Disease relevance of Mucinoses

• Papular mucinosis in L-tryptophan-induced eosinophilia-myalgia syndrome [1].
• Five children (3 with CTS and 1 each with mucolipidosis III and juvenile cutaneous mucinosis) had bilateral disease [2].
• Hodgkin's disease in a patient with follicular and dermal mucinosis and spontaneous ooze of mucin (mucinorrhoea) [3].
• We report the occurrence of scleredema, reticular erythematous mucinosis and lichen myxoedematosus in three different HIV-infected patients, review the literature and discuss the possible relationship between mucin deposits and HIV infection [4].
• Bullous systemic lupus erythematosus with cutaneous mucinosis and leukocytoclastic vasculitis [5].

High impact information on Mucinoses

• Chloroquine induced a myasthenic syndrome in a patient taking the drug for presumable reticular erythematous mucinosis [6].
• Histochemical studies demonstrated that the material is different from the hyaluronic acid-rich substances of the usual forms of cutaneous mucinoses [7].
• A biopsy specimen demonstrated increased dermal mucin with associated plump fibroblasts, consistent with a diagnosis of papular mucinosis [8].
• Reticular erythematous mucinosis syndrome with an infiltration of factor XIIIa+ and hyaluronan synthase 2+ dermal dendrocytes [9].
• Acute periorbital mucinosis in discoid lupus erythematosus [10].

Chemical compound and disease context of Mucinoses

• Circulating immune complexes are increased in both reticular erythematous mucinosis and Jessner's lymphocytic infiltrate of skin and decrease with hydroxychloroquine therapy and clinical clearing [11].
• Tryptophan metabolites have been linked with sclerotic cutaneous diseases but have not been previously implicated in cutaneous mucinoses [1].
• Diclofenac-associated interstitial mucinosis [12].
• Failure of reticular erythematous mucinosis to respond to cyclosporine [13].
• Papular mucinosis associated with AIDS: response to isotretinoin [14].

Anatomical context of Mucinoses

• Histopathology revealed diffuse deposition of mucin throughout the dermis, consistent with papulonodular mucinosis [15].
• A patient with papular mucinosis (scleromyxedema) developed an erosive seronegative rheumatoid-like arthropathy, carpal tunnel syndrome, sicca complex, and marked increase in TG(OKT8) suppressor/cytotoxic circulating T-cells akin to that reported in scleroderma [16].
• The infrequent association of reticular erythematous mucinosis lesions and other forms of cutaneous mucinoses with hypothyroidism is discussed, with special emphasis on the fact that the underlying thyroid disease in all cases was Hashimoto thyroiditis [17].

Gene context of Mucinoses

• Papulonodular dermal mucinosis in systemic lupus erythematosus [18].
• This review discusses the primary mucinoses in which the predominant dermal mucin is hyaluronic acid [19].
• An unusual case of transient papular mucinosis associated with carpal tunnel syndrome [20].
• We report two cases of nervus mucinosis with papulonodules distributed dermatomally on the right T12 and L1 areas [21].
• A case is described of a patient with generalized myxoedema due to Hashimoto thyroiditis involving lesions of reticular erythematous mucinosis and acral papulokeratotic lesions with 'church spire' histological pattern [17].

References