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Gene Review

NFE2L3  -  nuclear factor, erythroid 2-like 3

Homo sapiens

Synonyms: NF-E2-related factor 3, NFE2-related factor 3, NRF3, Nrf3, Nuclear factor erythroid 2-related factor 3, ...
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Disease relevance of NFE2L3


High impact information on NFE2L3


Biological context of NFE2L3


Anatomical context of NFE2L3

  • In particular, NRF3 is highly expressed in primary placental cytotrophoblasts, but not in placental fibroblasts [1].
  • Nrf3 transcripts then disappear from the heart and are next observed in the myotomal compartment of maturing somites, restricted to the medial portion along the rostrocaudal axis and fading after muscle precursors migrate [4].

Regulatory relationships of NFE2L3

  • Furthermore, we showed that NRF3 transcript and protein levels are induced by TNF-alpha in JAR cells [1].

Other interactions of NFE2L3

  • Using full-length human MAFG protein as bait, we identified the human basic-leucine zipper protein NRF3 [NF-E2 (nuclear factor erythroid 2)-related factor 3] as an interaction partner [1].

Analytical, diagnostic and therapeutic context of NFE2L3

  • Bandshift and supershift assays with in vitro transcribed and translated proteins and nuclear extracts from Hep-G2 cells treated with Me2SO and t-BHQ and immunoprecipitation assays demonstrated that Nrf3 associates with small Maf proteins to bind to the ARE [2].
  • Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3 [3].


  1. Functional and placental expression analysis of the human NRF3 transcription factor. Chénais, B., Derjuga, A., Massrieh, W., Red-Horse, K., Bellingard, V., Fisher, S.J., Blank, V. Mol. Endocrinol. (2005) [Pubmed]
  2. Nrf3 negatively regulates antioxidant-response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene. Sankaranarayanan, K., Jaiswal, A.K. J. Biol. Chem. (2004) [Pubmed]
  3. Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. Kobayashi, A., Ito, E., Toki, T., Kogame, K., Takahashi, S., Igarashi, K., Hayashi, N., Yamamoto, M. J. Biol. Chem. (1999) [Pubmed]
  4. The cap 'n' collar family member NF-E2-related factor 3 (Nrf3) is expressed in mesodermal derivatives of the avian embryo. Etchevers, H.C. Int. J. Dev. Biol. (2005) [Pubmed]
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