed]
  30. Contribution of the Box 1 and Box 2 motifs of cytokine receptors to Jak1 association and activation. Usacheva, A., Sandoval, R., Domanski, P., Kotenko, S.V., Nelms, K., Goldsmith, M.A., Colamonici, O.R. J. Biol. Chem. (2002) [Pubmed]
  31. A genome wide scan for association with multiple sclerosis in a N. Irish case control population. Heggarty, S., Sawcer, S., Hawkins, S., McDonnell, G., Droogan, A., Vandenbroeck, K., Hutchinson, M., Setakis, E., Compston, A., Graham, C. J. Neuroimmunol. (2003) [Pubmed]
  32. Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10). Gallagher, G., Dickensheets, H., Eskdale, J., Izotova, L.S., Mirochnitchenko, O.V., Peat, J.D., Vazquez, N., Pestka, S., Donnelly, R.P., Kotenko, S.V. Genes Immun. (2000) [Pubmed]
  33. Expression and regulation of interleukin-10 and interleukin-10 receptor in rat astroglial and microglial cells. Ledeboer, A., Brevé, J.J., Wierinckx, A., van der Jagt, S., Bristow, A.F., Leysen, J.E., Tilders, F.J., Van Dam, A.M. Eur. J. Neurosci. (2002) [Pubmed]
  34. Keratinocyte unresponsiveness towards interleukin-10: lack of specific binding due to deficient IL-10 receptor 1 expression. Seifert, M., Gruenberg, B.H., Sabat, R., Donner, P., Gruetz, G., Volk, H.D., Wolk, K., Asadullah, K. Exp. Dermatol. (2003) [Pubmed]
  35. Interleukin-10 expression is correlated with growth fraction in human non-small cell lung cancer xenografts. Naruke, M., Abe, Y., Hatanaka, H., Ohnishi, Y., Yamazaki, H., Kijima, H., Nakamura, M., Ueyama, Y., Kobayashi, K. Int. J. Oncol. (2001) [Pubmed]
  36. Differential IL-10R1 expression plays a critical role in IL-10-mediated immune regulation. Ding, Y., Qin, L., Zamarin, D., Kotenko, S.V., Pestka, S., Moore, K.W., Bromberg, J.S. J. Immunol. (2001) [Pubmed]
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