Gene Review:
SIX4 - SIX homeobox 4
Homo sapiens
Synonyms:
AREC3, Homeobox protein SIX4, Sine oculis homeobox homolog 4
- Drosophila homolog of the myotonic dystrophy-associated gene, SIX5, is required for muscle and gonad development. Kirby, R.J., Hamilton, G.M., Finnegan, D.J., Johnson, K.J., Jarman, A.P. Curr. Biol. (2001)
- Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development. Kawakami, K., Ohto, H., Ikeda, K., Roeder, R.G. Nucleic Acids Res. (1996)
- Induction and specification of cranial placodes. Schlosser, G. Dev. Biol. (2006)
- The Sine oculis/Six class family of homeobox genes in jellyfish with and without eyes: development and eye regeneration. Stierwald, M., Yanze, N., Bamert, R.P., Kammermeier, L., Schmid, V. Dev. Biol. (2004)
- Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary anomalies. Gallardo, M.E., Lopez-Rios, J., Fernaud-Espinosa, I., Granadino, B., Sanz, R., Ramos, C., Ayuso, C., Seller, M.J., Brunner, H.G., Bovolenta, P., Rodríguez de Córdoba, S. Genomics (1999)
- Structure and chromosome mapping of the human SIX4 and murine Six4 genes. Ozaki, H., Yamada, K., Kobayashi, M., Asakawa, S., Minoshima, S., Shimizu, N., Kajitani, M., Kawakami, K. Cytogenet. Cell Genet. (1999)
- Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects. Kobayashi, H., Kawakami, K., Asashima, M., Nishinakamura, R. Mech. Dev. (2007)
- Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis. Konishi, Y., Ikeda, K., Iwakura, Y., Kawakami, K. Brain Res. (2006)