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Gene Review

asnA  -  asparagine synthetase A

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3738, JW3722
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Disease relevance of asnA


High impact information on asnA


Biological context of asnA

  • The stimulating effect of AsnC on asnA transcription is abolished by asparagine, while the autoregulation of asnC is not affected by asparagine [7].
  • As regards nontransgenic L. corniculatus plants, in one location flow of asnA transgene was detected up to 18 m from the 1.8 m2 donor plot [8].
  • Taken with known sequences for asnA and phoS this completes the sequence of a segment of about 17 kilobases or 0.4 min of the E. coli genome [9].

Associations of asnA with chemical compounds

  • The asnB gene is located near gal.AsnA+ asnB and asnA asnB+ strains were constructed, and the asparagine synthetic reaction was characterized in extracts [10].

Other interactions of asnA


  1. Overexpression and purification of asparagine synthetase from Escherichia coli. Sugiyama, A., Kato, H., Nishioka, T., Oda, J. Biosci. Biotechnol. Biochem. (1992) [Pubmed]
  2. Transfer RNA-dependent amino acid biosynthesis: an essential route to asparagine formation. Min, B., Pelaschier, J.T., Graham, D.E., Tumbula-Hansen, D., Söll, D. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Chromosomal replication origins (oriC) of Enterobacter aerogenes and Klebsiella pneumoniae are functional in Escherichia coli. Harding, N.E., Cleary, J.M., Smith, D.W., Michon, J.J., Brusilow, W.S., Zyskind, J.W. J. Bacteriol. (1982) [Pubmed]
  4. Cloning and expression of the Escherichia coli replication origin in a single-stranded DNA phage. Kaguni, J., LaVerne, L.S., Ray, D.S. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  5. The chromosomal origin of replication (oriC) of Erwinia carotovora. Takeda, Y., Harding, N.E., Smith, D.W., Zyskind, J.W. Nucleic Acids Res. (1982) [Pubmed]
  6. Nucleotide sequence of the asnA gene coding for asparagine synthetase of E. coli K-12. Nakamura, M., Yamada, M., Hirota, Y., Sugimoto, K., Oka, A., Takanami, M. Nucleic Acids Res. (1981) [Pubmed]
  7. AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli. Kölling, R., Lother, H. J. Bacteriol. (1985) [Pubmed]
  8. Measuring gene flow from two birdsfoot trefoil (Lotus corniculatus) field trials using transgenes as tracer markers. De Marchis, F., Bellucci, M., Arcioni, S. Mol. Ecol. (2003) [Pubmed]
  9. DNA sequence around the Escherichia coli unc operon. Completion of the sequence of a 17 kilobase segment containing asnA, oriC, unc, glmS and phoS. Walker, J.E., Gay, N.J., Saraste, M., Eberle, A.N. Biochem. J. (1984) [Pubmed]
  10. Genetic and biomedical studies demonstrating a second gene coding for asparagine synthetase in Escherichia coli. Humbert, R., Simoni, R.D. J. Bacteriol. (1980) [Pubmed]
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