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Gene Review

ORF31  -  type 1 membrane protein; contains a signal...

Cercopithecine herpesvirus 9

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Disease relevance of ORF31


High impact information on ORF31

  • The nucleotide sequence alignments revealed a highly conserved gB gene, with homologies ranging between 87.2 and 99.6%, and a more variable gD gene, with homologies ranging between 71.3 and 98.9% [3].
  • The glycoprotein B (gB) and D (gD) genes from five ruminant alphaherpesviruses, bovine herpesvirus 1 (BHV-1), bovine herpesvirus 5 (BHV-5), caprine herpesvirus 1 (CapHV-1), cervine herpesvirus 1, and rangiferine herpesvirus 1, were partially sequenced [3].
  • The phylogenetic analysis of the gB and gD nucleotide and deduced amino acid sequences revealed that BHV-5 is the most closely related virus to the BHV-1 subtype 1 and BHV-1 subtype 2 cluster and that CapHV-1 is the most distantly related virus [3].
  • Sequence analysis revealed a gB-specific open-reading frame comprising 881 amino acids [4].
  • Applying the more sensitive liquid RT-PCR, however, an acute infection was demonstrated in one of the trigeminal ganglia by amplification of viral transcripts coding for glycoprotein B. The failure to detect these transcripts in the other trigeminal ganglia and the lung indicates a latent infection [5].

Chemical compound and disease context of ORF31

  • Features shared with bovine herpesvirus 1 (BHV-1) gB include two broad hydrophobic regions, six N-glycosylation sites and ten conserved cysteine residues in the gB extracellular domain [6].

Biological context of ORF31

  • Primer extension experiments identified transcript start sites for the SVV and VZV gB genes and permitted a comparison of the sequences upstream of the SVV and VZV gB ORFs [1].
  • The deduced SVV and VZV gB polypeptides share 78.9% amino acid identity and predicted N-linked glycosylation sites, cleavage sites and transmembrane regions [1].
  • Conformation-dependent epitopes were shown to contribute largely to the overall antibody response to gB in naturally infected swine and immunized mice [7].

Analytical, diagnostic and therapeutic context of ORF31

  • Genetic characterization was facilitated by PCR analysis using primers based on conserved regions of the glycoprotein B and D (gB and gD) genes of the antigenically closely related canid (CHV) and felid (FHV) herpesvirus [8].
  • On the basis of sequence data for the gB gene, a nested PCR combined with restriction enzyme analysis (REA) of the PCR products was developed for the simultaneous detection and identification of the viruses that were studied [3].
  • These proteins, which may represent subunits of gB rather than the entire molecule, appear the most immunodominant of the structural virion proteins as identified by Western blot [9].
  • Glycoprotein B of Aujeszky's disease virus: topographical epitope mapping and epitope-specific antibody response [7].


  1. DNA sequence and transcriptional analysis of the simian varicella virus glycoprotein B gene. Pumphrey, C.Y., Gray, W.L. J. Gen. Virol. (1994) [Pubmed]
  2. Identification of the human cytomegalovirus glycoprotein B gene and induction of neutralizing antibodies via its expression in recombinant vaccinia virus. Cranage, M.P., Kouzarides, T., Bankier, A.T., Satchwell, S., Weston, K., Tomlinson, P., Barrell, B., Hart, H., Bell, S.E., Minson, A.C. EMBO J. (1986) [Pubmed]
  3. Studies of genetic relationships between bovine, caprine, cervine, and rangiferine alphaherpesviruses and improved molecular methods for virus detection and identification. Ros, C., Belák, S. J. Clin. Microbiol. (1999) [Pubmed]
  4. Molecular characterization and baculovirus expression of the glycoprotein B of a seal herpesvirus (phocid herpesvirus-1). Harder, T.C., Osterhaus, A.D. Virology (1997) [Pubmed]
  5. Equine herpesvirus 4 DNA in trigeminal ganglia of naturally infected horses detected by direct in situ PCR. Borchers, K., Wolfinger, U., Lawrenz, B., Schellenbach, A., Ludwig, H. J. Gen. Virol. (1997) [Pubmed]
  6. Characterization of the glycoprotein B gene from ruminant alphaherpesviruses. Ros, C., Belák, S. Virus Genes (2002) [Pubmed]
  7. Glycoprotein B of Aujeszky's disease virus: topographical epitope mapping and epitope-specific antibody response. Zaripov, M.M., Morenkov, O.S., Siklodi, B., Barna-Vetro, I., Gyöngyösi-Horvath, A., Fodor, I. Res. Virol. (1998) [Pubmed]
  8. Characterization of phocid herpesvirus-1 and -2 as putative alpha- and gammaherpesviruses of North American and European pinnipeds. Harder, T.C., Harder, M., Vos, H., Kulonen, K., Kennedy-Stoskopf, S., Liess, B., Appel, M.J., Osterhaus, A.D. J. Gen. Virol. (1996) [Pubmed]
  9. Comparative studies of the structural proteins and glycoproteins of equine herpesviruses 2 and 5. Agius, C.T., Crabb, B.S., Telford, E.A., Davison, A.J., Studdert, M.J. J. Gen. Virol. (1994) [Pubmed]
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