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Gene Review

nusG  -  transcription antitermination protein NusG

Escherichia coli UTI89

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Disease relevance of nusG


High impact information on nusG


Chemical compound and disease context of nusG


Biological context of nusG


Associations of nusG with chemical compounds


Physical interactions of nusG


Other interactions of nusG


Analytical, diagnostic and therapeutic context of nusG

  • We propose that an increased occurrence of chromosomal R-loops in the rho and nusG mutants leads to titration of a cyloplasmic host factor(s) that negatively modulates the stability of plasmid R-loop replication intermediates and consequently to runaway plasmid replication [20].


  1. A dnaC mutation in Escherichia coli that affects copy number of ColE1-like plasmids and the PriA-PriB (but not Rep-PriC) pathway of chromosomal replication restart. Harinarayanan, R., Gowrishankar, J. Genetics (2004) [Pubmed]
  2. The nusG gene of Streptomyces griseus: cloning of the gene and analysis of the A-factor binding properties of the gene product. Kuberski, S., Kasberg, T., Distler, J. FEMS Microbiol. Lett. (1994) [Pubmed]
  3. Identification of the gene encoding transcription factor NusG of Thermus thermophilus. Heinrich, T., Schröder, W., Erdmann, V.A., Hartmann, R.K. J. Bacteriol. (1992) [Pubmed]
  4. The nus mutations affect transcription termination in Escherichia coli. Ward, D.F., Gottesman, M.E. Nature (1981) [Pubmed]
  5. Crystal structure of AmiC: the controller of transcription antitermination in the amidase operon of Pseudomonas aeruginosa. Pearl, L., O'Hara, B., Drew, R., Wilson, S. EMBO J. (1994) [Pubmed]
  6. A bacterial gene involved in transcription antitermination: regulation at a rho-independent terminator in the bgl operon of E. coli. Mahadevan, S., Wright, A. Cell (1987) [Pubmed]
  7. Transcription antitermination by phage lambda gene Q protein requires a DNA segment spanning the RNA start site. Yang, X.J., Hart, C.M., Grayhack, E.J., Roberts, J.W. Genes Dev. (1987) [Pubmed]
  8. Functional conservation of cold shock domains in bacteria and higher plants. Nakaminami, K., Karlson, D.T., Imai, R. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  9. The RNA-protein complex: direct probing of the interfacial recognition dynamics and its correlation with biological functions. Xia, T., Becker, H.C., Wan, C., Frankel, A., Roberts, R.W., Zewail, A.H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  10. tRNA-mediated transcription antitermination in vitro: codon-anticodon pairing independent of the ribosome. Grundy, F.J., Winkler, W.C., Henkin, T.M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  11. The mechanism of tryptophan induction of tryptophanase operon expression: tryptophan inhibits release factor-mediated cleavage of TnaC-peptidyl-tRNA(Pro). Gong, F., Ito, K., Nakamura, Y., Yanofsky, C. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  12. The metIC operon involved in methionine biosynthesis in Bacillus subtilis is controlled by transcription antitermination. Auger, S., Yuen, W.H., Danchin, A., Martin-Verstraete, I. Microbiology (Reading, Engl.) (2002) [Pubmed]
  13. Mutations in the ss subunit of the Bacillus subtilis RNA polymerase that confer both rifampicin resistance and hypersensitivity to NusG. Ingham, C.J., Furneaux, P.A. Microbiology (Reading, Engl.) (2000) [Pubmed]
  14. The nucleic acid melting activity of Escherichia coli CspE is critical for transcription antitermination and cold acclimation of cells. Phadtare, S., Inouye, M., Severinov, K. J. Biol. Chem. (2002) [Pubmed]
  15. Regulation of the Escherichia coli K5 capsule gene cluster by transcription antitermination. Stevens, M.P., Clarke, B.R., Roberts, I.S. Mol. Microbiol. (1997) [Pubmed]
  16. N-mediated transcription antitermination in lambdoid phage H-19B is characterized by alternative NUT RNA structures and a reduced requirement for host factors. Neely, M.N., Friedman, D.I. Mol. Microbiol. (2000) [Pubmed]
  17. Characterization of the tryptophanase operon of Proteus vulgaris. Cloning, nucleotide sequence, amino acid homology, and in vitro synthesis of the leader peptide and regulatory analysis. Kamath, A.V., Yanofsky, C. J. Biol. Chem. (1992) [Pubmed]
  18. Bipartite function of a small RNA hairpin in transcription antitermination in bacteriophage lambda. Chattopadhyay, S., Garcia-Mena, J., DeVito, J., Wolska, K., Das, A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  19. Mapping of the Q-utilization site (qut) required for antitermination of late transcription in bacteriophage lambda. Somasekhar, G., Szybalski, W. Gene (1983) [Pubmed]
  20. Host factor titration by chromosomal R-loops as a mechanism for runaway plasmid replication in transcription termination-defective mutants of Escherichia coli. Harinarayanan, R., Gowrishankar, J. J. Mol. Biol. (2003) [Pubmed]
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