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Gene Review

ftsQ  -  divisome assembly protein, membrane...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0094, JW0091
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Disease relevance of ftsQ

  • A 1.2-kilobase-pair BamHI fragment from a cell envelope-cell division gene cluster of Escherichia coli containing ddl and part of ftsQ was cloned and sequenced, and the sequence was interpreted with the aid of genetic complementation and promoter fusion data for the region [1].
  • We have used the easily synchronizable bacterium Caulobacter crescentus to determine when the cell division genes ftsQ and ftsA are transcribed during the DNA replication cycle and to compare their transcription with that of ftsZ [2].
  • The three ORFs (YFIH, ORF5 and ORF6) located downstream of the cell division genes ftsQ and ftsZ in Brevibacterium lactofermentum were disrupted by single homologous recombination events between internal fragments of the corresponding genes and the chromosomal sequences [3].

High impact information on ftsQ

  • The ftsQA genes, which encode functions required for cell division in E. coli, are regulated by promoters P1 and P2, located upstream of the ftsQ gene [4].
  • The promoter, ftsA1p, located in the ftsQ coding sequence, co-regulates ftsA and ftsZ [5].
  • Cells which are lysogenic for lambda JFL100 transcribe the cloned lacZ from promoter(s) within the ftsQ and ftsA sequences [6].
  • Here we also describe a novel screen for cell division mutants based on a wrinkled-colony morphology, which yielded several new point mutations in ftsQ [7].
  • In ftsA, ftsI, and ftsQ mutants, which form filaments with an indented morphology, Z rings formed but their contraction was blocked [8].

Biological context of ftsQ

  • Whereas the latter strains showed a slow recovery of cell division after a shift back to the permissive temperature, ftsZ and ftsQ filaments recovered quickly [9].
  • Analysis of the DNA sequence further showed that the termination codon of ddl is separated from the initiation codon of ftsQ by one base, which suggests that these two genes may be translationally coupled when transcription is initiated upstream of ddl [1].
  • The analysis revealed defective ftsQ and mraY genes, truncated by a nonsense and a frame-shift mutation, respectively [10].
  • The essential cell division genes ftsQ, ftsA and ftsZ map in a cluster of cell envelope genes located at two minutes on the Escherichia coli genetic map and appear to constitute an atypical operon [11].
  • Amplification of a 2.6-kilobase chromosomal fragment of the mra region of Escherichia coli encompassing the ftsI(pbpB) gene and an open reading frame upstream with lethal to E. coli strains with mutations of the flanking cell division genes ftsQ, ftsA, and ftsZ [12].

Anatomical context of ftsQ

  • 2) The ftsQ and ftsl gene products are integral proteins of the cytoplasmic membrane with small cytoplasmic domains and large periplasmic domains [13].

Associations of ftsQ with chemical compounds


Physical interactions of ftsQ

  • The observation that the termination codon of ftsQ overlaps with a potential initiation codon for ftsA suggested that these two genes may be translationally coupled when transcription is initiated upstream of the ftsQ coding sequence [15].

Regulatory relationships of ftsQ

  • We have previously shown that ftsA can be expressed from a weak promoter located within the ftsQ gene (Robinson et al., J. Bacteriol. 160:546-555, 1984) [16].

Other interactions of ftsQ

  • Already at the premissive temperature, all mutants, particularly the pbpB and ftsQ mutants, showed an increased average cell length and cell mass [9].

Analytical, diagnostic and therapeutic context of ftsQ


  1. Further evidence for overlapping transcriptional units in an Escherichia coli cell envelope-cell division gene cluster: DNA sequence and transcriptional organization of the ddl ftsQ region. Robinson, A.C., Kenan, D.J., Sweeney, J., Donachie, W.D. J. Bacteriol. (1986) [Pubmed]
  2. Ordered expression of ftsQA and ftsZ during the Caulobacter crescentus cell cycle. Sackett, M.J., Kelly, A.J., Brun, Y.V. Mol. Microbiol. (1998) [Pubmed]
  3. The cell division genes ftsQ and ftsZ, but not the three downstream open reading frames YFIH, ORF5 and ORF6, are essential for growth and viability in Brevibacterium lactofermentum ATCC 13869. Honrubia, M.P., Ramos, A., Gil, J.A. Mol. Genet. Genomics (2001) [Pubmed]
  4. Control of cell division in Escherichia coli: regulation of transcription of ftsQA involves both rpoS and SdiA-mediated autoinduction. Sitnikov, D.M., Schineller, J.B., Baldwin, T.O. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  5. Regulation of Escherichia coli cell division genes ftsA and ftsZ by the two-component system rcsC-rcsB. Carballès, F., Bertrand, C., Bouché, J.P., Cam, K. Mol. Microbiol. (1999) [Pubmed]
  6. Transcriptional regulation of cell division genes in Escherichia coli. Dewar, S.J., Kagan-Zur, V., Begg, K.J., Donachie, W.D. Mol. Microbiol. (1989) [Pubmed]
  7. Mutants, Suppressors, and Wrinkled Colonies: Mutant Alleles of the Cell Division Gene ftsQ Point to Functional Domains in FtsQ and a Role for Domain 1C of FtsA in Divisome Assembly. Goehring, N.W., Petrovska, I., Boyd, D., Beckwith, J. J. Bacteriol. (2007) [Pubmed]
  8. FtsZ ring formation in fts mutants. Addinall, S.G., Bi, E., Lutkenhaus, J. J. Bacteriol. (1996) [Pubmed]
  9. Division behavior and shape changes in isogenic ftsZ, ftsQ, ftsA, pbpB, and ftsE cell division mutants of Escherichia coli during temperature shift experiments. Taschner, P.E., Huls, P.G., Pas, E., Woldringh, C.L. J. Bacteriol. (1988) [Pubmed]
  10. The analysis of cell division and cell wall synthesis genes reveals mutationally inactivated ftsQ and mraY in a protoplast-type L-form of Escherichia coli. Siddiqui, R.A., Hoischen, C., Holst, O., Heinze, I., Schlott, B., Gumpert, J., Diekmann, S., Grosse, F., Platzer, M. FEMS Microbiol. Lett. (2006) [Pubmed]
  11. Structure and expression of the cell division genes ftsQ, ftsA and ftsZ. Yi, Q.M., Rockenbach, S., Ward, J.E., Lutkenhaus, J. J. Mol. Biol. (1985) [Pubmed]
  12. Inhibition of growth of ftsQ, ftsA, and ftsZ mutant cells of Escherichia coli by amplification of a chromosomal region encompassing closely aligned cell division and cell growth genes. Jung, H.K., Ishino, F., Matsuhashi, M. J. Bacteriol. (1989) [Pubmed]
  13. Alkaline phosphatase fusions in the study of cell division genes. Barondess, J.J., Carson, M., Guzman Verduzco, L.M., Beckwith, J. Res. Microbiol. (1991) [Pubmed]
  14. Overproduction and identification of the ftsQ gene product, an essential cell division protein in Escherichia coli K-12. Storts, D.R., Aparicio, O.M., Schoemaker, J.M., Markovitz, A. J. Bacteriol. (1989) [Pubmed]
  15. DNA sequence and transcriptional organization of essential cell division genes ftsQ and ftsA of Escherichia coli: evidence for overlapping transcriptional units. Robinson, A.C., Kenan, D.J., Hatfull, G.F., Sullivan, N.F., Spiegelberg, R., Donachie, W.D. J. Bacteriol. (1984) [Pubmed]
  16. Regulation of expression of the ftsA cell division gene by sequences in upstream genes. Dewar, S.J., Donachie, W.D. J. Bacteriol. (1990) [Pubmed]
  17. A murC gene from coryneform bacteria. Wachi, M., Wijayarathna, C.D., Teraoka, H., Nagai, K. Appl. Microbiol. Biotechnol. (1999) [Pubmed]
  18. Identification and semi-quantitative analysis of Mycobacterium tuberculosis H37Rv ftsZ gene-specific promoter activity-containing regions. Roy, S., Mir, M.A., Anand, S.P., Niederweis, M., Ajitkumar, P. Res. Microbiol. (2004) [Pubmed]
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