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Gene Review

fliO  -  flagellar biosynthesis protein

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1945, JW5316, flbD
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Disease relevance of fliO


High impact information on fliO

  • In this issue of Cell, describe the construction of an in silico model for the regulatory network responsible for the control of flagellar biosynthesis in E. coli based on quantitative gene expression data [5].
  • We report that flbD, one of the early genes required in trans for expression of these operons, codes for a 52-kDa protein homologous to the transcriptional activators NtrC (NRI), NifA, DctD, HydG, and XylR [6].
  • A 1.6-kb KpnI fragment from the PAK chromosome that contained the fliO gene was sequenced [1].
  • Several genes up-regulated by BaeR overproduction, including genes for maltose transport, chemotactic responses, and flagellar biosynthesis, required an intact PhoBR or CreBC two-component regulatory system for up-regulation [7].
  • Type III secretion functions in flagellar biosynthesis and in export of virulence factors from several animal pathogens, and for plant pathogens, it has been shown to be involved in the export of elicitors of the hypersensitive reaction [8].

Biological context of fliO

  • One of the unique genes identified, flbD, demonstrated homology to an ORF from the same operon of Tp [9].
  • Most of the identified proteins were shown to be involved in energy metabolism, several cellular molecule biosynthetic pathways and catabolism, cell processes, flagellar biosynthesis and motility, and protein translation and folding [10].


  1. Characterization of Pseudomonas aeruginosa fliO, a gene involved in flagellar biosynthesis and adherence. Simpson, D.A., Ramphal, R., Lory, S. Infect. Immun. (1995) [Pubmed]
  2. The anti-sigma factors. Hughes, K.T., Mathee, K. Annu. Rev. Microbiol. (1998) [Pubmed]
  3. Generation of a Tn5 promoter probe and its use in the study of gene expression in Caulobacter crescentus. Bellofatto, V., Shapiro, L., Hodgson, D.A. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  4. Bacterial flagellar diversity in the post-genomic era. Pallen, M.J., Penn, C.W., Chaudhuri, R.R. Trends Microbiol. (2005) [Pubmed]
  5. Flagellar biosynthesis in silico: building quantitative models of regulatory networks. Herrgård, M.J., Palsson, B.Ø. Cell (2004) [Pubmed]
  6. FlbD of Caulobacter crescentus is a homologue of the NtrC (NRI) protein and activates sigma 54-dependent flagellar gene promoters. Ramakrishnan, G., Newton, A. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  7. Genome-wide analyses of Escherichia coli gene expression responsive to the BaeSR two-component regulatory system. Nishino, K., Honda, T., Yamaguchi, A. J. Bacteriol. (2005) [Pubmed]
  8. Erwinia amylovora secretes harpin via a type III pathway and contains a homolog of yopN of Yersinia spp. Bogdanove, A.J., Wei, Z.M., Zhao, L., Beer, S.V. J. Bacteriol. (1996) [Pubmed]
  9. Identification of a large motility operon in Borrelia burgdorferi by semi-random PCR chromosome walking. Ge, Y., Charon, N.W. Gene (1997) [Pubmed]
  10. Proteome response of Escherichia coli fed-batch culture to temperature downshift. Kim, Y.H., Han, K.Y., Lee, K., Lee, J. Appl. Microbiol. Biotechnol. (2005) [Pubmed]
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