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Chemical Compound Review

NSC-112907     1-[(2R,3R,4S,5R)-3,4- dihydroxy-5...

Synonyms: SureCN587704, CHEMBL2311128, LS-7719, NSC112907, NSC-112907-D, ...
 
 
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Disease relevance of TETRAHYDROURIDINE

 

High impact information on TETRAHYDROURIDINE

 

Chemical compound and disease context of TETRAHYDROURIDINE

 

Biological context of TETRAHYDROURIDINE

 

Anatomical context of TETRAHYDROURIDINE

 

Associations of TETRAHYDROURIDINE with other chemical compounds

 

Gene context of TETRAHYDROURIDINE

 

Analytical, diagnostic and therapeutic context of TETRAHYDROURIDINE

References

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  5. Pharmacology of combination chemotherapy of cytosine arabinoside (ara-C) and uracil arabinoside (ara-U) or tetrahydrouridine (THU) against murine leukemia L1210/0 in tumor-bearing mice. Avramis, V.I., Powell, W. Cancer Invest. (1987) [Pubmed]
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  7. Deoxycytidine stimulates the in vitro growth of normal CFU-GM and reverses the negative regulatory effects of acidic isoferritin and prostaglandin E1. Bhalla, K., Cole, J., MacLaughlin, W., Baker, M., Arlin, Z., Graham, G., Grant, S. Blood (1986) [Pubmed]
  8. 5-Azacytidine increases HbF production and reduces anemia in sickle cell disease: dose-response analysis of subcutaneous and oral dosage regimens. Dover, G.J., Charache, S., Boyer, S.H., Vogelsang, G., Moyer, M. Blood (1985) [Pubmed]
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  11. Pharmacokinetic considerations in evaluating the effects of tetrahydrouridine on 5-azacytidine chemotherapy in L1210 leukemic mice. Kelly, C.J., Gaudio, L., Yesair, D.W., Schoenemann, P.T., Wodinsky, I. Cancer treatment reports. (1978) [Pubmed]
  12. Influence of tetrahydrouridine on the pharmacokinetics of intrathecally administered 1-beta-D-arabinofuranosylcytosine. Riccardi, R., Chabner, B., Glaubiger, D.L., Wood, J., Poplack, D.G. Cancer Res. (1982) [Pubmed]
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  15. Influence of tetrahydrouridine on the phosphorylation of 1-beta-D-arabinofuranosyl-cytosine (ara-C) by enzymes from solid tumors in vitro. Furner, R.L., Mellett, L.B., Herren, T.C. J. Pharmacol. Exp. Ther. (1975) [Pubmed]
  16. Epimer interconversion, isomerization, and hydrolysis of tetrahydrouridine: implications for cytidine deaminase inhibition. Xiang, T.X., Niemi, R., Bummer, P., Anderson, B.D. Journal of pharmaceutical sciences. (2003) [Pubmed]
  17. Sensitization to X ray by 5-chloro-2'-deoxycytidine co-administered with tetrahydrouridine in several mammalian cell lines and studies of 2'-chloro derivatives. Perez, L.M., Greer, S. Int. J. Radiat. Oncol. Biol. Phys. (1986) [Pubmed]
  18. Drug resistance to 5-aza-2'-deoxycytidine, 2',2'-difluorodeoxycytidine, and cytosine arabinoside conferred by retroviral-mediated transfer of human cytidine deaminase cDNA into murine cells. Eliopoulos, N., Cournoyer, D., Momparler, R.L. Cancer Chemother. Pharmacol. (1998) [Pubmed]
  19. Antiherpes virus activity and effect on deoxyribonucleoside triphosphate pools of (E)-5-(2-bromovinyl)-2'-deoxycytidine in combination with deaminase inhibitors. Aduma, P.J., Gupta, S.V., De Clercq, E. Antiviral Res. (1990) [Pubmed]
  20. Use of 5-fluorodeoxycytidine and tetrahydrouridine to exploit high levels of deoxycytidylate deaminase in tumors to achieve DNA- and target-directed therapies. Mekras, J.A., Boothman, D.A., Perez, L.M., Greer, S. Cancer Res. (1984) [Pubmed]
  21. Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues. Driscoll, J.S., Marquez, V.E., Plowman, J., Liu, P.S., Kelley, J.A., Barchi, J.J. J. Med. Chem. (1991) [Pubmed]
  22. Marked radiosensitization of cells in culture to X ray by 5-chlorodeoxycytidine coadministered with tetrahydrouridine, and inhibitors of pyrimidine biosynthesis. Perez, L.M., Mekras, J.A., Briggle, T.V., Greer, S. Int. J. Radiat. Oncol. Biol. Phys. (1984) [Pubmed]
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  25. Human immunodeficiency virus type 1 induces 1-beta-D-arabinofuranosylcytosine resistance in human H9 cell line. Yusa, K., Oh-hara, T., Tsukahara, S., Tsuruo, T. J. Biol. Chem. (1992) [Pubmed]
  26. The effect of deoxycytidine and tetrahydrouridine in purine nucleoside phosphorylase deficiency. Stoop, J.W., Zegers, B.J., Spaapen, L.J., Kuis, W., Roord, J.J., Rijkers, G.T., Staal, G.E., Rijksen, G., Duran, M., Wadman, S.K. Adv. Exp. Med. Biol. (1984) [Pubmed]
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  28. The identification of 5,6-dihydrouridine in normal human urine by combined gas chromatography/mass spectrometry. Reimer, M.L., Schram, K.H., Nakano, K., Yasaka, T. Anal. Biochem. (1989) [Pubmed]
  29. Microbiologic assay for cytosine arabinoside (NSC-63878): the use of a mutant of streptococcus faecium var. durans resistant to methotrexate (NSC-740) and 6-mercaptopurine (NSC-755). Mehta, B.M., Meyers, M.B., Hutchison, D.J. Cancer chemotherapy reports. Part 1. (1975) [Pubmed]
 
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