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Gene Review

EGFR  -  epidermal growth factor receptor

Gallus gallus

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Disease relevance of LOC396494

  • We previously reported that structural rearrangements in the cellular oncogene c-erbB correlate with the development of erythroblastosis induced by avian leukosis virus (ALV). c-erbB recently has been shown to be related to the gene encoding epidermal growth factor receptor [1].
  • Moreover, the proteins expressed in the leukemias are similar to the avian EGF receptor with respect to their phosphopeptide maps, suggesting that they do not carry the C-terminal deletion characteristic of v-erbB [2].
  • Mutations in the epidermal growth factor receptor have been identified in several human tumor types, including gliomas [3].
  • Further, the human c-erb B-1/EGF-r gene in adenocarcinoma of uterine endometrium may be activated by a similar mechanism as that in the chicken v-erb B oncogene [4].
  • A biochemical and morphological investigation of the mechanism of entry of vesicular stomatitis virus (VSV) into host cells of mammalian (HeLa), avian (CER), piscine (EPC) and arthropod (Aedes albopictus) origin, is described [5].

High impact information on LOC396494


Biological context of LOC396494


Anatomical context of LOC396494


Associations of LOC396494 with chemical compounds


Other interactions of LOC396494


Analytical, diagnostic and therapeutic context of LOC396494


  1. c-erbB activation in avian leukosis virus-induced erythroblastosis: clustered integration sites and the arrangement of provirus in the c-erbB alleles. Raines, M.A., Lewis, W.G., Crittenden, L.B., Kung, H.J. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  2. Activation of c-erbB in avian leukosis virus-induced erythroblastosis leads to the expression of a truncated EGF receptor kinase. Lax, I., Kris, R., Sasson, I., Ullrich, A., Hayman, M.J., Beug, H., Schlessinger, J. EMBO J. (1985) [Pubmed]
  3. Activation of Rho is required for ligand-independent oncogenic signaling by a mutant epidermal growth factor receptor. Boerner, J.L., Danielsen, A., McManus, M.J., Maihle, N.J. J. Biol. Chem. (2001) [Pubmed]
  4. Amplification and rearrangement of c-erb B proto-oncogenes in cancer of human female genital tract. Zhang, X., Silva, E., Gershenson, D., Hung, M.C. Oncogene (1989) [Pubmed]
  5. Entry pathway of vesicular stomatitis virus into different host cells. Superti, F., Seganti, L., Ruggeri, F.M., Tinari, A., Donelli, G., Orsi, N. J. Gen. Virol. (1987) [Pubmed]
  6. ARIA: a neuromuscular junction neuregulin. Fischbach, G.D., Rosen, K.M. Annu. Rev. Neurosci. (1997) [Pubmed]
  7. Regulation of Bcl-xL expression in human keratinocytes by cell-substratum adhesion and the epidermal growth factor receptor. Rodeck, U., Jost, M., DuHadaway, J., Kari, C., Jensen, P.J., Risse, B., Ewert, D.L. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  8. Differences in sequences encoding the carboxyl-terminal domain of the epidermal growth factor receptor correlate with differences in the disease potential of viral erbB genes. Gamett, D.C., Tracy, S.E., Robinson, H.L. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  9. An alternatively processed mRNA from the avian c-erbB gene encodes a soluble, truncated form of the receptor that can block ligand-dependent transformation. Flickinger, T.W., Maihle, N.J., Kung, H.J. Mol. Cell. Biol. (1992) [Pubmed]
  10. Studies on epidermal growth factor receptor signaling in vertebrate limb patterning. Omi, M., Fisher, M., Maihle, N.J., Dealy, C.N. Dev. Dyn. (2005) [Pubmed]
  11. Progesterone receptor subunits are high-affinity substrates for phosphorylation by epidermal growth factor receptor. Ghosh-Dastidar, P., Coty, W.A., Griest, R.E., Woo, D.D., Fox, C.F. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  12. Novel nuclear target for thrombin: activation of the Elk1 transcription factor leads to chemokine gene expression. Li, Q.J., Vaingankar, S., Sladek, F.M., Martins-Green, M. Blood (2000) [Pubmed]
  13. The G3 domain of versican enhances cell proliferation via epidermial growth factor-like motifs. Zhang, Y., Cao, L., Yang, B.L., Yang, B.B. J. Biol. Chem. (1998) [Pubmed]
  14. Differentiation of chick lens epithelial cells: involvement of the epidermal growth factor receptor and endogenous ligand. Ireland, M.E., Mrock, L.K. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  15. Immunohistochemical localization of transforming growth factor-alpha and epidermal growth factor-receptor in the mesonephros and metanephros of the chicken. Díaz-Ruiz, C., Pérez-Tomás, R., Culleré, X., Domingo, J. Cell Tissue Res. (1993) [Pubmed]
  16. Immunohistochemical localization of epidermal growth factor receptors, epidermal-growth-factor-like and transforming-growth-factor-alpha-like peptides in chicken ovarian follicles. Onagbesan, O.M., Gullick, W., Woolveridge, I., Peddie, M.J. J. Reprod. Fertil. (1994) [Pubmed]
  17. EGF-induced inhibition of glucose transport is mediated by PKC and MAPK signal pathways in primary cultured chicken hepatocytes. Lee, M.Y., Park, S.H., Lee, Y.J., Heo, J.S., Lee, J.H., Han, H.J. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  18. Expression of the avian c-erb B (EGF receptor) protooncogene during estrogen-promoted oviduct growth. Simmen, F.A. Biochim. Biophys. Acta (1987) [Pubmed]
  19. Expression of epidermal growth factor receptor in chick embryo myocardiocytes: relation with desmin expression during cardiac development. Gámiz, J.M., Melguizo, C., Prados, J., Fernandez, J.E., Alvarez, L., Aránega, A. International journal of cardiology. (1993) [Pubmed]
  20. EGF signaling patterns the feather array by promoting the interbud fate. Atit, R., Conlon, R.A., Niswander, L. Dev. Cell (2003) [Pubmed]
  21. Chicken granulosa cells show differential expression of epidermal growth factor (EGF) and luteinizing hormone (LH) receptor messenger RNA and differential responsiveness to EGF and LH dependent upon location of granulosa cells to the germinal disc. Yao, H.H., Bahr, J.M. Biol. Reprod. (2001) [Pubmed]
  22. Expression and activation of the epidermal growth factor receptor in differentiating cells of the developing and post-hatching chicken lens. Ireland, M.E., Mrock, L.K. Exp. Eye Res. (2004) [Pubmed]
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