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Gene Review:

aldA - aldehyde dehydrogenase

Escherichia coli O157:H7 str. EDL933

Karaolis, D.K. et al., Pellicer, M.T. et al., Kulmburg, P. et al., Ma, L.C. et al., Felenbok, B. et al., et al.

Karaolis, Johnson, Bailey, Boedeker, Kaper, Reeves,

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Disease relevance of aldA

In addition, expression of other genes identified as members of the ToxR regulon (tcpA, tcpI, aldA, and tagA) can be activated in E. coli by the toxT gene product but not by ToxR [1].
The region containing aldA and tagA comprises 13 kb of previously unidentified DNA and is part of a PAI that contains a regulator of virulence genes (ToxT) and a gene cluster encoding an essential colonization factor and the cholera toxin phage receptor (toxin-coregulated pilus; TCP) [2].
CONCLUSION: The expression of the aldA gene is higher in K. pneumoniae strains from patients with liver abscess [3].

High impact information on aldA

ALCR is the specific activator of the Aspergillus nidulans ethanol-utilization pathway, mediating the induction of its own transcription and that of the structural genes alcA and aldA, encoding respectively, alcohol dehydrogenase I and aldehyde dehydrogenase [4].
By pulsed-field gel electrophoresis the 225-kb pXAU1 plasmid encoding aldA was shown to be linear [5].
In the 5' flanking region of the alcR gene, several repeats and inverted repeats were found, and small sequence similarities were also found with the 5' flanking regions of the alcA and aldA genes [6].
A second operon ( aldA) was also found which is transcribed divergently from pdc [7].
The promoter region of aldA contains two 10-bp sequences (5'-TGTTAATTAA-3') that perfectly match the proposed ArcA-P binding consensus (5'-[A/T]GTTAATTA[A/T]-3') [8].

Chemical compound and disease context of aldA

Aldehyde dehydrogenase, encoded by the aldA gene in Escherichia coli, is inactive in nitrosoguanidine induced mutant strain ECL40 and temperature-sensitive in spontaneous mutant strain JA104 [9].

Biological context of aldA

In this study we used the aldA promoter to test the validity of the proposed consensus sequence [8].
The aldA gene (encoding aldehyde dehydrogenase) of Escherichia coli is anaerobically repressed by ArcA-P, the phosphorylated response regulator of the ArcB/A two-component signal transduction system [8].

Associations of aldA with chemical compounds

The aldA gene encodes functional ALDH and can use glycolaldehyde and glyceraldehydes as substrates [3].

References

Regulatory cascade controls virulence in Vibrio cholerae. DiRita, V.J., Parsot, C., Jander, G., Mekalanos, J.J. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
A Vibrio cholerae pathogenicity island associated with epidemic and pandemic strains. Karaolis, D.K., Johnson, J.A., Bailey, C.C., Boedeker, E.C., Kaper, J.B., Reeves, P.R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
Molecular cloning and kinetic characterization of an aldehyde dehydrogenase gene in Klebsiella pneumoniae. Ma, L.C., Lee, S.L., Lee, C.Z., Yin, S.J., Wang, J.T. J. Formos. Med. Assoc. (2005) [Pubmed]
Specific binding sites for the activator protein, ALCR, in the alcA promoter of the ethanol regulon of Aspergillus nidulans. Kulmburg, P., Judewicz, N., Mathieu, M., Lenouvel, F., Sequeval, D., Felenbok, B. J. Biol. Chem. (1992) [Pubmed]
Cloning, sequence and expression of a linear plasmid-based and a chromosomal homolog of chloroacetaldehyde dehydrogenase-encoding genes in Xanthobacter autotrophicus GJ10. Bergeron, H., Labbé, D., Turmel, C., Lau, P.C. Gene (1998) [Pubmed]
The ethanol regulon in Aspergillus nidulans: characterization and sequence of the positive regulatory gene alcR. Felenbok, B., Sequeval, D., Mathieu, M., Sibley, S., Gwynne, D.I., Davies, R.W. Gene (1988) [Pubmed]
Pyruvate decarboxylase: a key enzyme for the oxidative metabolism of lactic acid by Acetobacter pasteurianus. Chandra Raj, K., Ingram, L.O., Maupin-Furlow, J.A. Arch. Microbiol. (2001) [Pubmed]
A mutational study of the ArcA-P binding sequences in the aldA promoter of Escherichia coli. Pellicer, M.T., Lynch, A.S., De Wulf, P., Boyd, D., Aguilar, J., Lin, E.C. Mol. Gen. Genet. (1999) [Pubmed]
Inactive and temperature-sensitive folding mutants of aldehyde dehydrogenase of Escherichia coli. Limón, A., Enjuanes, A., Aguilar, J. Int. Microbiol. (1999) [Pubmed]

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