The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Comovirus

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Comovirus

  • We compared the environment and dynamics of tryptophan side chains of empty capsids and ribonucleoprotein particles of two icosahedral viruses from the comovirus group: cowpea mosaic virus (CPMV) and bean pod mottle virus (BPMV) [1].
  • Sub-cellular fractions, isolated from cauliflower mosaic virus (CaMV)-infected turnip protoplasts, are capable of synthesising CaMV DNA in vitro on an endogenous template and of reverse transcribing oligo dT-primed cowpea mosaic virus RNA [2].
  • The coding sequence for the entire 200K polyprotein of cowpea mosaic virus (CPMV) B-RNA was expressed in insect cells by using baculovirus expression vectors [3].
  • Splenocytes isolated from C3H/HeJ mice infected with coxsackievirus B3 (CVB3) proliferated in vitro not only against a variety of enterovirus (CVB2, CVB3, CVB6, CVA16, PV1) antigens, but against comovirus (CPMV, BPMV) antigens as well [4].
  • The putative X2 protein contains a region with similarity to the comovirus 32 kDa protease co-factor (the only mature protein released from the N terminus of comovirus P1 polyproteins) and to the corresponding region of other nepovirus P1 polyproteins [5].
 

High impact information on Comovirus

  • Natural supramolecular building blocks. Cysteine-added mutants of cowpea mosaic virus [6].
  • The deduced amino acid sequence of the 5' ORF1 (nucleotides 605 to 6325) showed significant similarity to the RNA-dependent RNA polymerase, helicase, and protease domains of viruses from the picornavirus, comovirus, calicivirus, and sequivirus families, as well as to a novel group of insect-infecting RNA viruses [7].
  • The cowpea (Vigna unguiculata) line Arlington, inoculated with Cowpea mosaic virus (CPMV), showed no symptoms, and no infectivity or accumulation of capsid antigen was detected at several days after inoculation [8].
  • The NTP-binding motif in cowpea mosaic virus B polyprotein is essential for viral replication [9].
  • The transgenic tobacco plants expressing CP-P should provide valuable material for investigating comovirus polyprotein processing and capsid assembly in vivo [10].
 

Chemical compound and disease context of Comovirus

 

Gene context of Comovirus

  • Of the four proposed cleavage sites in BPMV RNA1 polyprotein, the one at the 32K/58K site (Q/A) is distinct for BPMV polyprotein and those at the 58K/VPg and VPg/24K junctions (Q/S and Q/M, respectively) are identical in all four comovirus polyproteins [16].
  • In an alternative expression system, the HC-Pro coding region was subcloned in-frame between the movement protein and large coat protein genes of RNA2 of Cowpea mosaic virus (CPMV) [17].
  • BACKGROUND & OBJECTIVES: Foreign peptide sequences can be inserted into the betaB-betaC loop of the cowpea mosaic virus (CPMV) small coat protein (SCP) to yield functional chimaeric viruses [18].

References

  1. Protein-RNA interactions and virus stability as probed by the dynamics of tryptophan side chains. Da Poian, A.T., Johnson, J.E., Silva, J.L. J. Biol. Chem. (2002) [Pubmed]
  2. Isolation of a fraction from cauliflower mosaic virus-infected protoplasts which is active in the synthesis of (+) and (-) strand viral DNA and reverse transcription of primed RNA templates. Thomas, C.M., Hull, R., Bryant, J.A., Maule, A.J. Nucleic Acids Res. (1985) [Pubmed]
  3. Synthesis of the complete 200K polyprotein encoded by cowpea mosaic virus B-RNA in insect cells. van Bokhoven, H., van Lent, J.W., Custers, R., Vlak, J.M., Wellink, J., van Kammen, A. J. Gen. Virol. (1992) [Pubmed]
  4. Comoviruses and enteroviruses share a T cell epitope. Beck, M.A., Tracy, S., Coller, B.A., Chapman, N.M., Hufnagel, G., Johnson, J.E., Lomonossoff, G. Virology (1992) [Pubmed]
  5. Proteolytic processing at a novel cleavage site in the N-terminal region of the tomato ringspot nepovirus RNA-1-encoded polyprotein in vitro. Wang, A., Sanfaçon, H. J. Gen. Virol. (2000) [Pubmed]
  6. Natural supramolecular building blocks. Cysteine-added mutants of cowpea mosaic virus. Wang, Q., Lin, T., Johnson, J.E., Finn, M.G. Chem. Biol. (2002) [Pubmed]
  7. Analysis of the complete genome sequence of acute bee paralysis virus shows that it belongs to the novel group of insect-infecting RNA viruses. Govan, V.A., Leat, N., Allsopp, M., Davison, S. Virology (2000) [Pubmed]
  8. Evidence for participation of RNA 1-encoded elicitor in Cowpea mosaic virus-mediated concurrent protection. Bruening, G., Buzayan, J.M., Ferreiro, C., Lim, W. Virology (2000) [Pubmed]
  9. The NTP-binding motif in cowpea mosaic virus B polyprotein is essential for viral replication. Peters, S.A., Verver, J., Nollen, E.A., van Lent, J.W., Wellink, J., van Kammen, A. J. Gen. Virol. (1994) [Pubmed]
  10. Expression of cowpea mosaic virus coat protein precursor in transgenic tobacco plants. Nida, D.L., Anjos, J.R., Lomonossoff, G.P., Ghabrial, S.A. J. Gen. Virol. (1992) [Pubmed]
  11. The inhibition of cowpea mosaic virus replication by actinomycin D. Rottier, P.J., Rezelman, G., van Kammen, A. Virology (1979) [Pubmed]
  12. The ATP requirement for initiation of eukaryotic translation varies according to the mRNA species. Jackson, R.J. Eur. J. Biochem. (1991) [Pubmed]
  13. Pseudomonas aeruginosa outer-membrane protein F epitopes are highly immunogenic in mice when expressed on a plant virus. Brennan, F.R., Jones, T.D., Gilleland, L.B., Bellaby, T., Xu, F., North, P.C., Thompson, A., Staczek, J., Lin, T., Johnson, J.E., Hamilton, W.D., Gilleland, H.E. Microbiology (Reading, Engl.) (1999) [Pubmed]
  14. Stimulation of neutralizing antibodies to human immunodeficiency virus type 1 in three strains of mice immunized with a 22 amino acid peptide of gp41 expressed on the surface of a plant virus. McLain, L., Durrani, Z., Wisniewski, L.A., Porta, C., Lomonossoff, G.P., Dimmock, N.J. Vaccine (1996) [Pubmed]
  15. Hybrid virus-polymer materials. 1. Synthesis and properties of PEG-decorated cowpea mosaic virus. Raja, K.S., Wang, Q., Gonzalez, M.J., Manchester, M., Johnson, J.E., Finn, M.G. Biomacromolecules (2003) [Pubmed]
  16. Complete nucleotide sequence of bean pod mottle virus RNA1: sequence comparisons and evolutionary relationships to other comoviruses. Di, R., Hu, C.C., Ghabrial, S.A. Virus Genes (1999) [Pubmed]
  17. Subcellular location of the helper component-proteinase of Cowpea aphid-borne mosaic virus. Mlotshwa, S., Verver, J., Sithole-Niang, I., Gopinath, K., Carette, J., van Kammen, A., Wellink, J. Virus Genes (2002) [Pubmed]
  18. Expression & immunogenicity of malaria merozoite peptides displayed on the small coat protein of chimaeric cowpea mosaic virus. Yasawardene, S.G., Lomonossoff, G.P., Ramasamy, R. Indian J. Med. Res. (2003) [Pubmed]
 
WikiGenes - Universities