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MeSH Review

Hantaan Virus

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Disease relevance of Hantaan Virus


High impact information on Hantaan Virus


Chemical compound and disease context of Hantaan Virus

  • Analysis of viral polypeptides synthesized in the presence of the drugs suggested differential effects of monensin and tunicamycin on Hantaan virus [11].
  • Hantaan virus replication: effects of monensin, tunicamycin and endoglycosidases on the structural glycoproteins [11].
  • Effect of MDP-Lys(L18), a derivative of MDP, on enhancing host resistance against Hantaan virus infection in newborn mice [12].
  • In this report, utilizing beta3-integrin-transfected CHO cells, we demonstrated that integrin beta3 subunit renders CHO cells susceptible to Chinese Hantaan virus (HTN) strain A9 (isolated in China), and the viral infection was correspondingly inhibited by antibodies to alphavbeta3, alphaIIbbeta3, beta3, and alphav integrins [13].
  • Effect of cordycepin on Hantaan virus 76-118 infection of primary human embryonic pulmonary fibroblasts--characterization of apoptotic effects [14].

Biological context of Hantaan Virus


Anatomical context of Hantaan Virus

  • Viral antigen detected with a monoclonal antibody reacting with nucleocapsid antigen was observed mainly in the cytoplasm of macrophages infected with Hantaan virus, but in the nucleus of cells infected with Seoul virus [19].

Gene context of Hantaan Virus


Analytical, diagnostic and therapeutic context of Hantaan Virus


  1. Pathogenic and nonpathogenic hantaviruses differentially regulate endothelial cell responses. Geimonen, E., Neff, S., Raymond, T., Kocer, S.S., Gavrilovskaya, I.N., Mackow, E.R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Incidence and geographic distribution of serologically verified cases of nephropathia epidemica in Sweden. Settergren, B., Juto, P., Wadell, G., Trollfors, B., Norrby, S.R. Am. J. Epidemiol. (1988) [Pubmed]
  3. In-vivo activity of antivirals against exotic RNA viral infections. Canonico, P.G., Kende, M., Luscri, B.J., Huggins, J.W. J. Antimicrob. Chemother. (1984) [Pubmed]
  4. Baculovirus expression of the small genome segment of Hantaan virus and potential use of the expressed nucleocapsid protein as a diagnostic antigen. Schmaljohn, C.S., Sugiyama, K., Schmaljohn, A.L., Bishop, D.H. J. Gen. Virol. (1988) [Pubmed]
  5. Identification of a cell surface 30 kDa protein as a candidate receptor for Hantaan virus. Kim, T.Y., Choi, Y., Cheong, H.S., Choe, J. J. Gen. Virol. (2002) [Pubmed]
  6. Ribavirin causes error catastrophe during Hantaan virus replication. Severson, W.E., Schmaljohn, C.S., Javadian, A., Jonsson, C.B. J. Virol. (2003) [Pubmed]
  7. Pathogenicity of Hantaan virus in newborn mice: genetic reassortant study demonstrating that a single amino acid change in glycoprotein G1 is related to virulence. Ebihara, H., Yoshimatsu, K., Ogino, M., Araki, K., Ami, Y., Kariwa, H., Takashima, I., Li, D., Arikawa, J. J. Virol. (2000) [Pubmed]
  8. Inhibition of bunyaviruses, phleboviruses, and hantaviruses by human MxA protein. Frese, M., Kochs, G., Feldmann, H., Hertkorn, C., Haller, O. J. Virol. (1996) [Pubmed]
  9. Hemagglutination-inhibiting antibody in hemorrhagic fever with renal syndrome. Tsai, T.F., Tang, Y.W., Hu, S.L., Ye, K.L., Chen, G.L., Xu, Z.Y. J. Infect. Dis. (1984) [Pubmed]
  10. Human and rodent humoral immune responses to Andes virus structural proteins. Tischler, N.D., Galeno, H., Rosemblatt, M., Valenzuela, P.D. Virology (2005) [Pubmed]
  11. Hantaan virus replication: effects of monensin, tunicamycin and endoglycosidases on the structural glycoproteins. Schmaljohn, C.S., Hasty, S.E., Rasmussen, L., Dalrymple, J.M. J. Gen. Virol. (1986) [Pubmed]
  12. Effect of MDP-Lys(L18), a derivative of MDP, on enhancing host resistance against Hantaan virus infection in newborn mice. Yoo, Y.C., Yoshimatsu, K., Hatsuse, R., Tamura, M., Yoshida, R., Tono-oka, S., Arikawa, J., Azuma, I. Vaccine (1995) [Pubmed]
  13. Cellular entry of Hantaan virus A9 strain: specific interactions with beta3 integrins and a novel 70kDa protein. Mou, D.L., Wang, Y.P., Huang, C.X., Li, G.Y., Pan, L., Yang, W.S., Bai, X.F. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  14. Effect of cordycepin on Hantaan virus 76-118 infection of primary human embryonic pulmonary fibroblasts--characterization of apoptotic effects. Xu, F.L., Lee, Y.L., Tsai, W.Y., Lin, S.J., Yang, Z.Q., Yang, C.C., Liu, H.Y., Cheng, L., Xiao, H., Wen, L. Acta Virol. (2005) [Pubmed]
  15. The Hantaan virus glycoprotein precursor is cleaved at the conserved pentapeptide WAASA. Löber, C., Anheier, B., Lindow, S., Klenk, H.D., Feldmann, H. Virology (2001) [Pubmed]
  16. Genetic diversity of hantaviruses associated with hemorrhagic fever with renal syndrome in the far east of Russia. Yashina, L.N., Patrushev, N.A., Ivanov, L.I., Slonova, R.A., Mishin, V.P., Kompanez, G.G., Zdanovskaya, N.I., Kuzina, I.I., Safronov, P.F., Chizhikov, V.E., Schmaljohn, C., Netesov, S.V. Virus Res. (2000) [Pubmed]
  17. Characterization of the mode of Hantaan virus infection in adult mice using a nested reverse transcriptase polymerase chain reaction: transient virus replication in adult mice. Kariwa, H., Kamimura, M., Arikawa, J., Yoshimatsu, K., Takashima, I., Hashimoto, N. Microbiol. Immunol. (1995) [Pubmed]
  18. A dominant antigenic region of the hantaan virus nucleocapsid protein is located within a amino-terminal short stretch of hydrophilic residues. Kang, J.I., Lee, Y.S., Ahn, K., Song, J.W., Song, K.J., Baek, L.J., Lee, P.W., Ahn, B.Y. Virus Genes (2001) [Pubmed]
  19. Cell-mediated immunity to virus causing haemorrhagic fever with renal syndrome: generation of cytotoxic T lymphocytes. Asada, H., Tamura, M., Kondo, K., Dohi, Y., Yamanishi, K. J. Gen. Virol. (1988) [Pubmed]
  20. Effects of human and murine interferons against hemorrhagic fever with renal syndrome (HFRS) virus (Hantaan virus). Tamura, M., Asada, H., Kondo, K., Takahashi, M., Yamanishi, K. Antiviral Res. (1987) [Pubmed]
  21. Characterization of neutralizing monoclonal antibody escape mutants of Hantaan virus 76118. Kikuchi, M., Yoshimatsu, K., Arikawa, J., Yoshida, R., Yoo, Y.C., Isegawa, Y., Yamanishi, K., Tono-oka, S., Azuma, I. Arch. Virol. (1998) [Pubmed]
  22. An etiologic study of hemoglobinuria and blackwater fever in the Kivu Mountains, Zaire. Delacollette, C., Taelman, H., Wery, M. Annales de la Société belge de médecine tropicale. (1995) [Pubmed]
  23. Clinical and epidemiological aspects of hemorrhagic fever with renal syndrome (HFRS) in Greece. Antoniadis, A., Le Duc, J.W., Daniel-Alexiou, S. Eur. J. Epidemiol. (1987) [Pubmed]
  24. The intracellular association of the nucleocapsid protein (NP) of hantaan virus (HTNV) with small ubiquitin-like modifier-1 (SUMO-1) conjugating enzyme 9 (Ubc9). Maeda, A., Lee, B.H., Yoshimatsu, K., Saijo, M., Kurane, I., Arikawa, J., Morikawa, S. Virology (2003) [Pubmed]
  25. Prevalence of hantavirus antibody in patients with chronic renal disease in Egypt. Botros, B.A., Sobh, M., Wierzba, T., Arthur, R.R., Mohareb, E.W., Frenck, R., El Refaie, A., Mahmoud, I., Chapman, G.D., Graham, R.R. Trans. R. Soc. Trop. Med. Hyg. (2004) [Pubmed]
  26. Expression of ICAM-1 on the Hantaan virus-infected human umbilical vein endothelial cells. Song, J.S., Min, C.H., Kang, E., Yu, S.H. Korean J. Intern. Med. (1999) [Pubmed]
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