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MeSH Review

Encephalitis Virus, Western Equine

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Disease relevance of Encephalitis Virus, Western Equine


High impact information on Encephalitis Virus, Western Equine

  • Two regions of the genome were examined: sequences of 477 nucleotides from the C terminus of the E1 envelope glycoprotein gene which in WEE virus was derived from the Sindbis-like virus parent, and 517 nucleotide sequences at the C terminus of the nsP4 gene which in WEE virus was derived from the EEE-like virus parent [4].
  • The E2 glycoprotein of WEE virus had a pI of 8.4 and induced antibody which was virus specific by neutralization (PRNT) but cross-reacted with HJ virus in the radioimmune precipitation (RIP) test [5].
  • Poly ICLC pretreatment also protects mice against a respiratory challenge of western equine encephalitis (WEE) virus, at a level comparable to inactivated WEE vaccine [6].
  • We evaluated two of these strains (WE2102 and WE2130) for their ability to replicate in and be transmitted by Culex tarsalis, the principal natural vector of WEE virus in the United States. Each of the vaccine candidates contained a deletion of the PE2 furin cleavage site and a secondary mutation in the E1 or E2 glycoprotein [7].
  • Three epizootic WEE virus strains (McMillan, Cba 87, and Cba CIV 180) and five enzootic WEE complex viruses (Highlands J [HJ], Y62-33, Aura, Fort Morgan [FM], and WEE AG80-646) were examined [8].

Chemical compound and disease context of Encephalitis Virus, Western Equine


Biological context of Encephalitis Virus, Western Equine


Anatomical context of Encephalitis Virus, Western Equine


Gene context of Encephalitis Virus, Western Equine


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  3. Evaluation of a Western Equine Encephalitis recombinant E1 protein for protective immunity and diagnostics. Das, D., Gares, S.L., Nagata, L.P., Suresh, M.R. Antiviral Res. (2004) [Pubmed]
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  7. Limited potential for mosquito transmission of genetically engineered, live-attenuated western equine encephalitis virus vaccine candidates. Turell, M.J., O'Guinn, M.L., Parker, M.D. Am. J. Trop. Med. Hyg. (2003) [Pubmed]
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  12. Infection of a poikilothermic cell line (XL-2) with eastern equine encephalitis and western equine encephalitis viruses. Morier, L., Cantelar, N., Soler, M. J. Med. Virol. (1987) [Pubmed]
  13. Pharmacokinetics study of a novel chimeric single-chain variable fragment antibody against western equine encephalitis virus. Long, M.C., Marshall, K.E., Kearney, B.J., Ludwig, G.V., Wong, J.P., Nagata, L.P. Hybridoma (2001) [Pubmed]
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