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Gene Review

CALML1  -  calmodulin-like 1

Homo sapiens

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Disease relevance of CALML1


High impact information on CALML1


Chemical compound and disease context of CALML1


Biological context of CALML1


Anatomical context of CALML1

  • Proteolysis of inside-out vesicle membranes by trypsin, Pronase, papain, or chymotrypsin produces a calmodulin-like activation of the calcium pump, abolishes its calmodulin sensitivity, and decreases the original 140-kDa EP complex to a limit polypeptide of 80 kDa [17].
  • Human calmodulin-like protein is an epithelial-specific protein regulated during keratinocyte differentiation [18].
  • A calmodulin-like protein has been isolated from scallop striated muscle that activates bovine brain phosphodiesterase to the same extent as does brain calmodulin [19].
  • 3. Amounts of extracellular calmodulin-like activity and immunoreactivity varied during cell growth from low to high density, a peak of extracellular calmodulin preceding DNA synthesis in synchronized K562 cells [20].
  • Evidence that a calmodulin-like calcium-binding domain of the FSH beta-subunit is involved in FSH-induced calcium uptake by Sertoli cells [21].

Associations of CALML1 with chemical compounds


Physical interactions of CALML1


Other interactions of CALML1


Analytical, diagnostic and therapeutic context of CALML1


  1. Characterization of the human calmodulin-like protein expressed in Escherichia coli. Rhyner, J.A., Koller, M., Durussel-Gerber, I., Cox, J.A., Strehler, E.E. Biochemistry (1992) [Pubmed]
  2. Multiple epiphyseal dysplasia and pseudoachondroplasia due to novel mutations in the calmodulin-like repeats of cartilage oligomeric matrix protein. Susic, S., McGrory, J., Ahier, J., Cole, W.G. Clin. Genet. (1997) [Pubmed]
  3. Identification of calmodulin activity in purified retroviruses. Lewis, M.G., Chang, J.Y., Olsen, R.G., Fertel, R.H. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
  4. Molecular analysis of the erbB gene family calmodulin-binding and calmodulin-like domains in astrocytic gliomas. Arjona, D., Bello, M.J., Alonso, M.E., Gonzalez-Gomez, P., Lomas, J., Aminoso, C., Lopez-Marin, I., Isla, A., De Campos, J.M., Vaquero, J., Gutierrez, M., Villalobo, A., Rey, J.A. Int. J. Oncol. (2004) [Pubmed]
  5. Purification and characterization of Bordetella calmodulin-like protein. Nagai, M., Endoh, M., Danbara, H., Nakase, Y. FEMS Microbiol. Lett. (1994) [Pubmed]
  6. Sfi1p has conserved centrin-binding sites and an essential function in budding yeast spindle pole body duplication. Kilmartin, J.V. J. Cell Biol. (2003) [Pubmed]
  7. Calcium-dependent protein kinase isoforms in Petunia have distinct functions in pollen tube growth, including regulating polarity. Yoon, G.M., Dowd, P.E., Gilroy, S., McCubbin, A.G. Plant Cell (2006) [Pubmed]
  8. Diverse mutations in the gene for cartilage oligomeric matrix protein in the pseudoachondroplasia-multiple epiphyseal dysplasia disease spectrum. Briggs, M.D., Mortier, G.R., Cole, W.G., King, L.M., Golik, S.S., Bonaventure, J., Nuytinck, L., De Paepe, A., Leroy, J.G., Biesecker, L., Lipson, M., Wilcox, W.R., Lachman, R.S., Rimoin, D.L., Knowlton, R.G., Cohn, D.H. Am. J. Hum. Genet. (1998) [Pubmed]
  9. A C-terminal, calmodulin-like regulatory domain from the plasma membrane Ca2+-pumping ATPase. Brandt, P., Zurini, M., Neve, R.L., Rhoads, R.E., Vanaman, T.C. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  10. Identification of genes differentially expressed in normal lung and non-small cell lung carcinoma tissue. Schraml, P., Shipman, R., Colombi, M., Ludwig, C.U. Cancer Res. (1994) [Pubmed]
  11. Altered calmodulin activity in buccal epithelial cells from cystic fibrosis patients. McPherson, M.A., Tiligada, E., Bradbury, N.A., Goodchild, M.C. Clin. Chim. Acta (1987) [Pubmed]
  12. Coordinated release of ATP and ACh from cholinergic synaptosomes and its inhibition by calmodulin antagonists. Schweitzer, E. J. Neurosci. (1987) [Pubmed]
  13. Evidence for differing roles for each lobe of the calmodulin-like domain in a calcium-dependent protein kinase. Christodoulou, J., Malmendal, A., Harper, J.F., Chazin, W.J. J. Biol. Chem. (2004) [Pubmed]
  14. Calmodulin-like Protein Increases Filopodia-dependent Cell Motility via Up-regulation of Myosin-10. Bennett, R.D., Mauer, A.S., Strehler, E.E. J. Biol. Chem. (2007) [Pubmed]
  15. The functions of Ca(2+) in bacteria: a role for EF-hand proteins? Michiels, J., Xi, C., Verhaert, J., Vanderleyden, J. Trends Microbiol. (2002) [Pubmed]
  16. Structure of the alpha-actinin-vinculin head domain complex determined by cryo-electron microscopy. Kelly, D.F., Taylor, D.W., Bakolitsa, C., Bobkov, A.A., Bankston, L., Liddington, R.C., Taylor, K.A. J. Mol. Biol. (2006) [Pubmed]
  17. Molecular characterization of the in situ red cell membrane calcium pump by limited proteolysis. Sarkadi, B., Enyedi, A., Földes-Papp, Z., Gárdos, G. J. Biol. Chem. (1986) [Pubmed]
  18. Human calmodulin-like protein is an epithelial-specific protein regulated during keratinocyte differentiation. Rogers, M.S., Kobayashi, T., Pittelkow, M.R., Strehler, E.E. Exp. Cell Res. (2001) [Pubmed]
  19. The stoichiometry and location of troponin I- and troponin C-like proteins in the myofibril of the bay scallop, Aequipecten irradians. Lehman, W., Head, J.F., Grant, P.W. Biochem. J. (1980) [Pubmed]
  20. An extracellular role for calmodulin-like activity in cell proliferation. Crocker, G., Dawson, R.A., Barton, C.H., MacNeil, S. Biochem. J. (1988) [Pubmed]
  21. Evidence that a calmodulin-like calcium-binding domain of the FSH beta-subunit is involved in FSH-induced calcium uptake by Sertoli cells. Grasso, P., Reichert, L.E. J. Mol. Endocrinol. (1994) [Pubmed]
  22. Rice SPK, a calmodulin-like domain protein kinase, is required for storage product accumulation during seed development: phosphorylation of sucrose synthase is a possible factor. Asano, T., Kunieda, N., Omura, Y., Ibe, H., Kawasaki, T., Takano, M., Sato, M., Furuhashi, H., Mujin, T., Takaiwa, F., Wu Cy, C.Y., Tada, Y., Satozawa, T., Sakamoto, M., Shimada, H. Plant Cell (2002) [Pubmed]
  23. Cyclic AMP phosphodiesterase in diabetes. Effect of glyburide. Solomon, S.S., Deaton, J., Shankar, T.P., Palazzolo, M. Diabetes (1986) [Pubmed]
  24. Pseudoachondroplasia due to the substitution of the highly conserved Asp482 by Gly in the seventh calmodulin-like repeat of cartilage oligomeric matrix protein. Susic, S., Ahier, J., Cole, W.G. Hum. Mutat. (1998) [Pubmed]
  25. A survey of calpain inhibitors. Donkor, I.O. Current medicinal chemistry. (2000) [Pubmed]
  26. A minimal serine/threonine protein kinase circadianly regulates phosphoenolpyruvate carboxylase activity in crassulacean acid metabolism-induced leaves of the common ice plant. Taybi, T., Patil, S., Chollet, R., Cushman, J.C. Plant Physiol. (2000) [Pubmed]
  27. Requirement of different subdomains of calpastatin for calpain inhibition and for binding to calmodulin-like domains. Ma, H., Yang, H.Q., Takano, E., Lee, W.J., Hatanaka, M., Maki, M. J. Biochem. (1993) [Pubmed]
  28. Differential responses of S100A2 to oxidative stress and increased intracellular calcium in normal, immortalized, and malignant human keratinocytes. Zhang, T., Woods, T.L., Elder, J.T. J. Invest. Dermatol. (2002) [Pubmed]
  29. The tumor-sensitive calmodulin-like protein is a specific light chain of human unconventional myosin X. Rogers, M.S., Strehler, E.E. J. Biol. Chem. (2001) [Pubmed]
  30. Biochemical characterization of S100A2 in human keratinocytes: subcellular localization, dimerization, and oxidative cross-linking. Deshpande, R., Woods, T.L., Fu, J., Zhang, T., Stoll, S.W., Elder, J.T. J. Invest. Dermatol. (2000) [Pubmed]
  31. Localization of the intronless gene coding for calmodulin-like protein CLP to human chromosome 10p13-ter. Berchtold, M.W., Koller, M., Egli, R., Rhyner, J.A., Hameister, H., Strehler, E.E. Hum. Genet. (1993) [Pubmed]
  32. Thyroid hormone stimulates release of calmodulin-enhancing activity from human erythrocyte membranes in vitro. Lawrence, W.D., Deziel, M.R., Davis, P.J., Schoenl, M., Davis, F.B., Blas, S.D. Clin. Sci. (1993) [Pubmed]
  33. An extracellular calcium-binding domain in bacteria with a distant relationship to EF-hands. Rigden, D.J., Jedrzejas, M.J., Galperin, M.Y. FEMS Microbiol. Lett. (2003) [Pubmed]
  34. Identification of calmodulin-like activity in term human amnion: effect of calmodulin inhibitors on prostaglandin biosynthesis. Olson, D.M., Kramar, D., Smieja, Z. J. Dev. Physiol. (1987) [Pubmed]
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