The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Round Window

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Round Window


High impact information on Round Window


Chemical compound and disease context of Round Window


Biological context of Round Window


Anatomical context of Round Window


Associations of Round Window with chemical compounds

  • Local administration of caroverine on the round window membrane (RWM) could be a more effective means of administration to avoid systemic side/adverse effects [26].
  • Prostaglandin E(1) was topically applied to the round window membrane of the right ear and changes in cochlear blood flow were calculated [27].
  • Using a 4.7 T MRI scanner, high contrast images of all four cochlear turns were obtained 3.5 h after placing gadolinium on the round window membrane [28].
  • Novel drug release microimplants (0.8 x 1.14 mm; custom-made by Leiras, now Schering OY, Finland) of slow- and fast-release types containing either 0.9 mg beclomethasone or no drug at all were placed unilaterally onto the round-window membrane (RWM) of 45 guinea pigs for a maximum duration of 28 days [29].
  • OBJECTIVE/HYPOTHESIS: Using a novel human labyrinthine sampling model, in vivo gentamicin absorption through the round window can be measured [30].

Gene context of Round Window

  • After appropriate anesthesia, female Lewis rats were injected with ANP via the round window [31].
  • METHODS: After surgical exposure, the round window of female Lewis rats was injected with various concentrations of ANP, ANP plus anti-ANP antibody, or control [32].
  • Samples of fluid were collected from the oval and round windows and were tested for beta-2 transferrin [33].
  • In this study R-phenylisopropyladenosine (R-PIA), a stable non-hydrolyzable adenosine analogue which has been found effective in upregulating antioxidant enzyme activity levels, was topologically applied to the round window of the right ears of chinchillas [34].
  • The round window membrane following application of staphylococcal exotoxin: an electron microscopic study [35].

Analytical, diagnostic and therapeutic context of Round Window


  1. Two emerging perilymph fistula "syndromes" in children. Petroff, M.A., Simmons, F.B., Winzelberg, J. Laryngoscope (1986) [Pubmed]
  2. Microscopic characteristics of round window problems in otology. Choo, Y.B. Laryngoscope (1984) [Pubmed]
  3. Hearing results of intratympanic steroid treatment of endolymphatic hydrops. Arriaga, M.A., Goldman, S. Laryngoscope (1998) [Pubmed]
  4. Role of mannitol in reducing postischemic changes in distortion-product otoacoustic emissions (DPOAEs): a rabbit model. Morawski, K., Telischi, F.F., Merchant, F., Abiy, L.W., Lisowska, G., Namyslowski, G. Laryngoscope (2003) [Pubmed]
  5. Structural changes in the round window membrane following exposure to Escherichia coli lipopolysaccharide and hydrocortisone. Spandow, O., Hellström, S., Anniko, M. Laryngoscope (1990) [Pubmed]
  6. Severe sensorineural deafness in children due to perforation of the round-window membrane. Knight, N.J. Lancet (1977) [Pubmed]
  7. Efferent-mediated protection of the cochlear base from acoustic overexposure by low doses of lithium. Horner, K.C., Higueret, D., Cazals, Y. Eur. J. Neurosci. (1998) [Pubmed]
  8. Effects of vestibular stimulation on acetylcholine release from rat hippocampus: an in vivo microdialysis study. Horii, A., Takeda, N., Mochizuki, T., Okakura-Mochizuki, K., Yamamoto, Y., Yamatodani, A. J. Neurophysiol. (1994) [Pubmed]
  9. Impairment in cochlear function produced by chloramphenicol and noise. Henley, C.M., Brown, R.D., Penny, J.E., Kupetz, S.A., Hodges, K.B., Jobe, P.C. Neuropharmacology (1984) [Pubmed]
  10. Reversible and controlled peripheral vestibular loss by continuous infusion of ropivacaine (Narop((R))) into the round window niche of rats. Magnusson, A.K., Tham, R. Neurosci. Lett. (2006) [Pubmed]
  11. Topical gentamicin and ethacrynic acid: effects on cochlear function. Conlon, B.J., McSwain, S.D., Smith, D.W. Laryngoscope (1998) [Pubmed]
  12. Effect of corticosteroid treatment on salicylate ototoxicity. Park, Y.S., Jung, T.T., Choi, D.J., Rhee, C.K. The Annals of otology, rhinology, and laryngology. (1994) [Pubmed]
  13. Ciprofloxacin and the inner ear--a morphological and round window membrane permeability study. Bagger-Sjöbäck, D., Lundman, L., Nilsson-Ehle, I. ORL J. Otorhinolaryngol. Relat. Spec. (1992) [Pubmed]
  14. Steroid perfusion of the inner ear for sudden sensorineural hearing loss after failure of conventional therapy: a pilot study. Lefebvre, P.P., Staecker, H. Acta Otolaryngol. (2002) [Pubmed]
  15. Quinine affects the response properties of compound action potentials elicited by periodic click trains. Ochi, K., Ohashi, T., Kinoshita, H., Kenmochi, M., Kikuchi, H., Nishino, H. The Annals of otology, rhinology, and laryngology. (2002) [Pubmed]
  16. Gentamicin pharmacokinetics in the chicken inner ear. Bunting, E.C., Park, D.L., Durham, D., Girod, D.A. J. Assoc. Res. Otolaryngol. (2004) [Pubmed]
  17. Expression and function of adenosine receptors in the chinchilla cochlea. Ford, M.S., Maggirwar, S.B., Rybak, L.P., Whitworth, C., Ramkumar, V. Hear. Res. (1997) [Pubmed]
  18. Studies of inner ear blood flow in animals and human beings. Miller, J.M., Ren, T.Y., Nuttall, A.L. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (1995) [Pubmed]
  19. Analysis of gentamicin kinetics in fluids of the inner ear with round window administration. Plontke, S.K., Wood, A.W., Salt, A.N. Otol. Neurotol. (2002) [Pubmed]
  20. Compound action potential input-output decruitment. Effect of topically applied antiseptics. Morizono, T., Sikora, M.A. Archives of otolaryngology (Chicago, Ill. : 1960) (1983) [Pubmed]
  21. Elevation of reactive oxygen species following ischemia-reperfusion in mouse cochlea observed in vivo. Ohlemiller, K.K., Dugan, L.L. Audiol. Neurootol. (1999) [Pubmed]
  22. Experimental studies on round window structure: function and permeability. Goycoolea, M.V., Muchow, D., Schachern, P. Laryngoscope (1988) [Pubmed]
  23. Intratympanic ciprofloxacin and the human labyrinthine sampling model. Becvarovski, Z., Kartush, J.M., Bojrab, D.I. Laryngoscope (2002) [Pubmed]
  24. Hair cell regeneration after local application of gentamicin at the round window of the cochlea in the pigeon. Müller, M., Smolders, J.W. Hear. Res. (1998) [Pubmed]
  25. Cochlear microdialysis for quantification of dexamethasone and fluorescein entry into scala tympani during round window administration. Hahn, H., Kammerer, B., DiMauro, A., Salt, A.N., Plontke, S.K. Hear. Res. (2006) [Pubmed]
  26. Pharmacokinetics of caroverine in the inner ear and its effects on cochlear function after systemic and local administrations in Guinea pigs. Chen, Z., Duan, M., Lee, H., Ruan, R., Ulfendahl, M. Audiol. Neurootol. (2003) [Pubmed]
  27. A comparative study of intratympanic steroid and NO synthase inhibitor for treatment of cochlear lateral wall damage due to acute otitis media. Sone, M., Hayashi, H., Yamamoto, H., Tominaga, M., Nakashima, T. Eur. J. Pharmacol. (2003) [Pubmed]
  28. Imaging of the guinea pig cochlea following round window gadolinium application. Duan, M., Bjelke, B., Fridberger, A., Counter, S.A., Klason, T., Skjönsberg, A., Herrlin, P., Borg, E., Laurell, G. Neuroreport (2004) [Pubmed]
  29. Novel slow- and fast-type drug release round-window microimplants for local drug application to the cochlea: an experimental study in guinea pigs. Arnold, W., Senn, P., Hennig, M., Michaelis, C., Deingruber, K., Scheler, R., Steinhoff, H.J., Riphagen, F., Lamm, K. Audiol. Neurootol. (2005) [Pubmed]
  30. Round window gentamicin absorption: an in vivo human model. Becvarovski, Z., Bojrab, D.I., Michaelides, E.M., Kartush, J.M., Zappia, J.J., LaRouere, M.J. Laryngoscope (2002) [Pubmed]
  31. Atrial natriuretic peptide receptor upregulation in the rat inner ear. Dornhoffer, J.L., Danner, C., Zhou, L., Li, S. The Annals of otology, rhinology, and laryngology. (2002) [Pubmed]
  32. Modification of atrial natriuretic peptide receptor expression in the rat inner ear. Boone, R.T., Zuo, C., Fan, C.Y., Dornhoffer, J. Otol. Neurotol. (2005) [Pubmed]
  33. Correlation of beta-2 transferrin and middle ear abnormalities in congenital perilymphatic fistula. Weber, P.C., Bluestone, C.D., Kenna, M.A., Kelley, R.H. The American journal of otology. (1995) [Pubmed]
  34. R-phenylisopropyladenosine attenuates noise-induced hearing loss in the chinchilla. Hu, B.H., Zheng, X.Y., McFadden, S.L., Kopke, R.D., Henderson, D. Hear. Res. (1997) [Pubmed]
  35. The round window membrane following application of staphylococcal exotoxin: an electron microscopic study. Schachern, P.A., Paparella, M.M., Goycoolea, M., Goldberg, B., Schlievert, P. Laryngoscope (1981) [Pubmed]
  36. Round window administration of gentamicin: a new method for the study of ototoxicity of cochlear hair cells. Husmann, K.R., Morgan, A.S., Girod, D.A., Durham, D. Hear. Res. (1998) [Pubmed]
  37. Novel strategy for treatment of inner ears using a biodegradable gel. Endo, T., Nakagawa, T., Kita, T., Iguchi, F., Kim, T.S., Tamura, T., Iwai, K., Tabata, Y., Ito, J. Laryngoscope (2005) [Pubmed]
  38. Cochleotoxicity of otic drops in the chinchilla: comparative study of Bestron and Cortisporin. Ikeda, K., Morizono, T., Juhn, S.K. The American journal of otology. (1991) [Pubmed]
  39. Effect of leukotriene inhibitor on otoacoustic emissions in salicylate ototoxicity. Arruda, J., Jung, T.T., McGann, D.G. The American journal of otology. (1996) [Pubmed]
  40. Drug delivery to the cochlea using PLGA nanoparticles. Tamura, T., Kita, T., Nakagawa, T., Endo, T., Kim, T.S., Ishihara, T., Mizushima, Y., Higaki, M., Ito, J. Laryngoscope (2005) [Pubmed]
WikiGenes - Universities