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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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High impact information on Manubrium

  • Six4/5-Cr is mainly expressed in the manubrium, the feeding, and sex organ [1].
  • The expression of Bmp4, a known downstream target of Msx1 in several developing craniofacial organs, was down-regulated in the malleal primordium, particularly in the region of the developing malleal manubrium, of Msx1 and Msx1(-/-)/Msx2(-/-) embryos [2].
  • MEASUREMENTS AND RESULTS: CXR dimensions were taken at the level of the manubrium sterni (M) and thoracic T7 and T11 levels [3].
  • A transect of bell tissue from the margin to the manubrium revealed a gradient of CA activity, with the highest values at the bell margin and the lowest at the manubrium, despite an even distribution of zooxanthellae [4].
  • The L-glucose treatment did not produce changes in maternal blood D-glucose levels but did produce fetuses with small urinary bladders, microphthalmia and abnormal ossification limited to the manubrium [5].

Anatomical context of Manubrium

  • Portions of the ossicles that are phylogenetically older develop earlier than portions representing more recent evolutionary inventions (manubrium of the malleus, crus longum of the incus) [6].
  • Evaluation of 100 consecutive Tc-99m MDP bone scans revealed in 36 patients a well defined area of increased accumulation of radiotracer at the Angle of Louis--the palpable ridge along the anterior surface of the sternum at the fibrocartilaginous junction of the sternum and manubrium [7].

Associations of Manubrium with chemical compounds

  • The British Steinernema sp. D1 is considered conspecific with S. weiseri n. sp. Males of the new species are mainly characterised by light brown, slightly curved spicules with a long manubrium and the presence of a short tail mucron in the second generation [8].
  • Excursion of pulmonary structures was examined from the upper edge of the manubrium to the top of the diaphragm in three lung zones in the coronal direction [9].
  • Two patients were submitted to partial sternal resection (manubrium); in the first case Marlex mesh alone and in the second a composite graft with Methyl-methacrylate were used [10].

Gene context of Manubrium

  • Anterior decompression and fusion by splitting the manubrium was an effective surgical procedure for OPLL of the upper thoracic spine, to achieve a good outcome, however, the extent of anterior decompression was limited [11].
  • Constant neck flexion by a suture between the skin of the point of the chin and midline of the chest over the manubrium is also widely considered paramount to successful tracheal resections [12].
  • Double-layered manubrium sterni in young children with diastrophic dysplasia [13].


  1. The Sine oculis/Six class family of homeobox genes in jellyfish with and without eyes: development and eye regeneration. Stierwald, M., Yanze, N., Bamert, R.P., Kammermeier, L., Schmid, V. Dev. Biol. (2004) [Pubmed]
  2. Malleal processus brevis is dispensable for normal hearing in mice. Zhang, Z., Zhang, X., Avniel, W.A., Song, Y., Jones, S.M., Jones, T.A., Fermin, C., Chen, Y. Dev. Dyn. (2003) [Pubmed]
  3. Effect of lung volume reduction surgery on bony thorax configuration in severe COPD. Lando, Y., Boiselle, P., Shade, D., Travaline, J.M., Furukawa, S., Criner, G.J. Chest (1999) [Pubmed]
  4. Localization and quantification of carbonic anhydrase activity in the symbiotic Scyphozoan Cassiopea xamachana. Estes, A.M., Kempf, S.C., Henry, R.P. Biol. Bull. (2003) [Pubmed]
  5. Effects of in vivo exposure of pregnant hamsters to glucose. 1. Abnormalities in LVG strain fetuses following intermittent multiple treatments with two isomers. Gale, T.F. Teratology (1991) [Pubmed]
  6. Ontogenetic and phylogenetic transformations of the ear ossicles in marsupial mammals. Sánchez-Villagra, M.R., Gemballa, S., Nummela, S., Smith, K.K., Maier, W. J. Morphol. (2002) [Pubmed]
  7. The Angle of Louis. A potential pitfall ("Louie's Hot Spot") in bone scan interpretation. Fink-Bennett, D.M., Shapiro, E.E. Clinical nuclear medicine. (1984) [Pubmed]
  8. Steinernema weiseri n. sp. (Rhabditida, Steinernematidae), a new entomopathogenic nematode from Europe. Mrácek, Z., Sturhan, D., Reid, A. Syst. Parasitol. (2003) [Pubmed]
  9. Normal pulmonary geometric changes due to respiration: evaluation with inspiratory and expiratory spiral CT. Wang, Q., Takashima, S., Sone, S., Maruyama, Y., Hasegawa, M. Radiation medicine. (1998) [Pubmed]
  10. Synthetic prostheses in repair of chest wall defects after exeresis of malignancies. Tocchi, A., Puma, F., Cerroni, M., Fornasari, V., Daddi, G. International surgery. (1987) [Pubmed]
  11. Anterior decompression and fusion for ossification of the posterior longitudinal ligament of the upper thoracic spine causing myelopathy: using the manubrium splitting approach. Fujimura, Y., Nishi, Y., Nakamura, M., Toyama, Y., Suzuki, N. Spinal Cord (1996) [Pubmed]
  12. An alternative method of neck flexion after tracheal resection. Mueller, D.K., Becker, J., Schell, S.K., Karamchandani, K.M., Munns, J.R., Jaquet, B. Ann. Thorac. Surg. (2004) [Pubmed]
  13. Double-layered manubrium sterni in young children with diastrophic dysplasia. Currarino, G. Pediatric radiology. (2000) [Pubmed]
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