Disease relevance of Adenoma, Bile Duct

• The incidence of common duct polyps (44%), gallbladder polyps (44%), and cholangiomas (44%) was significantly higher in the BOP-treated F0 generation than in their litters (which had incidences of 10, 0, and 40%, respectively) [1].
• All cholangiomas and cholangiocarcinomas, but no hepatocellular adenomas and carcinomas, overexpressed the p53 protein [2].
• 13C pretreatment inhibited the incidence of cholangiolar tumors (cholangioma 3.6% vs 31.3%, cholangiocarcinoma 3.6% vs 13.0%) and metaplastic pancreatic cells (5.1% vs 19.1%), whereas BNF and PCB had no effect [3].
• RT-PCR assay of mammaglobin B detected 14 of 15 histologically positive lymph nodes from patients with gastric cancer, colon cancer and cholangioma [4].

High impact information on Adenoma, Bile Duct

• SYN, PHO, G6PASE, G6PDH, GAPDH, G3PDH, MDH, ALKPASE and GGT activities were detected in oval cells; cholangiofibrotic lesions, cystic cholangiomas and cholangiofibromas stained strongly for GAPDH, G3PDH and MDH [5].
• After feeding a comparable dose (0.1%) of oxytetracycline and sodium nitrite for 60 weeks, liver tumors were present in 4 of 30 rats (3 hepatocellular tumors and 1 cholangioma) [6].
• A response to carbogen was observed in HCCs but not in cholangiomas [7].
• PCB- exposed and control rats developed simple cholangioma, cystic cholangioma and adenofibrosis; the incidence of each was greater in the PCB group [8].
• In sections of livers from rats exposed to diethylnitrosamine, the MAb 19C6 selectively stained bile duct-like structures in cholangiomas, while other preneoplastic and neoplastic lesions were not stained [9].

Chemical compound and disease context of Adenoma, Bile Duct

• While there was some evidence that ascorbic acid reduced the incidence of cystic cholangioma, the ascorbic acid and methionine treatment groups also contained significantly fewer animals surviving to the 26-month sacrifice [10].

References