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Chemical Compound Review

Astatine-211     astatine

Synonyms: Astatine 211, AC1O3THU, 15755-39-2, Astatine, isotope of mass 211
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Disease relevance of astatine


High impact information on astatine


Chemical compound and disease context of astatine


Biological context of astatine


Anatomical context of astatine


Gene context of astatine

  • In this study we investigated the role of human NIS for cellular uptake of the high LET alpha-emitter astatine-211 ((211)At) in comparison with radioiodine as a potential radionuclide for future applications [18].

Analytical, diagnostic and therapeutic context of astatine


  1. Effective treatment of a murine model of adult T-cell leukemia using 211At-7G7/B6 and its combination with unmodified anti-Tac (daclizumab) directed toward CD25. Zhang, Z., Zhang, M., Garmestani, K., Talanov, V.S., Plascjak, P.S., Beck, B., Goldman, C., Brechbiel, M.W., Waldmann, T.A. Blood (2006) [Pubmed]
  2. 211At-methylene blue for targeted radiotherapy of human melanoma xenografts: treatment of micrometastases. Link, E.M., Carpenter, R.N. Cancer Res. (1990) [Pubmed]
  3. Astatine-211-labeled antibodies for treatment of disseminated ovarian cancer: an overview of results in an ovarian tumor model. Andersson, H., Elgqvist, J., Horvath, G., Hultborn, R., Jacobsson, L., Jensen, H., Karlsson, B., Lindegren, S., Palm, S. Clin. Cancer Res. (2003) [Pubmed]
  4. Cytotoxicity of alpha-particle-emitting astatine-211-labelled antibody in tumour spheroids: no effect of hyperthermia. Hauck, M.L., Larsen, R.H., Welsh, P.C., Zalutsky, M.R. Br. J. Cancer (1998) [Pubmed]
  5. The cytotoxicity and microdosimetry of astatine-211-labeled chimeric monoclonal antibodies in human glioma and melanoma cells in vitro. Larsen, R.H., Akabani, G., Welsh, P., Zalutsky, M.R. Radiat. Res. (1998) [Pubmed]
  6. Selective targeting of tumour neovasculature by a radiohalogenated human antibody fragment specific for the ED-B domain of fibronectin. Demartis, S., Tarli, L., Borsi, L., Zardi, L., Neri, D. European journal of nuclear medicine. (2001) [Pubmed]
  7. Survival and DNA damage in Chinese hamster V79 cells exposed to alpha particles emitted by DNA-incorporated astatine-211. Walicka, M.A., Vaidyanathan, G., Zalutsky, M.R., Adelstein, S.J., Kassis, A.I. Radiat. Res. (1998) [Pubmed]
  8. Microdosimetry of astatine-211 using histological images: application to bone marrow. Akabani, G., Zalutsky, M.R. Radiat. Res. (1997) [Pubmed]
  9. Inactivation of human osteosarcoma cells in vitro by 211At-TP-3 monoclonal antibody: comparison with astatine-211-labeled bovine serum albumin, free astatine-211 and external-beam X rays. Larsen, R.H., Bruland, O.S., Hoff, P., Alstad, J., Lindmo, T., Rofstad, E.K. Radiat. Res. (1994) [Pubmed]
  10. [211At]methylene blue for targeted radiotherapy of human melanoma xenografts: dose fractionation in the treatment of cutaneous tumours. Link, E.M., Carpenter, R.N., Hansen, G. Eur. J. Cancer (1996) [Pubmed]
  11. Preliminary observations of malignant melanoma therapy using radiolabeled alpha-methyltyrosine. McLaughlin, W.H., Thramann, W.M., Lambrecht, R.M., Milius, R.A., Bloomer, W.D. Journal of surgical oncology. (1988) [Pubmed]
  12. The in vitro radiobiology of astatine-211 decay. Kassis, A.I., Harris, C.R., Adelstein, S.J., Ruth, T.J., Lambrecht, R., Wolf, A.P. Radiat. Res. (1986) [Pubmed]
  13. Cell growth kinetics of the human cell line Colo-205 irradiated with photons and astatine-211 alpha-particles. Palm, S., Andersson, H., Bäck, T., Claesson, I., Delle, U., Hultborn, R., Jacobsson, L., Köpf, I., Lindegren, S. Anticancer Res. (2000) [Pubmed]
  14. Single-cell irradiation from [211At] astatine-labeled C215 monoclonal antibody: improved estimates of radiosensitivity from measurements on cellular uptake and retention. Palm, S., Bäck, T., Claesson, I., Delle, U., Hultborn, R., Lindegren, S., Jacobsson, L. Anticancer Res. (2003) [Pubmed]
  15. Tissue distribution and radiation dosimetry of astatine-211-labeled chimeric 81C6, an alpha-particle-emitting immunoconjugate. Zalutsky, M.R., Stabin, M.G., Larsen, R.H., Bigner, D.D. Nucl. Med. Biol. (1997) [Pubmed]
  16. Relative concentration of astatine-211 and iodine-125 by human fetal thyroid and carcinoma of the thyroid in nude mice. Cobb, L.M., Harrison, A., Dudley, N.E., Carr, T.E., Humphreys, J.A. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (1988) [Pubmed]
  17. Effects of the alpha-particle emitter At-211 and low-dose-rate gamma-radiation on the human cell line Colo-205 as studied with a growth assay. Palm, S., Bäck, T., Claesson, I., Delle, U., Hultborn, R., Jacobsson, L., Köpf, I., Lindegren, S. Anticancer Res. (1998) [Pubmed]
  18. Establishment of radioactive astatine and iodine uptake in cancer cell lines expressing the human sodium/iodide symporter. Petrich, T., Helmeke, H.J., Meyer, G.J., Knapp, W.H., Pötter, E. Eur. J. Nucl. Med. Mol. Imaging (2002) [Pubmed]
  19. Astatine-211-labeled radiotherapeutics: an emerging approach to targeted alpha-particle radiotherapy. Zalutsky, M.R., Vaidyanathan, G. Curr. Pharm. Des. (2000) [Pubmed]
  20. A microdosimetric model of astatine-211 labeled antibodies for radioimmunotherapy. Humm, J.L. Int. J. Radiat. Oncol. Biol. Phys. (1987) [Pubmed]
  21. Measuring astatine-211 distributions with SPECT. Turkington, T.G., Zalutsky, M.R., Jaszczak, R.J., Garg, P.K., Vaidyanathan, G., Coleman, R.E. Physics in medicine and biology. (1993) [Pubmed]
  22. Targeting disseminated melanoma with radiolabelled methylene blue: Comparative bio-distribution studies in man and animals. Link, E.M., Costa, D.C., Lui, D., Ell, P.J., Blower, P.J., Spittle, M.F. Acta oncologica (Stockholm, Sweden) (1996) [Pubmed]
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