Disease relevance of Immunologic Surveillance

• The presence of antithyroid antibodies could be due to deposits of amiodarone in the thyroid gland, with a consequent release of antigen from the follicle cell, but only in those patients with genetically determined defects in immunological surveillance could an autoimmune thyroiditis, with consequent hypothyroidism, develop [1].

High impact information on Immunologic Surveillance

• Enhanced immunological surveillance in mice heterozygous at the H-2 gene complex [2].
• A 1,2-dimethylhydrazine dihydrochloride-induced rat gastrointestinal tract tumor model was used to study the phenomenon of immunologic surveillance [3].
• The immunological surveillance hypothesis was formulated prior to the realization of the fact that an individual's effector T cells generally only see neoantigen if it is appropriately presented in the context of self MHC glycoproteins [4].
• These results suggest that sympathetic nerve stimulation after PHx results in subsequent activation of NKT cells and that these NKT cells might be associated with immunologic surveillance during hepatocyte regeneration [5].
• In addition, it may play an important role in immunological surveillance for pathogens that survive in vacuolar compartments in APC [6].

Biological context of Immunologic Surveillance

• These results suggest that the down-regulation of MHC-I molecules by K5 gene expression during reactivation may be important for evading immunological surveillance in the host [7].

Associations of Immunologic Surveillance with chemical compounds

• Thus, the ability of the spleen to protect rats from the induction of malignant colon tumors induced by DMH is most likely due to preservation of immunologic surveillance in the host [8].
• Retinol might act as an effect modifier of the HPV-associated risk for cervical cancer; exposed women may require adequate levels for immunologic surveillance of HPV [9].
• The aggregated LNs in the above 3 regions therefore could provide immunological surveillance against caecal luminal contents [10].
• It is speculated that prednisone therapy for steroid-dependent intrinsic asthma may have caused a loss of "immunologic surveillance," which permitted development of malignancy in a previously benign condition [11].

Gene context of Immunologic Surveillance

• In addition, TGF-beta 2 can exert a variety of immunosuppressive effects, suggesting that the production of this molecule contributes to impaired immunological surveillance of tumor development [12].
• In response to immunologic stimuli, immunologic surveillance cells and cells of the microenvironment are capable of producing GM-CSF [13].
• Thus erythrocyte entrapment may protect potentially immunogenic agents from immunological surveillance [14].
• The ins and outs of CD1 molecules: bringing lipids under immunological surveillance [15].
• Infected NK-cell-specific CTLp frequencies of the patients were at undetectable levels despite their expression of latent membrane protein (LMP) 1, suggesting mechanisms to escape immunologic surveillance [16].

References