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MeSH Review

La Crosse Virus

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Disease relevance of La Crosse Virus


High impact information on La Crosse Virus

  • A membrane glycoprotein that accumulates intracellularly: cellular processing of the large glycoprotein of LaCrosse virus [5].
  • La Crosse virus nonstructural protein NSs counteracts the effects of short interfering RNA [6].
  • These results indicate that (i) the G1 protein by itself can induce an immune response sufficient for protection from a lethal challenge with La Crosse virus, (ii) a neutralizing humoral response correlates with protection, and (iii) the context in which G1 is presented affects its immunogenicity [7].
  • Pretreatment of the cultures with actinomycin D does not affect the ability of La Crosse virus infection to induce mRNA instability, and examination of the rRNAs shows no evidence of specific degradation due to activation of the interferon-associated latent RNase [8].
  • Mechanism of La Crosse virus inhibition by ribavirin [9].

Chemical compound and disease context of La Crosse Virus


Biological context of La Crosse Virus


Anatomical context of La Crosse Virus


Gene context of La Crosse Virus

  • The G2 envelope glycoprotein of La Crosse virus (LAC) was proposed by Ludwig et al. to be a determinant for virus attachment to mosquito midgut cells [16].
  • Surveillance of container-inhabiting mosquitoes was conducted from June 17 through November 9, 1998, at 2 1997 La Crosse virus (LAC) human case sites (Knox and Cocke counties, Tennessee) [17].

Analytical, diagnostic and therapeutic context of La Crosse Virus


  1. Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes. Kochs, G., Janzen, C., Hohenberg, H., Haller, O. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. An avirulent G1 glycoprotein variant of La Crosse bunyavirus with defective fusion function. Gonzalez-Scarano, F., Janssen, R.S., Najjar, J.A., Pobjecky, N., Nathanson, N. J. Virol. (1985) [Pubmed]
  3. The large viral RNA segment of California serogroup bunyaviruses encodes the large viral protein. Endres, M.J., Jacoby, D.R., Janssen, R.S., Gonzalez-Scarano, F., Nathanson, N. J. Gen. Virol. (1989) [Pubmed]
  4. Murine leukemia virus pseudotypes of La Crosse and Hantaan Bunyaviruses: a system for analysis of cell tropism. Ma, M., Kersten, D.B., Kamrud, K.I., Wool-Lewis, R.J., Schmaljohn, C., González-Scarano, F. Virus Res. (1999) [Pubmed]
  5. A membrane glycoprotein that accumulates intracellularly: cellular processing of the large glycoprotein of LaCrosse virus. Madoff, D.H., Lenard, J. Cell (1982) [Pubmed]
  6. La Crosse virus nonstructural protein NSs counteracts the effects of short interfering RNA. Soldan, S.S., Plassmeyer, M.L., Matukonis, M.K., González-Scarano, F. J. Virol. (2005) [Pubmed]
  7. Protection from La Crosse virus encephalitis with recombinant glycoproteins: role of neutralizing anti-G1 antibodies. Pekosz, A., Griot, C., Stillmock, K., Nathanson, N., Gonzalez-Scarano, F. J. Virol. (1995) [Pubmed]
  8. La Crosse virus infection of mammalian cells induces mRNA instability. Raju, R., Kolakofsky, D. J. Virol. (1988) [Pubmed]
  9. Mechanism of La Crosse virus inhibition by ribavirin. Cassidy, L.F., Patterson, J.L. Antimicrob. Agents Chemother. (1989) [Pubmed]
  10. Inhibition of La Crosse virus replication by monensin, monovalent ionophore. Cash, P. J. Gen. Virol. (1982) [Pubmed]
  11. Production of hemagglutinating of La Crosse virus by polyethylene glycol precipitation. Rabson, M., Beaty, B.J., Hildreth, S.W., Shope, R.E. J. Clin. Microbiol. (1981) [Pubmed]
  12. LaCrosse virus gene expression in mammalian and mosquito cells. Rossier, C., Raju, R., Kolakofsky, D. Virology (1988) [Pubmed]
  13. Enhanced neutralization of La Crosse virus by the binding of specific pairs of monoclonal antibodies to the G1 glycoprotein. Kingsford, L. Virology (1984) [Pubmed]
  14. Evidence for three separate antigenic sites on the G1 protein of La Crosse Virus. Grady, L.J., Sanders, M.L., Campbell, W.P. Virology (1983) [Pubmed]
  15. The extracellular domain of La Crosse virus G1 forms oligomers and undergoes pH-dependent conformational changes. Pekosz, A., González-Scarano, F. Virology (1996) [Pubmed]
  16. Identification and localization of conserved antigenic epitopes on the G2 proteins of California serogroup Bunyaviruses. Cheng, L.L., Schultz, K.T., Yuill, T.M., Israel, B.A. Viral Immunol. (2000) [Pubmed]
  17. Temporal abundance, parity, survival rates, and arbovirus isolation of field-collected container-inhabiting mosquitoes in eastern Tennessee. Gottfried, K.L., Gerhardt, R.R., Nasci, R.S., Crabtree, M.B., Karabatsos, N., Burkhalter, K.L., Davis, B.S., Panella, N.A., Paulson, D.J. J. Am. Mosq. Control Assoc. (2002) [Pubmed]
  18. Two monoclonal antibodies against La Crosse virus show host-dependent neutralizing activity. Grady, L.J., Kinch, W. J. Gen. Virol. (1985) [Pubmed]
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