Disease relevance of yjaZ

• We found that a new mutant with a deletion/replacement of the Escherichia coli K-12 htrC gene, a gene previously reported to be required for growth at elevated temperatures, is not temperature sensitive [1].
• Heat shock transcription of the groESL operon of Agrobacterium tumefaciens may involve a hairpin-loop structure [2].
• Heat shock (stress) proteins and autoimmunity in rheumatic diseases [3].
• PROBLEM: Heat shock proteins are expressed during early pregnancy and in peritoneal fluids from women with endometriosis [4].

High impact information on yjaZ

• Heat shock in Escherichia coli alters the protein-binding properties of the chaperonin groEL by inducing its phosphorylation [5].
• We looked for gene(s) which, when present in multicopy, prevent the constitutive heat shock response associated with htrC mutant bacteria or caused by the presence of puromycin [6].
• Heat shock proteins participate in the initiation of DNA replication of different organisms by facilitating the assembly of initiation complexes [7].
• Furthermore, the original mutants, kindly provided by the original authors, although temperature sensitive, do not have mutations in the open reading frame designated htrC [1].
• Heat shock gene expression is induced by a variety of environmental stresses, including the presence of many chemicals [8].

Biological context of yjaZ

• Inactivation of the htrC gene results in the inability to form colonies at 42 degrees C. An identical bacterial phenotype is found whether the htrC gene is inactivated either by Tn5 insertions or by a deletion spanning the entire gene [9].
• Heat shock attenuates endothelium-dependent vasodilation in skeletal muscle microcirculation [10].

Other interactions of yjaZ

• The htrC gene has been localized at 90 min, immediately downstream of the rpoC gene, and has been previously sequenced [9].

References