Disease relevance of Angiomyoma

• Cutaneous angiomyolipomas are HMB45 negative, not associated with tuberous sclerosis, and should be considered as angioleiomyomas with fat [1].
• For comparison, sex steroid receptors were studied in 10 cases of cutaneous cavernous hemangioma and in 10 cases of subcutaneous angioleiomyoma [2].
• 5/5 (100%) arrector pili hamartomas, 10/12 (83%) piloleiomyomas, 4/5 (80%) piloleiomyosarcomas, 1/1 (100%) angioleiomyoma, and 1/7 (14%) angioleiomyosarcomas were positive for desmin [3].

High impact information on Angiomyoma

• The author proposes that cutaneous angiomyolipomas should be termed angioleiomyoma with fat to avoid confusion with unrelated non-cutaneous angiomyolipomas that are HMB45 negative and require investigation for tuberous sclerosis [1].
• Lack of CD34 positive stromal cells within angiomyomas (vascular leiomyomas) [4].
• METHODS: Histochemical analysis using monoclonal antibodies to CD34 and CD31 was performed in 10 angiomyomas and their adjacent soft tissue [4].
• On hematoxylin and eosin staining, areas consistent with an angioleiomyoma were found as well [5].
• Autocrine/paracrine involvement of parathyroid hormone-related peptide in vascular leiomyoma [6].

Anatomical context of Angiomyoma

• Progesterone receptor expression in angioleiomyoma of the nasal cavity [7].
• These results support the hypothesis that PTHrP acts through the PTH/PTHrP-receptor via an autocrine and/or paracrine mechanism from VSMC to endothelial cells in the formation of characteristic microenvironments of vascular leiomyoma cell composition [6].

Gene context of Angiomyoma

• Primary angioleiomyoma of the iliac bone: clinical pathological study of one case with flow cytometric DNA content and S-phase fraction analysis [8].

References