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Gene Review

SSB  -  Sjogren syndrome antigen B (autoantigen La)

Homo sapiens

Synonyms: LARP3, La, La autoantigen, La ribonucleoprotein, La/SSB, ...
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Disease relevance of SSB


Psychiatry related information on SSB

  • Anti-cpep F(ab')(2 )bound to a common idiotype (Id) located within or spatially close to the antigen combining site of anti La/SSB (anti-pep) antibodies [6].

High impact information on SSB


Chemical compound and disease context of SSB


Biological context of SSB


Anatomical context of SSB

  • The function of SSB T cells in controls remains to be defined [3].
  • To identify the autoepitopes with which the ANA anti-La (anti-SS-B) reacts, we isolated a 1.4-kb cDNA clone for La from a lambda gt10 library made from a human Burkitt's cell line [18].
  • Hepatitis C virus internal ribosome entry site-mediated translation is stimulated by specific interaction of independent regions of human La autoantigen [19].
  • The La (SS-B) autoantigen is an evolutionarily conserved phosphoprotein which plays an important role, most likely as an RNA chaperone, in various processes, such as the biosynthesis and maturation of RNA polymerase III transcripts in the cell nucleus and (internal) initiation of translation in the cytoplasm [20].
  • These results show that autoantigens fodrin, SS-A (Ro) and SS-B (La) in human salivary gland cells undergo a striking redistribution during apoptosis and relocate to the cell membrane of apoptotic cells [21].

Associations of SSB with chemical compounds

  • UVB light and 17-beta-estradiol have different effects on the mRNA expression of Ro/SSA and La/SSB autoantigens in HaCaT cells [4].
  • This region of EcoSSB is composed of two parts: a glycine and proline-rich sequence of approximately 60 amino acids followed by an acidic region of the last 10 amino acids which is highly conserved among the bacterial SSB proteins [22].
  • Among the symptomatic group, the most common autoantibodies were histone ribosomal phosphate, SSA, SSB, Scl-70, cardiolipin, phosphatidylserine, GM2-ganglioside, and NC-1 [23].
  • Antithyroid peroxidase (20 patients), parietal cell (15), smooth muscle (14), reticulin (9), mitochondrial (5), striational (2), SSB (2) and SCL-70 (1) autoantibodies were detected in some specimens [24].
  • The sequence 349-368 aa represents the major B-cell epitope of La/SSB, also it contains, at position 366, a serine amino acid residue which constitutes the main phosphorylation site of the protein [25].

Physical interactions of SSB


Regulatory relationships of SSB

  • The specificity for human SSB in SV40 DNA replication can be explained, at least in part, by the finding that DNA polymerase alpha was stimulated 10-fold by human SSB but not by other SSBs [30].

Other interactions of SSB


Analytical, diagnostic and therapeutic context of SSB


  1. Isolation of a DNA helicase from HeLa cells requiring the multisubunit human single-stranded DNA-binding protein for activity. Seo, Y.S., Lee, S.H., Hurwitz, J. J. Biol. Chem. (1991) [Pubmed]
  2. Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A. Shen, J.C., Gray, M.D., Oshima, J., Loeb, L.A. Nucleic Acids Res. (1998) [Pubmed]
  3. T cell reactivity to Sjögren's syndrome related antigen La(SSB). Helsloot, J., Sturgess, A. J. Rheumatol. (1997) [Pubmed]
  4. UVB light and 17-beta-estradiol have different effects on the mRNA expression of Ro/SSA and La/SSB autoantigens in HaCaT cells. Szegedi, A., Irinyi, B., Bessenyei, B., Márka, M., Hunyadi, J., Semsei, I. Arch. Dermatol. Res. (2001) [Pubmed]
  5. Mapping of the 70 kDa, 34 kDa, and 11 kDa subunit genes of the human multimeric single-stranded DNA binding protein (hSSB/RPA) to chromosome bands 17p13, 1p35-p36.1, and 7p21-p22. Ozawa, K., Dean, F.B., Chen, M., Lee, S.H., Shiratori, A., Murakami, Y., Sakakura, T., Hurwitz, J., Eki, T. Cell Struct. Funct. (1993) [Pubmed]
  6. Unmasking the anti-La/SSB response in sera from patients with Sjogren's syndrome by specific blocking of anti-idiotypic antibodies to La/SSB antigenic determinants. Routsias, J.G., Touloupi, E., Dotsika, E., Moulia, A., Tsikaris, V., Sakarellos, C., Sakarellos-Daitsiotis, M., Moutsopoulos, H.M., Tzioufas, A.G. Mol. Med. (2002) [Pubmed]
  7. Requirement for the replication protein SSB in human DNA excision repair. Coverley, D., Kenny, M.K., Munn, M., Rupp, W.D., Lane, D.P., Wood, R.D. Nature (1991) [Pubmed]
  8. Hierarchical self-tolerance to T cell determinants within the ubiquitous nuclear self-antigen La (SS-B) permits induction of systemic autoimmunity in normal mice. Reynolds, P., Gordon, T.P., Purcell, A.W., Jackson, D.C., McCluskey, J. J. Exp. Med. (1996) [Pubmed]
  9. Estradiol enhances binding to cultured human keratinocytes of antibodies specific for SS-A/Ro and SS-B/La. Another possible mechanism for estradiol influence of lupus erythematosus. Furukawa, F., Lyons, M.B., Lee, L.A., Coulter, S.N., Norris, D.A. J. Immunol. (1988) [Pubmed]
  10. Pyrimidine tract binding protein and La autoantigen interact differently with the 5' untranslated regions of lentiviruses and oncoretrovirus mRNAs. Waysbort, A., Bonnal, S., Audigier, S., Estève, J.P., Prats, A.C. FEBS Lett. (2001) [Pubmed]
  11. Systemic lupus erythematosus and pregnancy. Molad, Y. Curr. Opin. Obstet. Gynecol. (2006) [Pubmed]
  12. A study of 20 SLE patients with intravenous immunoglobulin--clinical and serologic response. Levy, Y., Sherer, Y., Ahmed, A., Langevitz, P., George, J., Fabbrizzi, F., Terryberry, J., Meissner, M., Lorber, M., Peter, J.B., Shoenfeld, Y. Lupus (1999) [Pubmed]
  13. Differential single- versus double-strand DNA breakage produced by doxorubicin and its morpholinyl analogues. Duran, G.E., Lau, D.H., Lewis, A.D., Kühl, J.S., Bämmler, T.K., Sikic, B.I. Cancer Chemother. Pharmacol. (1996) [Pubmed]
  14. One gene, two transcripts: isolation of an alternative transcript encoding for the autoantigen La/SS-B from a cDNA library of a patient with primary Sjögrens' syndrome. Tröster, H., Metzger, T.E., Semsei, I., Schwemmle, M., Winterpacht, A., Zabel, B., Bachmann, M. J. Exp. Med. (1994) [Pubmed]
  15. Fine epitope mapping of the human SS-B/La protein. Identification of a distinct autoepitope homologous to a viral gag polyprotein. Kohsaka, H., Yamamoto, K., Fujii, H., Miura, H., Miyasaka, N., Nishioka, K., Miyamoto, T. J. Clin. Invest. (1990) [Pubmed]
  16. Exposure and binding of selected immunodominant La/SSB epitopes on human apoptotic cells. Neufing, P.J., Clancy, R.M., Jackson, M.W., Tran, H.B., Buyon, J.P., Gordon, T.P. Arthritis Rheum. (2005) [Pubmed]
  17. Genomic structure and amino acid sequence domains of the human La autoantigen. Chambers, J.C., Kenan, D., Martin, B.J., Keene, J.D. J. Biol. Chem. (1988) [Pubmed]
  18. Characteristics and epitope mapping of a cloned human autoantigen La. Sturgess, A.D., Peterson, M.G., McNeilage, L.J., Whittingham, S., Coppel, R.L. J. Immunol. (1988) [Pubmed]
  19. Hepatitis C virus internal ribosome entry site-mediated translation is stimulated by specific interaction of independent regions of human La autoantigen. Pudi, R., Abhiman, S., Srinivasan, N., Das, S. J. Biol. Chem. (2003) [Pubmed]
  20. Detailed analysis of the phosphorylation of the human La (SS-B) autoantigen. (De)phosphorylation does not affect its subcellular distribution. Broekhuis, C.H., Neubauer, G., van der Heijden, A., Mann, M., Proud, C.G., van Venrooij, W.J., Pruijn, G.J. Biochemistry (2000) [Pubmed]
  21. Intracellular trafficking and surface expression of SS-A (Ro), SS-B (La), poly(ADP-ribose) polymerase and alpha-fodrin autoantigens during apoptosis in human salivary gland cells induced by tumour necrosis factor-alpha. McArthur, C., Wang, Y., Veno, P., Zhang, J., Fiorella, R. Arch. Oral Biol. (2002) [Pubmed]
  22. In vitro and in vivo function of the C-terminus of Escherichia coli single-stranded DNA binding protein. Curth, U., Genschel, J., Urbanke, C., Greipel, J. Nucleic Acids Res. (1996) [Pubmed]
  23. A comparison of autoantibody production in asymptomatic and symptomatic women with silicone breast implants. Zandman-Goddard, G., Blank, M., Ehrenfeld, M., Gilburd, B., Peter, J., Shoenfeld, Y. J. Rheumatol. (1999) [Pubmed]
  24. Autoantibodies in early seropositive rheumatoid arthritis, before and during disease modifying antirheumatic drug treatment. Paulus, H.E., Wiesner, J., Bulpitt, K.J., Patnaik, M., Law, J., Park, G.S., Wong, W.K. J. Rheumatol. (2002) [Pubmed]
  25. Preferential recognition of the phosphorylated major linear B-cell epitope of La/SSB 349-368 aa by anti-La/SSB autoantibodies from patients with systemic autoimmune diseases. Terzoglou, A.G., Routsias, J.G., Avrameas, S., Moutsopoulos, H.M., Tzioufas, A.G. Clin. Exp. Immunol. (2006) [Pubmed]
  26. Mammalian peptidylglycine alpha-amidating monooxygenase mRNA expression can be modulated by the La autoantigen. Brenet, F., Dussault, N., Borch, J., Ferracci, G., Delfino, C., Roepstorff, P., Miquelis, R., Ouafik, L. Mol. Cell. Biol. (2005) [Pubmed]
  27. Human La is found at RNA polymerase III-transcribed genes in vivo. Fairley, J.A., Kantidakis, T., Kenneth, N.S., Intine, R.V., Maraia, R.J., White, R.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  28. The SS-A/SS-B autoantigenic complex: localization and assembly. Peek, R., van Venrooij, W.J., Simons, F., Pruijn, G. Clinical and experimental rheumatology. (1994) [Pubmed]
  29. Anatomical distribution of somatostatin receptors in the brainstem of the human fetus. Carpentier, V., Vaudry, H., Mallet, E., Laquerrière, A., Tayot, J., Leroux, P. Neuroscience (1996) [Pubmed]
  30. Multiple functions of human single-stranded-DNA binding protein in simian virus 40 DNA replication: single-strand stabilization and stimulation of DNA polymerases alpha and delta. Kenny, M.K., Lee, S.H., Hurwitz, J. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  31. Single-stranded-DNA-binding protein-dependent DNA unwinding of the yeast ARS1 region. Matsumoto, K., Ishimi, Y. Mol. Cell. Biol. (1994) [Pubmed]
  32. Role of La autoantigen and polypyrimidine tract-binding protein in HCV replication. Domitrovich, A.M., Diebel, K.W., Ali, N., Sarker, S., Siddiqui, A. Virology (2005) [Pubmed]
  33. Complete congenital heart block is associated with increased autoantibody titers against calreticulin. Orth, T., Dorner, T., Meyer Zum Buschenfelde, K.H., Mayet, W.J. Eur. J. Clin. Invest. (1996) [Pubmed]
  34. Analysis of human sera that are polyreactive in an addressable laser bead immunoassay. Fritzler, M.J., Behmanesh, F., Fritzler, M.L. Clin. Immunol. (2006) [Pubmed]
  35. Induction of antibodies reactive with SSA/Ro-SSB/La and development of congenital heart block in a murine model. Miranda-Carús, M.E., Boutjdir, M., Tseng, C.E., DiDonato, F., Chan, E.K., Buyon, J.P. J. Immunol. (1998) [Pubmed]
  36. Anti-SSA/Ro and anti-SSB/La autoantibodies bind the surface of apoptotic fetal cardiocytes and promote secretion of TNF-alpha by macrophages. Miranda-Carús, M.E., Askanase, A.D., Clancy, R.M., Di Donato, F., Chou, T.M., Libera, M.R., Chan, E.K., Buyon, J.P. J. Immunol. (2000) [Pubmed]
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