Disease relevance of Bisolvomycin

• Oxytetracycline-induced thrombocytopenic purpura [1].
• Triethylene tetramine dihydrochloride toxicity in primary biliary cirrhosis [2].
• Triethylene tetramine dihydrochloride (trien) is a copper chelating agent used as the alternative drug of choice in the treatment of Wilson's disease [2].
• A patient with Whipple's disease is described, and multiparameter flow cytometric examinations of several of the patient's phagocyte functions 3 and 9 mo after the start of oxytetracycline therapy are reported [3].
• Oxytetracycline was given by means of chronic i.v. infusion, in amounts which impair specifically mitochondrial protein synthesis, to Wistar rats carrying a solid Leydig cell tumor [4].

Psychiatry related information on Bisolvomycin

• 1. The effects of various levels of dehydration induced by water deprivation were studied in six Nubian goats on the pharmacokinetics of oxytetracycline after intravenous administration (5 mg/kg) [5].

High impact information on Bisolvomycin

• Treatment of Wilson's disease with trientine (triethylene tetramine) dihydrochloride [6].
• At present immunization against Theileria parva is by infection with live sporozoites and simultaneous treatment with a long-acting oxytetracycline [7].
• Oxytetracycline is administered by means of continuous infusion in such a way that the oxytetracycline concentration in serum and ascitic fluid is maintained at a level at which only mitochondrial protein synthesis is blocked [8].
• Although otcD1 is contiguous with the ketoreductase gene, they are located an unusually large distance from the genes encoding the "minimal polyketide synthase" of the oxytetracycline gene cluster [9].
• Benextramine, a tetramine disulfide, irreversibly inhibits neuropeptide Y (NPY) binding to the 50-kDa Y2 NPY receptor in bovine hippocampus (Li, W., MacDonald, R. G., and Hexum, T. D. (1991) Eur. J. Pharmacol. 207, 89-91) [10].

Chemical compound and disease context of Bisolvomycin

• In lean mice oxytetracycline also significantly reduced body weight and serum glucose, while no effects on obesity or IRI levels were noted [11].
• Dexamethasone and oxytetracycline reverse the potentiation of neurogenic inflammation in airways of rats with Mycoplasma pulmonis infection [12].
• Flow cytometry together with SYBR green I and propidium iodide was used to study the effects of enrofloxacin, ciprofloxacin, gentamicin, chloramphenicol, oxytetracycline, and tylosin on four mycoplasma species [13].
• The effects in mice of oral treatment with amoxicillin, ampicillin, and oxytetracycline against an otherwise lethal intranasal infection with Chlamydia trachomatis (mouse pneumonitis) were studied [14].
• Influence of subtherapeutic levels of a combination of neomycin and oxytetracycline on Salmonella typhimurium in swine, calves, and chickens [15].

Biological context of Bisolvomycin

• The 387kb linear plasmid pPZG101 of Streptomyces rimosus R6 can integrate into the chromosome or form a prime plasmid carrying the oxytetracycline biosynthesis cluster [16].
• The 1 Mb linear plasmid pPZG103 in mutant MV17 had also arisen from a cross-over between pPZG101 and the chromosome, so that one end of pPZG103 consists of c. 850 kb of chromosomal sequence including the oxytetracycline biosynthesis cluster [16].
• The sequence of a 2657 bp DNA fragment containing the coding and regulatory regions of the oxytetracycline (OTC)-resistance gene, otrA, from the OTC producer Streptomyces rimosus was determined [17].
• Isolates of Vibrio harveyi, a prawn pathogen, have demonstrated multiple antibiotic resistance to commonly used antimicrobial agents, such as oxytetracycline [18].
• Structure-activity relationships among di- and tetramine disulfides related to benextramine [19].

Anatomical context of Bisolvomycin

• Oxytetracycline (OTC) treatment was associated with regranulation of the islet cells and increased pancreatic insulin content in the ob/ob mouse [20].
• The results presented also indicated that oxytetracycline treatment led to a decrease in the basal incorporation of lipids into the liver in vivo and the adipose tissue in vivo and in vitro [21].
• Unlike bovine neutrophils treated with penicillin, ceftiofur, oxytetracycline, or dexamethasone, neutrophils exposed to tilmicosin became apoptotic, regardless of the presence or absence of P. haemolytica [22].
• Lack of lysosomal fusion with phagosomes containing Ehrlichia risticii in P388D1 cells: abrogation of inhibition with oxytetracycline [23].
• New Mg2+-dependent oxytetracycline resistance determinant tet 34 in Vibrio isolates from marine fish intestinal contents [24].

Associations of Bisolvomycin with other chemical compounds

• The insulin sensitivity of the peripheral tissues in ob/ob mice treated with oxytetracycline was assessed both in vivo and in vitro by measuring the effect of insulin on the incorporation of glucose into glycogen in diaphragm muscle and on the incorporation of glucose and 3H2O into lipids in epidymal adipose tissue [21].
• Sprague-Dawley rats were given combinations of aminopyrine or oxytetracycline and sodium nitrite in drinking water [25].
• Lysosomes in cells ranging in infectivity from 30 to 70% were labeled cytochemically with acid phosphatase or via endocytosis of thorium dioxide or cationized ferritin to document phagosome-lysosome (P-L) fusion in untreated cells and cells treated with oxytetracycline [23].
• This tetracycline biosensor was used to detect the production of oxytetracycline by S. rimosus introduced into sterile soil [26].
• Regarding oropharyngeal organisms, M. pulmonis was eradicated from only 20 of 42 TO or BALB/c mice with oxytetracycline and from none of 15 mice with lymecycline [27].

Gene context of Bisolvomycin

• We found that deletion of SOD1 (encoding Cu/Zn superoxide dismutase) rendered S. cerevisiae hypersensitive to oxytetracycline (OTC): a sod1Delta mutant exhibited a >95% reduction in colony-forming ability at an OTC concentration of 20 microg ml(-1), whereas concentrations of up to 1,000 microg ml(-1) had no effect on the growth of the wild type [28].
• In addition, oxytetracycline, minocycline and doxycycline inhibited the organic anion uptake by hOAT1, whereas oxytetracycline, minocycline but not doxycycline inhibited the organic anion uptake by hOAT2 [29].
• P-glycoprotein-mediated transport of oxytetracycline in the Caco-2 cell model [30].
• Treatment of neuroblastoma cells with the copper chelator triethylene tetramine tetrahydrochloride induced intracellular decrease of copper content paralleled by diminished activity of the enzymes Cu, Zn superoxide dismutase, and cytochrome c oxidase [31].
• The addition of oxytetracycline 6 h after E. chaffeensis infection caused a decrease in TfR mRNA which returned to the basal level by 24 h postinfection [32].

Analytical, diagnostic and therapeutic context of Bisolvomycin

• The rates of these reactions varied within and between individuals and were inhibited by oxygen and centrifugation but not by oxytetracycline [33].
• The rickettsialpox infection was terminated in euthymic mice with only two intraperitoneal injections of the antibiotic oxytetracycline, whereas prolonged treatment was necessary to terminate the infection in athymic mice [34].
• We started a treatment trial for malignant pericardial tamponade with intracavitary oxytetracycline, 500-1,000 mg/day, administered via an indwelling pericardial cannula after extraction of as much pericardial fluid as possible [35].
• The activity of oxytetracycline and seven macrolide antibiotics was investigated against a prototype strain of Chlamydia pneumoniae in cell culture [36].
• A direct injection analysis by high-performance liquid chromatography has been developed for oxytetracycline in serum of animals and fish [37].

References