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Chemical Compound Review

ambroxol     4-[(2-amino-3,5-dibromo...

Synonyms: Amboxol, Ambroxolum, Ambroxol Base, Ambroxol (INN), SureCN18702, ...
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Disease relevance of ambroxol


High impact information on ambroxol


Chemical compound and disease context of ambroxol


Biological context of ambroxol

  • The inhibitory effect of ambroxol on silica-induced cell death appears to provide the protective effect on pulmonary tissues against the toxic action of silica [14].
  • Ambroxol decreased the silica-induced cell viability loss in macrophages [14].
  • Imipramine and ambroxol shift the temperature activity profile towards lower temperatures without a substantial influence on the shape of the profile and on the maximal rate of hydrolysis [15].
  • Ambroxol-induced modification of ion transport in human airway Calu-3 epithelia [16].
  • CONCLUSIONS: In this population of healthy mate volunteers, results showed the bioavailability of loratadine and ambroxol from the new formulation and did not show impairment of absorption when the drugs were formulated in a combination tablet [17].

Anatomical context of ambroxol


Associations of ambroxol with other chemical compounds


Gene context of ambroxol

  • 3. Of the recombinant CYP examined, only CYP3A4 metabolized ambroxol to DBAA [25].
  • In isolated type II pneumocytes of ambroxol-treated animals, SP-C protein and mRNA content were increased, whereas SP-A, -B and -D protein, mRNA, and immunoreactivity remained unaffected [26].
  • Compared to the control group, TNF-alpha, IL-6 and TGF-beta1 levels in the BAL in both ambroxol- and dexamethasone-treated groups were significantly reduced at 24 and 48 h [22].
  • OBJECTIVE: The aim of this study is to investigate whether ambroxol inhibits inflammatory responses in a murine model of lipopolysaccharide-induced acute lung injury (ALI) [22].
  • The data suggest that surfactant protein expression is modulated in a cell-specific manner by ambroxol, as type II pneumocytes exhibited an increase in SP-C, whereas Clara cells exhibited an increase in the immunoreactivity for SP-B accounting for the increased SP-B content of whole lung tissue [26].

Analytical, diagnostic and therapeutic context of ambroxol


  1. Inhibition of tetrodotoxin (TTX)-resistant and TTX-sensitive neuronal Na(+) channels by the secretolytic ambroxol. Weiser, T., Wilson, N. Mol. Pharmacol. (2002) [Pubmed]
  2. Ambroxol, a Nav1.8-preferring Na(+) channel blocker, effectively suppresses pain symptoms in animal models of chronic, neuropathic and inflammatory pain. Gaida, W., Klinder, K., Arndt, K., Weiser, T. Neuropharmacology (2005) [Pubmed]
  3. A controlled trial of ambroxol in chronic bronchitis. Guyatt, G.H., Townsend, M., Kazim, F., Newhouse, M.T. Chest (1987) [Pubmed]
  4. Therapeutic activity of ambroxol theophyllinacetate in chronic obstructive pulmonary diseases. Primbs, K. Clinical therapeutics. (1985) [Pubmed]
  5. Ambroxol suppresses influenza-virus proliferation in the mouse airway by increasing antiviral factor levels. Yang, B., Yao, D.F., Ohuchi, M., Ide, M., Yano, M., Okumura, Y., Kido, H. Eur. Respir. J. (2002) [Pubmed]
  6. Response to surfactant activator (ambroxol) in alveolar proteinosis. Diaz, J.P., Manresa Presas, F., Benasco, C., Guardiola, J., Munoz, L., Clariana, A. Lancet (1984) [Pubmed]
  7. Ambroxol inhibits doxorubicin-induced lipid peroxidation in heart of mice. Nowak, D., Pierscinski, G., Drzewoski, J. Free Radic. Biol. Med. (1995) [Pubmed]
  8. Antioxidant properties of Ambroxol. Nowak, D., Antczak, A., Król, M., Bialasiewicz, P., Pietras, T. Free Radic. Biol. Med. (1994) [Pubmed]
  9. A double-blind placebo controlled trial with oral ambroxol and N-acetylcysteine for mucolytic treatment in cystic fibrosis. Ratjen, F., Wönne, R., Posselt, H.G., Stöver, B., Hofmann, D., Bender, S.W. Eur. J. Pediatr. (1985) [Pubmed]
  10. Ambroxol improves the broncho-spasmolytic activity of clenbuterol in the guinea-pig. Pairet, M., Engelmann, P., Von Nicolai, H., Champeroux, P., Richard, S., Rauber, G., Engelhardt, G. J. Pharm. Pharmacol. (1997) [Pubmed]
  11. Protective effect of erdosteine against hypochlorous acid-induced acute lung injury and lipopolysaccharide-induced neutrophilic lung inflammation in mice. Hayashi, K., Hosoe, H., Kaise, T., Ohmori, K. J. Pharm. Pharmacol. (2000) [Pubmed]
  12. Attenuation by ambroxol of monochloramine-enhanced gastric carcinogenesis: a possible prevention against Helicobacter pylori-associated gastric carcinogenesis. Narahara, H., Tatsuta, M., Iishi, H., Baba, M., Mikuni, T., Uedo, N., Sakai, N., Yano, H. Cancer Lett. (2001) [Pubmed]
  13. Activity of bromhexine and ambroxol, semi-synthetic derivatives of vasicine from the Indian shrub Adhatoda vasica, against Mycobacterium tuberculosis in vitro. Grange, J.M., Snell, N.J. Journal of ethnopharmacology. (1996) [Pubmed]
  14. Depressant effect of ambroxol on stimulated functional responses and cell death in rat alveolar macrophages exposed to silica in vitro. Kim, Y.K., Jang, Y.Y., Han, E.S., Lee, C.S. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  15. Influence of cationic amphiphilic drugs on the phosphatidylcholine hydrolysis by phospholipase A2. Gräbner, R. Biochem. Pharmacol. (1987) [Pubmed]
  16. Ambroxol-induced modification of ion transport in human airway Calu-3 epithelia. Hasegawa, I., Niisato, N., Iwasaki, Y., Marunaka, Y. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  17. Pharmacokinetic properties of single-dose loratadine and ambroxol alone and combined in tablet formulations in healthy men. Villacampa, J., Alcántar, F., Rodríguez, J.M., Morales, J.M., Herrera, J., Rosete, R. Clinical therapeutics. (2003) [Pubmed]
  18. Erdosteine. Dechant, K.L., Noble, S. Drugs (1996) [Pubmed]
  19. 2-[(3-Pyridinylmethyl)thio]pyrimidine derivatives: new bronchosecretolytic agents. Schickaneder, H., Engler, H., Szelenyi, I. J. Med. Chem. (1987) [Pubmed]
  20. Inhibition of bleomycin-induced cell death in rat alveolar macrophages and human lung epithelial cells by ambroxol. Hong, J.S., Ko, H.H., Han, E.S., Lee, C.S. Biochem. Pharmacol. (2003) [Pubmed]
  21. In vitro inhibition of human neutrophil histotoxicity by ambroxol: evidence for a multistep mechanism. Ottonello, L., Arduino, N., Bertolotto, M., Dapino, P., Mancini, M., Dallegri, F. Br. J. Pharmacol. (2003) [Pubmed]
  22. Inhibition of inflammatory responses by ambroxol, a mucolytic agent, in a murine model of acute lung injury induced by lipopolysaccharide. Su, X., Wang, L., Song, Y., Bai, C. Intensive care medicine. (2004) [Pubmed]
  23. Ambroxol inhibits platelet-derived growth factor production in human monocytic cells. Utsugi, M., Dobashi, K., Koga, Y., Masubuchi, K., Shimizu, Y., Endou, K., Nakazawa, T., Mori, M. Eur. J. Pharmacol. (2002) [Pubmed]
  24. Effects of a beta adrenergic drug and a secretolytic agent on regional mucociliary clearance in patients with COLD. Weiss, T., Dorow, P., Felix, R. Chest (1981) [Pubmed]
  25. Identification of CYP3A4 as the predominant isoform responsible for the metabolism of ambroxol in human liver microsomes. Ishiguro, N., Senda, C., Kishimoto, W., Sakai, K., Funae, Y., Igarashi, T. Xenobiotica (2000) [Pubmed]
  26. Cell-specific modulation of surfactant proteins by ambroxol treatment. Seifart, C., Clostermann, U., Seifart, U., Müller, B., Vogelmeier, C., von Wichert, P., Fehrenbach, H. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
  27. High-performance liquid chromatographic determination of ambroxol in human plasma. Nobilis, M., Pastera, J., Svoboda, D., Kvêtina, J., Macek, K. J. Chromatogr. (1992) [Pubmed]
  28. Assay of ambroxol in human plasma by high-performance liquid chromatography with amperometric detection. Flores-Murrieta, F.J., Hoyo-Vadillo, C., Hong, E., Castañeda-Hernandez, G. J. Chromatogr. (1989) [Pubmed]
  29. Determination of ambroxol in biological material by gas chromatography with electron-capture detection. Colombo, L., Marcucci, F., Marini, G.M., Pierfederici, P., Mussini, E. J. Chromatogr. (1990) [Pubmed]
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