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Gene Review

wzc  -  colanic acid production tyrosine-protein...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2054, JW2045
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Disease relevance of wzc


High impact information on wzc

  • We have used the bacterially expressed SH2 domain of abl protein-tyrosine kinase to evaluate the ability of this domain to bind to cellular proteins. ablSH2 specifically bound to a number of tyrosine-phosphorylated proteins from cells transformed by tyrosine kinase oncogenes in a filter-binding assay and to a subset of those proteins in solution [6].
  • Mutants of Abelson virus encoding temperature-sensitive protein-tyrosine kinase (EC were created by site-directed mutagenesis using sequence information from temperature-sensitive mutants of the related v-src oncogene [7].
  • Genetic and biochemical data indicate that the SH2 domain of the p60v-src (v-Src) protein-tyrosine kinase is required for full v-src transforming activity and may direct the association of v-Src with specific tyrosine-phosphorylated proteins [8].
  • Here, we have determined the membrane topology of Wzc by performing translational fusions of lacZ and phoA reporter genes to the wzc gene [9].
  • Lck is a lymphoid-specific, Src family protein-tyrosine kinase that is known to interact with the T-cell coreceptors, CD4 and CD8 [10].

Chemical compound and disease context of wzc


Biological context of wzc

  • The resistance of a double knock-out wzc-etk-mutant was also analyzed and complementation experiments were performed by checking the effect of plasmid vectors expressing either Wzc or Etk [1].
  • Three additional genes, wza, wzb and wzc, encode homologues to proteins that are encoded by gene clusters involved in expression of a variety of bacterial exopolysaccharides [12].
  • We have shown that CpsD is also an autophosphorylating protein-tyrosine kinase and that point mutations in cpsD affecting either the ATP-binding domain (Walker A motif) or the carboxy-terminal [YGX]4 repeat domain eliminated tyrosine phosphorylation of CpsD [13].
  • Temperature-sensitive protein-tyrosine kinase (EC mutants of the oncogene v-abl have been obtained by a direct screening of kinase mutants in bacteria [14].
  • The protein tyrosine kinase (PTK) Lck phosphorylates the zeta-chain, which in turn associates with another PTK, ZAP70, and stimulates its phosphorylation activity [15].

Anatomical context of wzc

  • The results of the present study suggest that A. actinomycetemcomitans LPS, via the activation of protein tyrosine kinase and protein kinase C and the regulatory control of cytokines, stimulates NO production by murine macrophages [16].
  • The results suggest that ambroxol exerts a depressant effect on LPS- or fMLP-stimulated free radical production and granule enzyme release by rat alveolar macrophages, which may be attributed to its inhibitory action on the activation process, protein kinase C, but its action on protein tyrosine kinase is not suggested [17].

Associations of wzc with chemical compounds


Other interactions of wzc


  1. A novel role for protein-tyrosine kinase Etk from Escherichia coli K-12 related to polymyxin resistance. Lacour, S., Doublet, P., Obadia, B., Cozzone, A.J., Grangeasse, C. Res. Microbiol. (2006) [Pubmed]
  2. Involvement of a protein tyrosine kinase in production of the polymeric bioemulsifier emulsan from the oil-degrading strain Acinetobacter lwoffii RAG-1. Nakar, D., Gutnick, D.L. J. Bacteriol. (2003) [Pubmed]
  3. Isolation and characterization of a protein-tyrosine kinase and a phosphotyrosine-protein phosphatase from Klebsiella pneumoniae. Preneta, R., Jarraud, S., Vincent, C., Doublet, P., Duclos, B., Etienne, J., Cozzone, A.J. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2002) [Pubmed]
  4. Purification and characterization of a protein-tyrosine kinase encoded by the Abelson murine leukemia virus. Foulkes, J.G., Chow, M., Gorka, C., Frackelton, A.R., Baltimore, D. J. Biol. Chem. (1985) [Pubmed]
  5. Staphylococcus aureus operates protein-tyrosine phosphorylation through a specific mechanism. Soulat, D., Jault, J.M., Duclos, B., Geourjon, C., Cozzone, A.J., Grangeasse, C. J. Biol. Chem. (2006) [Pubmed]
  6. The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity. Mayer, B.J., Jackson, P.K., Baltimore, D. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  7. Isolation of temperature-sensitive Abelson virus mutants by site-directed mutagenesis. Engelman, A., Rosenberg, N. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  8. Multiple SH2-mediated interactions in v-src-transformed cells. Koch, C.A., Moran, M.F., Anderson, D., Liu, X.Q., Mbamalu, G., Pawson, T. Mol. Cell. Biol. (1992) [Pubmed]
  9. Structural organization of the protein-tyrosine autokinase Wzc within Escherichia coli cells. Doublet, P., Grangeasse, C., Obadia, B., Vaganay, E., Cozzone, A.J. J. Biol. Chem. (2002) [Pubmed]
  10. A Zn2+ ion links the cytoplasmic tail of CD4 and the N-terminal region of Lck. Huse, M., Eck, M.J., Harrison, S.C. J. Biol. Chem. (1998) [Pubmed]
  11. Mechanisms associated with Acanthamoeba castellanii (T4) phagocytosis. Alsam, S., Sissons, J., Dudley, R., Khan, N.A. Parasitol. Res. (2005) [Pubmed]
  12. Gene products required for surface expression of the capsular form of the group 1 K antigen in Escherichia coli (O9a:K30). Drummelsmith, J., Whitfield, C. Mol. Microbiol. (1999) [Pubmed]
  13. Tyrosine phosphorylation of CpsD negatively regulates capsular polysaccharide biosynthesis in streptococcus pneumoniae. Morona, J.K., Paton, J.C., Miller, D.C., Morona, R. Mol. Microbiol. (2000) [Pubmed]
  14. Isolation of temperature-sensitive tyrosine kinase mutants of v-abl oncogene by screening with antibodies for phosphotyrosine. Kipreos, E.T., Lee, G.J., Wang, J.Y. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  15. Phosphorylated T cell receptor zeta-chain and ZAP70 tandem SH2 domains form a 1:3 complex in vitro. Weissenhorn, W., Eck, M.J., Harrison, S.C., Wiley, D.C. Eur. J. Biochem. (1996) [Pubmed]
  16. Nitric oxide production by a murine macrophage cell line (RAW264.7) stimulated with lipopolysaccharide from Actinobacillus actinomycetemcomitans. Sosroseno, W., Barid, I., Herminajeng, E., Susilowati, H. Oral Microbiol. Immunol. (2002) [Pubmed]
  17. Depressant effects of ambroxol on lipopolysaccharide- or fMLP-stimulated free radical production and granule enzyme release by alveolar macrophages. Lee, C.S., Jang, Y.Y., Han, E.S. Pulmonary pharmacology & therapeutics. (1999) [Pubmed]
  18. Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: a possible role for protein tyrosine kinase. Ruetten, H., Thiemermann, C. Br. J. Pharmacol. (1997) [Pubmed]
  19. Cells of Escherichia coli contain a protein-tyrosine kinase, Wzc, and a phosphotyrosine-protein phosphatase, Wzb. Vincent, C., Doublet, P., Grangeasse, C., Vaganay, E., Cozzone, A.J., Duclos, B. J. Bacteriol. (1999) [Pubmed]
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