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Gene Review

AKAP6  -  A kinase (PRKA) anchor protein 6

Homo sapiens

Synonyms: A-kinase anchor protein 100 kDa, A-kinase anchor protein 6, ADAP100, ADAP6, AKAP 100, ...
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Disease relevance of AKAP6

  • Recombinant AKAP100, expressed in Escherichia coli, binds RII alpha in a solid-phase overlay assay [1].
  • In the heart, signaling events such as the onset of cardiac hypertrophy are influenced by muscle-specific mAKAP signaling complexes that target protein kinase A (PKA), the cAMP-responsive guanine-nucleotide exchange factor EPAC and cAMP-selective phosphodiesterase 4 (PDE4) [2].

High impact information on AKAP6


Biological context of AKAP6


Anatomical context of AKAP6


Analytical, diagnostic and therapeutic context of AKAP6

  • AKAP100 was detected in preparations of RII purified from L6P cell extracts by cAMP-agarose affinity chromatography [1].
  • By immunoblotting, we identified AKAP100 in adult rat and human hearts, and showed that type I and II regulatory (RI and II) subunits of PKA are present in the rat heart [4].


  1. Cloning and characterization of A-kinase anchor protein 100 (AKAP100). A protein that targets A-kinase to the sarcoplasmic reticulum. McCartney, S., Little, B.M., Langeberg, L.K., Scott, J.D. J. Biol. Chem. (1995) [Pubmed]
  2. AKAP signaling complexes: getting to the heart of the matter. McConnachie, G., Langeberg, L.K., Scott, J.D. Trends in molecular medicine. (2006) [Pubmed]
  3. Spatial restriction of PDK1 activation cascades by anchoring to mAKAPalpha. Michel, J.J., Townley, I.K., Dodge-Kafka, K.L., Zhang, F., Kapiloff, M.S., Scott, J.D. Mol. Cell (2005) [Pubmed]
  4. A-kinase anchoring protein 100 (AKAP100) is localized in multiple subcellular compartments in the adult rat heart. Yang, J., Drazba, J.A., Ferguson, D.G., Bond, M. J. Cell Biol. (1998) [Pubmed]
  5. mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope. Kapiloff, M.S., Jackson, N., Airhart, N. J. Cell. Sci. (2001) [Pubmed]
  6. The mAKAP signaling complex: integration of cAMP, calcium, and MAP kinase signaling pathways. Dodge-Kafka, K.L., Kapiloff, M.S. Eur. J. Cell Biol. (2006) [Pubmed]
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