Disease relevance of Cochlear Aqueduct

• The authors present the first well-documented case of a patient with persistent bilateral low-frequency sensorineural hearing loss after shunt placement for hydrocephalus and discuss the possible pathophysiological mechanisms including the role of the cochlear aqueduct [1].

High impact information on Cochlear Aqueduct

• One child with profound sensorineural hearing loss had severe bilateral temporal bone dysplasia with a small cochlea lacking an interscalar septum, an abnormal vestibule, and a large cochlear aqueduct [2].
• CSF and peri-lymph communicate through the cochlear aqueduct, permitting increases in CSF pressure to result in increased pressure on the stapes footplate [3].
• Occasionally adjunct modalities (endolymphatic shunt, labyrinthectomy, blocking a cochlear aqueduct, and streptomycin ablation) were used for symptom control [4].
• The cochlear aqueduct in the coronal plane appears as a funnel-shaped configuration with its widest portion opening into the subarachnoid space [5].
• The conversion of LTC4 into LTD4 and LTE4 was lower in perilymph as compared to the cerebrospinal fluid, suggesting a rate limiting function of the cochlear aqueduct that can be defined as a cerebrospinal fluid-labyrinth barrier [6].

Anatomical context of Cochlear Aqueduct

• The profuse flow of CSF was believed to be secondary to a wide-open cochlear aqueduct in the first case, and to an abnormal communication between the internal auditory meatus and the vestibule in the second case [7].
• There was a constellation of bony and membranous defects involving the oval and round windows, cochlear ducts, cochlear aqueducts, endolymphatic ducts and sacs, and vestibular labyrinths [8].

Associations of Cochlear Aqueduct with chemical compounds

• In 24 animals the cochlear aqueduct was blocked on one side, and after 1 to 21 days, kanamycin (300 mg/kg) was given daily and subcutaneously until the pinna reflex began to decrease [9].

References