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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Comovirus

  • We compared the environment and dynamics of tryptophan side chains of empty capsids and ribonucleoprotein particles of two icosahedral viruses from the comovirus group: cowpea mosaic virus (CPMV) and bean pod mottle virus (BPMV) [1].
  • Sub-cellular fractions, isolated from cauliflower mosaic virus (CaMV)-infected turnip protoplasts, are capable of synthesising CaMV DNA in vitro on an endogenous template and of reverse transcribing oligo dT-primed cowpea mosaic virus RNA [2].
  • The coding sequence for the entire 200K polyprotein of cowpea mosaic virus (CPMV) B-RNA was expressed in insect cells by using baculovirus expression vectors [3].
  • Splenocytes isolated from C3H/HeJ mice infected with coxsackievirus B3 (CVB3) proliferated in vitro not only against a variety of enterovirus (CVB2, CVB3, CVB6, CVA16, PV1) antigens, but against comovirus (CPMV, BPMV) antigens as well [4].
  • The putative X2 protein contains a region with similarity to the comovirus 32 kDa protease co-factor (the only mature protein released from the N terminus of comovirus P1 polyproteins) and to the corresponding region of other nepovirus P1 polyproteins [5].

High impact information on Comovirus

  • Natural supramolecular building blocks. Cysteine-added mutants of cowpea mosaic virus [6].
  • The deduced amino acid sequence of the 5' ORF1 (nucleotides 605 to 6325) showed significant similarity to the RNA-dependent RNA polymerase, helicase, and protease domains of viruses from the picornavirus, comovirus, calicivirus, and sequivirus families, as well as to a novel group of insect-infecting RNA viruses [7].
  • The cowpea (Vigna unguiculata) line Arlington, inoculated with Cowpea mosaic virus (CPMV), showed no symptoms, and no infectivity or accumulation of capsid antigen was detected at several days after inoculation [8].
  • The NTP-binding motif in cowpea mosaic virus B polyprotein is essential for viral replication [9].
  • The transgenic tobacco plants expressing CP-P should provide valuable material for investigating comovirus polyprotein processing and capsid assembly in vivo [10].

Chemical compound and disease context of Comovirus


Gene context of Comovirus

  • Of the four proposed cleavage sites in BPMV RNA1 polyprotein, the one at the 32K/58K site (Q/A) is distinct for BPMV polyprotein and those at the 58K/VPg and VPg/24K junctions (Q/S and Q/M, respectively) are identical in all four comovirus polyproteins [16].
  • In an alternative expression system, the HC-Pro coding region was subcloned in-frame between the movement protein and large coat protein genes of RNA2 of Cowpea mosaic virus (CPMV) [17].
  • BACKGROUND & OBJECTIVES: Foreign peptide sequences can be inserted into the betaB-betaC loop of the cowpea mosaic virus (CPMV) small coat protein (SCP) to yield functional chimaeric viruses [18].


  1. Protein-RNA interactions and virus stability as probed by the dynamics of tryptophan side chains. Da Poian, A.T., Johnson, J.E., Silva, J.L. J. Biol. Chem. (2002) [Pubmed]
  2. Isolation of a fraction from cauliflower mosaic virus-infected protoplasts which is active in the synthesis of (+) and (-) strand viral DNA and reverse transcription of primed RNA templates. Thomas, C.M., Hull, R., Bryant, J.A., Maule, A.J. Nucleic Acids Res. (1985) [Pubmed]
  3. Synthesis of the complete 200K polyprotein encoded by cowpea mosaic virus B-RNA in insect cells. van Bokhoven, H., van Lent, J.W., Custers, R., Vlak, J.M., Wellink, J., van Kammen, A. J. Gen. Virol. (1992) [Pubmed]
  4. Comoviruses and enteroviruses share a T cell epitope. Beck, M.A., Tracy, S., Coller, B.A., Chapman, N.M., Hufnagel, G., Johnson, J.E., Lomonossoff, G. Virology (1992) [Pubmed]
  5. Proteolytic processing at a novel cleavage site in the N-terminal region of the tomato ringspot nepovirus RNA-1-encoded polyprotein in vitro. Wang, A., Sanfaçon, H. J. Gen. Virol. (2000) [Pubmed]
  6. Natural supramolecular building blocks. Cysteine-added mutants of cowpea mosaic virus. Wang, Q., Lin, T., Johnson, J.E., Finn, M.G. Chem. Biol. (2002) [Pubmed]
  7. Analysis of the complete genome sequence of acute bee paralysis virus shows that it belongs to the novel group of insect-infecting RNA viruses. Govan, V.A., Leat, N., Allsopp, M., Davison, S. Virology (2000) [Pubmed]
  8. Evidence for participation of RNA 1-encoded elicitor in Cowpea mosaic virus-mediated concurrent protection. Bruening, G., Buzayan, J.M., Ferreiro, C., Lim, W. Virology (2000) [Pubmed]
  9. The NTP-binding motif in cowpea mosaic virus B polyprotein is essential for viral replication. Peters, S.A., Verver, J., Nollen, E.A., van Lent, J.W., Wellink, J., van Kammen, A. J. Gen. Virol. (1994) [Pubmed]
  10. Expression of cowpea mosaic virus coat protein precursor in transgenic tobacco plants. Nida, D.L., Anjos, J.R., Lomonossoff, G.P., Ghabrial, S.A. J. Gen. Virol. (1992) [Pubmed]
  11. The inhibition of cowpea mosaic virus replication by actinomycin D. Rottier, P.J., Rezelman, G., van Kammen, A. Virology (1979) [Pubmed]
  12. The ATP requirement for initiation of eukaryotic translation varies according to the mRNA species. Jackson, R.J. Eur. J. Biochem. (1991) [Pubmed]
  13. Pseudomonas aeruginosa outer-membrane protein F epitopes are highly immunogenic in mice when expressed on a plant virus. Brennan, F.R., Jones, T.D., Gilleland, L.B., Bellaby, T., Xu, F., North, P.C., Thompson, A., Staczek, J., Lin, T., Johnson, J.E., Hamilton, W.D., Gilleland, H.E. Microbiology (Reading, Engl.) (1999) [Pubmed]
  14. Stimulation of neutralizing antibodies to human immunodeficiency virus type 1 in three strains of mice immunized with a 22 amino acid peptide of gp41 expressed on the surface of a plant virus. McLain, L., Durrani, Z., Wisniewski, L.A., Porta, C., Lomonossoff, G.P., Dimmock, N.J. Vaccine (1996) [Pubmed]
  15. Hybrid virus-polymer materials. 1. Synthesis and properties of PEG-decorated cowpea mosaic virus. Raja, K.S., Wang, Q., Gonzalez, M.J., Manchester, M., Johnson, J.E., Finn, M.G. Biomacromolecules (2003) [Pubmed]
  16. Complete nucleotide sequence of bean pod mottle virus RNA1: sequence comparisons and evolutionary relationships to other comoviruses. Di, R., Hu, C.C., Ghabrial, S.A. Virus Genes (1999) [Pubmed]
  17. Subcellular location of the helper component-proteinase of Cowpea aphid-borne mosaic virus. Mlotshwa, S., Verver, J., Sithole-Niang, I., Gopinath, K., Carette, J., van Kammen, A., Wellink, J. Virus Genes (2002) [Pubmed]
  18. Expression & immunogenicity of malaria merozoite peptides displayed on the small coat protein of chimaeric cowpea mosaic virus. Yasawardene, S.G., Lomonossoff, G.P., Ramasamy, R. Indian J. Med. Res. (2003) [Pubmed]
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