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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

glpT  -  sn-glycerol-3-phosphate transporter

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2232, JW2234
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Disease relevance of glpT


High impact information on glpT

  • The heterologous exchange showed a maximal velocity of 130 nmol/min/mg protein via the glpT system and 11 nmol/min/mg protein for the uhpT system [3].
  • The substrates of the phosphodiesterase had no affinity for the glpT-encoded active transport system [1].
  • In addition, two integration host factor (IHF) binding sites were identified downstream of the glpT transcriptional start site at positions +15 to +51 and +193 to +227 [4].
  • The recombinant plasmid carrying glpT was able to complement the isogenic glpT mutant to wild-type levels of G3P uptake and permitted growth on a selective medium with G3P as a major carbon source [2].
  • The nucleotide sequences of the glpT gene were determined both directly from PCR products and from the cloned DNA insert of strain Eagan [2].

Biological context of glpT

  • The cell-free system yielded a second protein that is likely to be also coded for by the glpT operon [5].
  • The presence of a functional glpT gene in Haemophilus influenzae could be questioned, since there is only what appears to be a truncated glpT (HI0686, 143 nt in the 5'-end) available in the H. influenzae Rd genome database (Fleischmann et al. , 1995) [2].

Associations of glpT with chemical compounds

  • Glucose and other phosphotransferase system sugars inhibit Pi efflux by repressing glpT expression [6].
  • The expression of recombinant plasmids carrying the glpA gene (anaerobic glycerol-3-phosphate dehydrogenase) and the closely linked glpT gene (glycerol 3-phosphate transport) were studied under aerobic and anaerobic conditions [7].

Analytical, diagnostic and therapeutic context of glpT

  • A Northern blot analysis showed that the glpT genes in both Eagan and Rd strains were transcribed on a RNA of approximately 1.4 kb in size [2].


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