The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Genes, erbB

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Genes, erbB

 

High impact information on Genes, erbB

  • Identification and characterization of the avian erythroblastosis virus erbB gene product as a membrane glycoprotein [4].
  • There are two genes related to the viral erbB gene in the human genome. c-erbB-1 is the same as the gene for the epithelial-growth-factor (EGF) receptor, and c-erbB-2 encodes a receptor-like protein very similar to, but distinct from, the EGF receptor [5].
  • Differences in sequences encoding the carboxyl-terminal domain of the epidermal growth factor receptor correlate with differences in the disease potential of viral erbB genes [6].
  • These results suggest that the erbB gene product enhances inositol phospholipid metabolism and subsequent signal transduction, but that the erbB gene product is not involved directly in lipid kinases, although it is closely associated with lipid kinase [7].
  • In RINm5F cells a spectrum of erbB gene expression was detected (EGF receptor/erbB-1, erbB-2/neu, and erbB-3), whereas INS-1 cells showed only expression of EGF receptor [8].
 

Biological context of Genes, erbB

  • The predicted human erbB-3 gene product is closely related to epidermal growth factor receptor (EGFR) and erbB-2, which have been implicated as oncogenes in model systems and human neoplasia [9].
 

Associations of Genes, erbB with chemical compounds

  • Characterization of site-specific antibodies to the erbB gene product and EGF receptor: inhibition of tyrosine kinase activity [10].
 

Gene context of Genes, erbB

  • IL-6 could not activate the erbB genes [11].
  • Southern blot analysis of transformant DNAs showed that the transforming activity was not due to the acquisition of a ras (Ha, Ki, or N), neu, myc, A-raf, v-raf, erbA, or erbB gene of rat origin [12].
  • Antibodies directed against this region readily identified native and denatured forms of the erbB gene product and EGF receptor as demonstrated by immuneprecipitation and immunoblot analysis [10].

References

  1. Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumors. Yamazaki, H., Fukui, Y., Ueyama, Y., Tamaoki, N., Kawamoto, T., Taniguchi, S., Shibuya, M. Mol. Cell. Biol. (1988) [Pubmed]
  2. Molecular analysis of the erbB gene family calmodulin-binding and calmodulin-like domains in astrocytic gliomas. Arjona, D., Bello, M.J., Alonso, M.E., Gonzalez-Gomez, P., Lomas, J., Aminoso, C., Lopez-Marin, I., Isla, A., De Campos, J.M., Vaquero, J., Gutierrez, M., Villalobo, A., Rey, J.A. Int. J. Oncol. (2004) [Pubmed]
  3. Amplification and differential expression of members of the erbB-gene family in human glioblastoma. Schlegel, J., Stumm, G., Brändle, K., Merdes, A., Mechtersheimer, G., Hynes, N.E., Kiessling, M. J. Neurooncol. (1994) [Pubmed]
  4. Identification and characterization of the avian erythroblastosis virus erbB gene product as a membrane glycoprotein. Hayman, M.J., Ramsay, G.M., Savin, K., Kitchener, G., Graf, T., Beug, H. Cell (1983) [Pubmed]
  5. Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivo. Yokota, J., Yamamoto, T., Toyoshima, K., Terada, M., Sugimura, T., Battifora, H., Cline, M.J. Lancet (1986) [Pubmed]
  6. Differences in sequences encoding the carboxyl-terminal domain of the epidermal growth factor receptor correlate with differences in the disease potential of viral erbB genes. Gamett, D.C., Tracy, S.E., Robinson, H.L. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  7. Altered signal transduction in erbB-transformed cells. Implication of enhanced inositol phospholipid metabolism in erbB-induced transformation. Kato, M., Kawai, S., Takenawa, T. J. Biol. Chem. (1987) [Pubmed]
  8. Growth factor-mediated proliferation and differentiation of insulin-producing INS-1 and RINm5F cells: identification of betacellulin as a novel beta-cell mitogen. Huotari, M.A., Palgi, J., Otonkoski, T. Endocrinology (1998) [Pubmed]
  9. Demonstration of ligand-dependent signaling by the erbB-3 tyrosine kinase and its constitutive activation in human breast tumor cells. Kraus, M.H., Fedi, P., Starks, V., Muraro, R., Aaronson, S.A. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  10. Characterization of site-specific antibodies to the erbB gene product and EGF receptor: inhibition of tyrosine kinase activity. Gentry, L.E., Lawton, A. Virology (1986) [Pubmed]
  11. Role of IL-6 in neuroendocrine differentiation and chemosensitivity of non-small cell lung cancer. Chang, K.T., Huang, C.Y., Tsai, C.M., Chiu, C.H., Lok, Y.Y. Am. J. Physiol. Lung Cell Mol. Physiol. (2005) [Pubmed]
  12. Transforming activity of DNA from rat liver tumors induced by the carcinogen methyl(acetoxymethyl)nitrosamine. Goyette, M., Dolan, M., Kaufmann, W., Kaufman, D., Shank, P.R., Fausto, N. Mol. Carcinog. (1988) [Pubmed]
 
WikiGenes - Universities