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Chemical Compound Review

NSC-112907     1-[(2R,3R,4S,5R)-3,4- dihydroxy-5...

Synonyms: SureCN587704, CHEMBL2311128, LS-7719, NSC112907, NSC-112907-D, ...
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Disease relevance of TETRAHYDROURIDINE


High impact information on TETRAHYDROURIDINE


Chemical compound and disease context of TETRAHYDROURIDINE


Biological context of TETRAHYDROURIDINE


Anatomical context of TETRAHYDROURIDINE


Associations of TETRAHYDROURIDINE with other chemical compounds




Analytical, diagnostic and therapeutic context of TETRAHYDROURIDINE


  1. Use of 5-trifluoromethyldeoxycytidine and tetrahydrouridine to circumvent catabolism and exploit high levels of cytidine deaminase in tumors to achieve DNA- and target-directed therapies. Mekras, J.A., Boothman, D.A., Greer, S.B. Cancer Res. (1985) [Pubmed]
  2. Inhibition of Escherichia coli cytidine deaminase by a phosphapyrimidine nucleoside. Ashley, G.W., Bartlett, P.A. J. Biol. Chem. (1984) [Pubmed]
  3. Capacity of deoxycytidine to selectively antagonize cytotoxicity of 5-halogenated analogs of deoxycytidine without loss of antiherpetic activity. Fox, L.M., Mekras, J.A., Bagwell, C.B., Greer, S.B. Antimicrob. Agents Chemother. (1982) [Pubmed]
  4. Selective radiosensitization and cytotoxicity of human melanoma cells using halogenated deoxycytidines and tetrahydrouridine. Lawrence, T.S., Davis, M.A. Int. J. Radiat. Oncol. Biol. Phys. (1989) [Pubmed]
  5. Pharmacology of combination chemotherapy of cytosine arabinoside (ara-C) and uracil arabinoside (ara-U) or tetrahydrouridine (THU) against murine leukemia L1210/0 in tumor-bearing mice. Avramis, V.I., Powell, W. Cancer Invest. (1987) [Pubmed]
  6. Metabolism and mechanism of action of 5-fluorodeoxycytidine. Newman, E.M., Santi, D.V. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  7. Deoxycytidine stimulates the in vitro growth of normal CFU-GM and reverses the negative regulatory effects of acidic isoferritin and prostaglandin E1. Bhalla, K., Cole, J., MacLaughlin, W., Baker, M., Arlin, Z., Graham, G., Grant, S. Blood (1986) [Pubmed]
  8. 5-Azacytidine increases HbF production and reduces anemia in sickle cell disease: dose-response analysis of subcutaneous and oral dosage regimens. Dover, G.J., Charache, S., Boyer, S.H., Vogelsang, G., Moyer, M. Blood (1985) [Pubmed]
  9. Preclinical pharmacology of arabinosyl-5-azacytidine in nonhuman primates. Heideman, R.L., Balis, F.M., McCully, C., Poplack, D.G. Cancer Res. (1988) [Pubmed]
  10. Potentiation of halogenated pyrimidine radiosensitizers in human carcinoma cells by beta-lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran- 5,6-dione), a novel DNA repair inhibitor. Boothman, D.A., Greer, S., Pardee, A.B. Cancer Res. (1987) [Pubmed]
  11. Pharmacokinetic considerations in evaluating the effects of tetrahydrouridine on 5-azacytidine chemotherapy in L1210 leukemic mice. Kelly, C.J., Gaudio, L., Yesair, D.W., Schoenemann, P.T., Wodinsky, I. Cancer treatment reports. (1978) [Pubmed]
  12. Influence of tetrahydrouridine on the pharmacokinetics of intrathecally administered 1-beta-D-arabinofuranosylcytosine. Riccardi, R., Chabner, B., Glaubiger, D.L., Wood, J., Poplack, D.G. Cancer Res. (1982) [Pubmed]
  13. Evaluation of carbodine, the carbocyclic analog of cytidine, and related carbocyclic analogs of pyrimidine nucleosides for antiviral activity against human influenza Type A viruses. Shannon, W.M., Arnett, G., Westbrook, L., Shealy, Y.F., O'Dell, C.A., Brockman, R.W. Antimicrob. Agents Chemother. (1981) [Pubmed]
  14. The action of bacterial cytidine deaminase on 5,6-dihydrocytidine. Evans, B.E., Mitchell, G.N., Wolfenden, R. Biochemistry (1975) [Pubmed]
  15. Influence of tetrahydrouridine on the phosphorylation of 1-beta-D-arabinofuranosyl-cytosine (ara-C) by enzymes from solid tumors in vitro. Furner, R.L., Mellett, L.B., Herren, T.C. J. Pharmacol. Exp. Ther. (1975) [Pubmed]
  16. Epimer interconversion, isomerization, and hydrolysis of tetrahydrouridine: implications for cytidine deaminase inhibition. Xiang, T.X., Niemi, R., Bummer, P., Anderson, B.D. Journal of pharmaceutical sciences. (2003) [Pubmed]
  17. Sensitization to X ray by 5-chloro-2'-deoxycytidine co-administered with tetrahydrouridine in several mammalian cell lines and studies of 2'-chloro derivatives. Perez, L.M., Greer, S. Int. J. Radiat. Oncol. Biol. Phys. (1986) [Pubmed]
  18. Drug resistance to 5-aza-2'-deoxycytidine, 2',2'-difluorodeoxycytidine, and cytosine arabinoside conferred by retroviral-mediated transfer of human cytidine deaminase cDNA into murine cells. Eliopoulos, N., Cournoyer, D., Momparler, R.L. Cancer Chemother. Pharmacol. (1998) [Pubmed]
  19. Antiherpes virus activity and effect on deoxyribonucleoside triphosphate pools of (E)-5-(2-bromovinyl)-2'-deoxycytidine in combination with deaminase inhibitors. Aduma, P.J., Gupta, S.V., De Clercq, E. Antiviral Res. (1990) [Pubmed]
  20. Use of 5-fluorodeoxycytidine and tetrahydrouridine to exploit high levels of deoxycytidylate deaminase in tumors to achieve DNA- and target-directed therapies. Mekras, J.A., Boothman, D.A., Perez, L.M., Greer, S. Cancer Res. (1984) [Pubmed]
  21. Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues. Driscoll, J.S., Marquez, V.E., Plowman, J., Liu, P.S., Kelley, J.A., Barchi, J.J. J. Med. Chem. (1991) [Pubmed]
  22. Marked radiosensitization of cells in culture to X ray by 5-chlorodeoxycytidine coadministered with tetrahydrouridine, and inhibitors of pyrimidine biosynthesis. Perez, L.M., Mekras, J.A., Briggle, T.V., Greer, S. Int. J. Radiat. Oncol. Biol. Phys. (1984) [Pubmed]
  23. Forced expression of cytidine deaminase confers resistance to cytosine arabinoside and gemcitabine. Neff, T., Blau, C.A. Exp. Hematol. (1996) [Pubmed]
  24. Protective, tumor-selective dual pathway activation of 5-fluoro-2'-deoxycytidine provided by tetrahydrouridine in mice bearing mammary adenocarcinoma-755. Boothman, D.A., Briggle, T.V., Greer, S. Cancer Res. (1987) [Pubmed]
  25. Human immunodeficiency virus type 1 induces 1-beta-D-arabinofuranosylcytosine resistance in human H9 cell line. Yusa, K., Oh-hara, T., Tsukahara, S., Tsuruo, T. J. Biol. Chem. (1992) [Pubmed]
  26. The effect of deoxycytidine and tetrahydrouridine in purine nucleoside phosphorylase deficiency. Stoop, J.W., Zegers, B.J., Spaapen, L.J., Kuis, W., Roord, J.J., Rijkers, G.T., Staal, G.E., Rijksen, G., Duran, M., Wadman, S.K. Adv. Exp. Med. Biol. (1984) [Pubmed]
  27. Analytical and pharmacokinetic studies with 5-chloro-2'-deoxycytidine. Hale, J.T., Bigelow, J.C., Mathews, L.A., McCormack, J.J. Biochem. Pharmacol. (2002) [Pubmed]
  28. The identification of 5,6-dihydrouridine in normal human urine by combined gas chromatography/mass spectrometry. Reimer, M.L., Schram, K.H., Nakano, K., Yasaka, T. Anal. Biochem. (1989) [Pubmed]
  29. Microbiologic assay for cytosine arabinoside (NSC-63878): the use of a mutant of streptococcus faecium var. durans resistant to methotrexate (NSC-740) and 6-mercaptopurine (NSC-755). Mehta, B.M., Meyers, M.B., Hutchison, D.J. Cancer chemotherapy reports. Part 1. (1975) [Pubmed]
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