Disease relevance of Taeniasis

• Taenia solium taeniasis/cysticercosis is a zoonotic disease complex in which the pig is an obligate intermediate host [1].
• Sera from patients with fascioliasis, taeniasis, schistosomiasis, oxyuriasis, trichinellosis and ancyclostomiasis gave counts similar to cord serum controls [2].
• A treatment of taeniasis with mebendazole and praziquantel followed by a re-treatment with atabrine has been done in the field trial, and confirmed that praziquantel is highly effective agent against tapeworm infection, but mebendazole is not [3].
• Taeniasis with T solium can lead to neurocysticercosis and threaten others by accidental ingestion of eggs released from asymptomatic Taeniasis patients [4].

High impact information on Taeniasis

• T. solium and Taenia saginata eggs cannot be differentiated on the basis of morphology; thus, in order to improve existing methods for the diagnosis of taeniasis, we have developed highly sensitive, species-specific DNA probes which differentiate T. solium and T. saginata [5].
• Significant factors associated with NCC were: 1) being born outside Lima, 2) having raised pigs, 3) more than 20 years of age, 4) a history of seizures, and 5) a history of taeniasis [6].
• In order to evaluate the efficacy of albendazole for the treatment of taeniasis, regimens of 400 mg x 1 day, 800 mg x 2 days, 800 mg x 3 days, 1200 mg x 2 days, and 1200 mg x 3 days were compared [7].
• A study was made of the effect on taeniasis of mebendazole, a drug known to be highly active against a variety of nematode species parasitic in humans [8].
• Serum immunoblots for both T. solium Cysticercosis and T. solium Taeniasis were performed [9].

Chemical compound and disease context of Taeniasis

• The infection rate for human taeniasis was 2.7/1000 individuals at the University Hospital, 10/1000 in the southern provinces of Choluteca and Valle, and 0.6/1000 in Cortes and Atlantida in the north [10].
• Treatment of taeniasis consists of niclosamide followed by a purgative [11].
• Mepacrine therapy in niclosamide resistant taeniasis [12].
• Single dose treatment with aminosidine of human taeniasis [13].

Biological context of Taeniasis

• Epidemiology of Taenia solium taeniasis and cysticercosis in two rural Guatemalan communities [14].
• Handwashing frequency was correlated with T. solium Taeniasis sero-positivity [9].
• Based on these figures and on the data on porcine cysticercosis (prevalence: 11%) and human taeniasis (prevalence: 0.13%) collected in the same region, we conclude that T. solium cysticercosis is an endemic, but overlooked public health problem in West Cameroon [15].
• Here we review briefly the morphology, pathology, molecular biology, distribution and control options of taeniasis/cysticercosis in Asia and the Pacific and comment on the potential role which dogs may play in the transmission of T. solium [16].

Gene context of Taeniasis

• The sensitivities of both tests, to detect epilepsy or taeniasis, were low, but the specificity and the positive predictive value of the antigen-capture assay was high when used with the epileptics [17].
• Taenia saginata: polymerase chain reaction for taeniasis diagnosis in human fecal samples [18].

Analytical, diagnostic and therapeutic context of Taeniasis

• Control of Taenia solium taeniasis and cysticercosis by focus-oriented chemotherapy of taeniasis [19].

References