The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Ceratopogonidae


High impact information on Ceratopogonidae

  • Together, these data indicate that the RGD motif present on BTV VP7 is responsible for Culicoides cell binding activity [1].
  • The purified VP5 protein was shown to be able to permeabilize mammalian and Culicoides insect cells, inducing cytotoxicity [4].
  • RGD-specific MAb H1.5, but not those directed to other regions of the core, inhibited the binding activity of CLPs to the Culicoides cell surface [1].
  • To test this hypothesis, variation in the consensus sequence and quasispecies heterogeneity of the VP2 and NS3/NS3A genes of a plaque-purified strain of BTV serotype 10 was determined during alternating infection of vector Culicoides sonorensis and a sheep and calf [5].
  • Sequences from the mitochondrial cytochrome oxidase subunit 2 gene (cox2) were determined for 14 species from the family Ceratopogonidae, representing 12 genera and all five subfamilies, along with six representatives of other nematoceran families [6].

Biological context of Ceratopogonidae


Anatomical context of Ceratopogonidae


Associations of Ceratopogonidae with chemical compounds

  • Light-weight net jackets treated with N,N-diethyl-m-toluamide (deet) were field-tested in Panama against five species of biting midges, principally Culicoides furens (Poey) and C. barbosai Wirth and Blanton [9].
  • Black flies (Eusimulium spp.), hippoboscid flies (Ornithomyia avicularia), mosquitoes (Culex pipiens pipiens) and biting midges (Culicoides spp.), trapped while attempting to feed on raptor nestlings, were found to contain trypanosomatids in their intestine [10].
  • Additionally, sLT generation with the Culicoides extract was measured at different times of the year in one IDH-affected animal and remained high even in winter, when the horse was asymptomatic. sLT and histamine release were determined in 10 horses in parallel [11].
  • These findings suggest a key role for PAF in oedema formation, but not inflammatory cell accumulation, induced by Culicoides antigen in the skin of sweet itch horses [3].
  • At Bet Dagan Culicoides imicola Kieffer, C [12].

Gene context of Ceratopogonidae

  • Identification and characterization of a cDNA clone encoding the heat shock protein (Hsp60) from the biting midge, Culicoides variipennis sonorensis Wirth and Jones [13].
  • Culicoides arakawae, the most common Culicoides sp. on chicken farms in East Asia, is an important blood-sucking insect and Leucocytozoon caulleryi vector [14].
  • The main vectors of AHS are culicoides [15].
  • A eucalyptus-based insect repellent (PMD) was evaluated against Culicoides impunctatus in Scotland in comparison with deet [16].
  • The number of Culicoides dropped sharply in April with the onset of cooler conditions [17].

Analytical, diagnostic and therapeutic context of Ceratopogonidae

  • Results showed that supplementation with flaxseed for 42 days in our experimental horses reduced the mean skin test response to Culicoides sp. This observation was concurrent with a significant decrease in the long-chain saturated fatty acids; behenic acid (22:0) and lignoceric acid (24:0), in the hair of horses receiving flaxseed [18].


  1. RGD tripeptide of bluetongue virus VP7 protein is responsible for core attachment to Culicoides cells. Tan, B.H., Nason, E., Staeuber, N., Jiang, W., Monastryrskaya, K., Roy, P. J. Virol. (2001) [Pubmed]
  2. Proteolytic cleavage of VP2, an outer capsid protein of African horse sickness virus, by species-specific serum proteases enhances infectivity in Culicoides. Marchi, P.R., Rawlings, P., Burroughs, J.N., Wellby, M., Mertens, P.P., Mellor, P.S., Wade-Evans, A.M. J. Gen. Virol. (1995) [Pubmed]
  3. Actions of PAF receptor antagonists in horses with the allergic skin disease sweet itch. Foster, A.P., Lees, P., Cunningham, F.M. Inflamm. Res. (1995) [Pubmed]
  4. Expression and functional characterization of bluetongue virus VP5 protein: role in cellular permeabilization. Hassan, S.H., Wirblich, C., Forzan, M., Roy, P. J. Virol. (2001) [Pubmed]
  5. Occurrence of genetic drift and founder effect during quasispecies evolution of the VP2 and NS3/NS3A genes of bluetongue virus upon passage between sheep, cattle, and Culicoides sonorensis. Bonneau, K.R., Mullens, B.A., MacLachlan, N.J. J. Virol. (2001) [Pubmed]
  6. Molecular analysis of the biting midges (Diptera: Ceratopogonidae), based on mitochondrial cytochrome oxidase subunit 2. Beckenbach, A.T., Borkent, A. Mol. Phylogenet. Evol. (2003) [Pubmed]
  7. Impact of biting midges on residential property values in Hervey Bay, Queensland, Australia. Ratnayake, J., Dale, P.E., Sipe, N.G., Daniels, P. J. Am. Mosq. Control Assoc. (2006) [Pubmed]
  8. Studies on Culicoides species of Nigeria. VII. The biology of some Nigerian Culicoides species. Dipeolu, O.O., Ogunrinade, A.F. Zeitschrift für Parasitenkunde (Berlin, Germany) (1977) [Pubmed]
  9. Insect repellent jacket tests against biting midges (diptera: Culicoides) in Panama. Harlan, H.J., Schreck, C.E., Kline, D.L. Am. J. Trop. Med. Hyg. (1983) [Pubmed]
  10. Trypanosoma avium of raptors (Falconiformes): phylogeny and identification of vectors. Votýpka, J., Oborník, M., Volf, P., Svobodová, M., Lukes, J. Parasitology (2002) [Pubmed]
  11. Sulfidoleukotriene generation from peripheral blood leukocytes of horses affected with insect bite dermal hypersensitivity. Marti, E., Urwyler, A., Neuenschwander, M., Eicher, R., Meier, D., de Weck, A.L., Gerber, H., Lazary, S., Dahinden, C.A. Vet. Immunol. Immunopathol. (1999) [Pubmed]
  12. Role of dogs (Canis domesticus) as hosts for African horse sickness virus. Braverman, Y., Chizov-Ginzburg, A. Vet. Microbiol. (1996) [Pubmed]
  13. Identification and characterization of a cDNA clone encoding the heat shock protein (Hsp60) from the biting midge, Culicoides variipennis sonorensis Wirth and Jones. Abdallah, M.A., Pollenz, R.S., Nunamaker, R.A., Murphy, K.E. Biochem. Genet. (2000) [Pubmed]
  14. Culicoides arakawae (Diptera: Ceratopogonidae) efficiently blood-fed and infected with Leucocytozoon caulleryi through a natural membrane. Yu, C.Y., Wang, J.S. Vet. Parasitol. (2001) [Pubmed]
  15. African horse sickness. House, J.A. Vet. Clin. North Am. Equine Pract. (1993) [Pubmed]
  16. Evaluation of a eucalyptus-based repellent against Culicoides impunctatus (Diptera:Ceratopogonidae) in Scotland. Trigg, J.K. J. Am. Mosq. Control Assoc. (1996) [Pubmed]
  17. Seasonal abundance and parity of Culicoides biting midges associated with livestock at Roma, Lesotho (Diptera: Ceratopogonidae). Venter, G.J., Sweatman, G.K. Onderstepoort J. Vet. Res. (1989) [Pubmed]
  18. Flaxseed (Linum usitatissimum) supplementation associated with reduced skin test lesional area in horses with Culicoides hypersensitivity. O'Neill, W., McKee, S., Clarke, A.F. Can. J. Vet. Res. (2002) [Pubmed]
WikiGenes - Universities