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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Perilymph


High impact information on Perilymph


Chemical compound and disease context of Perilymph


Biological context of Perilymph


Anatomical context of Perilymph


Associations of Perilymph with chemical compounds


Gene context of Perilymph

  • Taken together, the data suggest that the Ad.IL-1ra-infected cochlear cells synthesized the transgenic human IL-1ra protein, which was then secreted by the cells into the perilymph, resulting in an accelerated neuronal degeneration in hair cell-depleted ears [26].
  • These results suggest that GLAST plays an important role in keeping the concentration of glutamate in the perilymph at a nontoxic level during acoustic overstimulation [27].
  • BDNF or artificial perilymph (AP) was delivered continuously for 28 days [28].
  • The perilymph contains antibody, presumably derived from the systemic circulation and CSF, which would allow for neutralization and help with opsonization and complement fixation [29].
  • An attempt was made to use beta 2-transferrin, as well as apo D and apo J (NA1/NA2), as markers for the diagnosis of perilymph fistula, one of the most controversial and challenging problems for the otologist today [30].

Analytical, diagnostic and therapeutic context of Perilymph


  1. Effects of nitric oxide on normal and ischemic cochlea of the guinea pig. Ruan, R.S., Leong, S.K., Yeoh, K.H. Exp. Neurol. (2001) [Pubmed]
  2. Hypothermia reduces glutamate efflux in perilymph following transient cochlear ischemia. Hyodo, J., Hakuba, N., Koga, K., Watanabe, F., Shudou, M., Taniguchi, M., Gyo, K. Neuroreport (2001) [Pubmed]
  3. Magnetic resonance imaging of perilymphatic fistula. Morris, M.S., Kil, J., Carvlin, M.J. Laryngoscope (1993) [Pubmed]
  4. Perfusion of the inner ear with streptomycin. Shea, J.J. The American journal of otology. (1989) [Pubmed]
  5. Exploratory tympanotomy revisited. Paparella, M.M., Koutroupas, S. Laryngoscope (1982) [Pubmed]
  6. Evidence that amikacin ototoxicity is related to total perilymph area under the concentration-time curve regardless of concentration. Beaubien, A.R., Ormsby, E., Bayne, A., Carrier, K., Crossfield, G., Downes, M., Henri, R., Hodgen, M. Antimicrob. Agents Chemother. (1991) [Pubmed]
  7. Comparative uptake of gentamicin, netilmicin, and amikacin in the guinea pig cochlea and vestibule. Dulon, D., Aran, J.M., Zajic, G., Schacht, J. Antimicrob. Agents Chemother. (1986) [Pubmed]
  8. Effect of pentobarbital anesthesia on amikacin concentrations in plasma and perilymph and evaluation of multiple sampling in perilymph of guinea pigs. Desjardins-Giasson, S., Beaubien, A.R., Cauchy, M.J. Antimicrob. Agents Chemother. (1985) [Pubmed]
  9. Efferent modulation of hair cell tuning in the cochlea of the turtle. Art, J.J., Crawford, A.C., Fettiplace, R., Fuchs, P.A. J. Physiol. (Lond.) (1985) [Pubmed]
  10. Hearing loss and glutamate efflux in the perilymph following transient hindbrain ischemia in gerbils. Hakuba, N., Koga, K., Shudou, M., Watanabe, F., Mitani, A., Gyo, K. J. Comp. Neurol. (2000) [Pubmed]
  11. Recombinant human erythropoietin prevents ischemia-induced apoptosis and necrosis in explant cultures of the rat organ of Corti. Andreeva, N., Nyamaa, A., Haupt, H., Gross, J., Mazurek, B. Neurosci. Lett. (2006) [Pubmed]
  12. Possible roles of nitric oxide in the physiology and pathophysiology of the mammalian cochlea. Ruan, R.S. Ann. N. Y. Acad. Sci. (2002) [Pubmed]
  13. The pharmacokinetics of azlocillin in the perilymph of guinea pigs and otitis media. Federspil, P. Infection (1982) [Pubmed]
  14. Biochemical mechanisms affecting susceptibility to noise-induced hearing loss. Günther, T., Ising, H., Joachims, Z. The American journal of otology. (1989) [Pubmed]
  15. Pharmacokinetics of gentamicin in perilymph and endolymph of the rat as determined by radioimmunoassay. Tran Ba Huy, P., Manuel, C., Meulemans, A., Sterkers, O., Amiel, C. J. Infect. Dis. (1981) [Pubmed]
  16. Mechanism of electrical stimulation-induced neuroprotection: effects of verapamil on protection of primary auditory afferents. Miller, A.L., Prieskorn, D.M., Altschuler, R.A., Miller, J.M. Brain Res. (2003) [Pubmed]
  17. Electrophysiological evidence for the presence of NMDA receptors in the guinea pig cochlea. Puel, J.L., Ladrech, S., Chabert, R., Pujol, R., Eybalin, M. Hear. Res. (1991) [Pubmed]
  18. Osteoprotegerin in the inner ear may inhibit bone remodeling in the otic capsule. Zehnder, A.F., Kristiansen, A.G., Adams, J.C., Merchant, S.N., McKenna, M.J. Laryngoscope (2005) [Pubmed]
  19. Effect of sound stimulation at several levels on concentrations of primary amines, including neurotransmitter candidates, in perilymph of the guinea pig inner ear. Drescher, M.J., Drescher, D.G., Medina, J.E. J. Neurochem. (1983) [Pubmed]
  20. Pharmacokinetics of caroverine in the inner ear and its effects on cochlear function after systemic and local administrations in Guinea pigs. Chen, Z., Duan, M., Lee, H., Ruan, R., Ulfendahl, M. Audiol. Neurootol. (2003) [Pubmed]
  21. Neurotrophins can enhance spiral ganglion cell survival after inner hair cell loss. Miller, J.M., Chi, D.H., O'Keeffe, L.J., Kruszka, P., Raphael, Y., Altschuler, R.A. Int. J. Dev. Neurosci. (1997) [Pubmed]
  22. Toluene disrupts outer hair cell morphometry and intracellular calcium homeostasis in cochlear cells of guinea pigs. Liu, Y., Fechter, L.D. Toxicol. Appl. Pharmacol. (1997) [Pubmed]
  23. Kainic acid selectively alters auditory dendrites connected with cochlear inner hair cells. Pujol, R., Lenoir, M., Robertson, D., Eybalin, M., Johnstone, B.M. Hear. Res. (1985) [Pubmed]
  24. Pharmacokinetics and ototoxicity of gentamicin, tobramycin, and amikacin. Federspil, P., Schätzle, W., Tiesler, E. J. Infect. Dis. (1976) [Pubmed]
  25. Ionic mechanism of the efferent olivo-cochlear inhibition studied by cochlear perfusion in the cat. Desmedt, J.E., Robertson, D. J. Physiol. (Lond.) (1975) [Pubmed]
  26. The influence of interleukin-1 receptor antagonist transgene on spiral ganglion neurons. Komeda, M., Roessler, B.J., Raphael, Y. Hear. Res. (1999) [Pubmed]
  27. Exacerbation of noise-induced hearing loss in mice lacking the glutamate transporter GLAST. Hakuba, N., Koga, K., Gyo, K., Usami, S.I., Tanaka, K. J. Neurosci. (2000) [Pubmed]
  28. Chronic depolarization enhances the trophic effects of brain-derived neurotrophic factor in rescuing auditory neurons following a sensorineural hearing loss. Shepherd, R.K., Coco, A., Epp, S.B., Crook, J.M. J. Comp. Neurol. (2005) [Pubmed]
  29. Immunopathology of the inner ear: an update. Harris, J.P., Heydt, J., Keithley, E.M., Chen, M.C. Ann. N. Y. Acad. Sci. (1997) [Pubmed]
  30. Protein profile of human perilymph: in search of markers for the diagnosis of perilymph fistula and other inner ear disease. Thalmann, I., Kohut, R.I., Ryu, J., Comegys, T.H., Senarita, M., Thalmann, R. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (1994) [Pubmed]
  31. Correlation of amikacin concentrations in perilymph and plasma of continuously infused guinea pigs. Desjardins-Giasson, S., Beaubien, A.R. Antimicrob. Agents Chemother. (1984) [Pubmed]
  32. Analysis of aminoglycoside antibiotics as benzoyl derivatives by high-performance liquid chromatography and its application to the quantitation of neomycin in the perilymph. Harada, T., Iwamori, M., Nagai, Y., Nomura, Y. J. Chromatogr. (1985) [Pubmed]
  33. Cortisol levels in the human perilymph after intravenous administration of prednisolone. Niedermeyer, H.P., Zahneisen, G., Luppa, P., Busch, R., Arnold, W. Audiol. Neurootol. (2003) [Pubmed]
  34. Prostaglandin synthesis by the cochlea of the guinea pig. Influence of aspirin, gentamicin, and acoustic stimulation. Escoubet, B., Amsallem, P., Ferrary, E., Tran Ba Huy, P. Prostaglandins (1985) [Pubmed]
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