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Gene Review

G6pc  -  glucose-6-phosphatase, catalytic subunit

Rattus norvegicus

Synonyms: G-6-Pase, G6Pase, G6pt, Glucose-6-phosphatase
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Disease relevance of G6pc

  • Similar insulin-induced hypoglycemia experiments performed in adrenalectomized rats did not induce any stimulation of G-6-Pase [1].
  • The successful ultracytochemical localization of G-6-Pase in cultured hepatoma cells has not been reported previously [2].
  • In conclusion, 1) BMOV inhibits PEPCK mRNA expression and activity by rapid mechanisms that are not reproduced simply by correction of hyperglycemia; and 2) BMOV inhibits G-6-Pase expression by complex mechanisms that depend, in part, on correction of hyperglycemia [3].
  • Comparison of marker enzymes in cirrhotic livers and in tumors either with or without cirrhosis indicated that changes in cytochrome P450 and G-6-Pase were rather the results of parenchymal damage, while GGT was elevated only in tumorous livers [4].
  • Mixed cell foci and hepatocellular adenomas developed within 22-30 weeks and exhibited a remarkable decrease of G6PASE activity, a strong increase of G6PDH, GAPDH, G3PDH and MDH activities as well as extremely high ALKPASE and GGT activities [5].

High impact information on G6pc


Chemical compound and disease context of G6pc

  • This study was conducted to test the hypothesis of the activation of glucose-6-phosphatase (G-6-Pase) in situations where the liver is supposed to sustain high glucose supply, such as during the counterregulatory response to hypoglycemia [1].
  • Activation of liver G-6-Pase in response to insulin-induced hypoglycemia or epinephrine infusion in the rat [1].

Biological context of G6pc


Anatomical context of G6pc


Associations of G6pc with chemical compounds

  • Infusion of epinephrine (1 microg x kg(-1) x min(-1)) in normal rats induced a dramatic 80% increase in EGP and a 60% increase in G-6-Pase activity [1].
  • 2-Deoxyglucose-6-phosphate (DG-6-P) may therefore have limited access to glucose-6-phosphatase (G-6-Pase), and transport of the DG-6-P across the endoplasmic reticular membrane may be rate limiting to its dephosphorylation [8].
  • A detailed kinetic analysis of G-6-Pase activity has been performed to distinguish between effects on the microsomal carrier for glucose-6-phosphate and those on the enzyme itself [15].
  • These differences could not be explained by changes in the response of isolated microsomes to sodium deoxycholate or by effects on the energy of activation of G-6-Pase [15].
  • Phlorizin corrected plasma glucose but had no effect on PEPCK mRNA and only partially normalized G-6-Pase mRNA [3].

Other interactions of G6pc

  • In these models, morphology, tumor incidence as well as polysubstrate monooxygenase system, gamma-glutamyltransferase (GGT) and glucose-6-phosphatase (G-6-Pase) were studied [4].
  • In the livers of T-1095-treated ZDF rats, hepatic glucose production rate (HGP) and glucose utilization rate (GUR) showed marked recovery, with almost complete normalization of reduced glucokinase/glucose-6-phosphatase (G-6-Pase) activities ratio [16].
  • As pancreatectomized foetuses develop sub-normal liver G-6-Pase activity, glucagon is probably not responsible for the increase in this activity occurring during normal development before birth [17].
  • In addition, diminution or depletion of glycogen, reduction of catalase-containing peroxisomes, increase of G-6-Pase activity, and depletion of cytochrome c oxidase in many mitochondria were also observed in hepatocytes of experimental animals [18].
  • The overall results suggest that LPS stimulates: (a) hepatic synthesis and secretion of fibronectin; (b) uptake of calcium by hepatocytes; and (c) G-6-Pase activity [18].

Analytical, diagnostic and therapeutic context of G6pc


  1. Activation of liver G-6-Pase in response to insulin-induced hypoglycemia or epinephrine infusion in the rat. Bady, I., Zitoun, C., Guignot, L., Mithieux, G. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]
  2. Ultracytochemical localization of glucose-6-phosphatase in Chang rat hepatoma in vivo and in vitro. Moller, P.C., Yokoyama, M., Chang, J.P. J. Natl. Cancer Inst. (1977) [Pubmed]
  3. Mechanisms by which bis(maltolato)oxovanadium(IV) normalizes phosphoenolpyruvate carboxykinase and glucose-6-phosphatase expression in streptozotocin-diabetic rats in vivo. Marzban, L., Rahimian, R., Brownsey, R.W., McNeill, J.H. Endocrinology (2002) [Pubmed]
  4. Modification of DENA-induced hepatocarcinogenesis by CCl4 cirrhosis. Comparison of the marker enzyme patterns. Kovalszky, I., Szeberenyi, S., Zalatnai, A., Vincze, I., Lapis, K., Jeney, A. Carcinogenesis (1992) [Pubmed]
  5. Enzyme histochemical and immunohistochemical characterization of oval and parenchymal cells proliferating in livers of rats fed a choline-deficient/DL-ethionine-supplemented diet. Steinberg, P., Hacker, H.J., Dienes, H.P., Oesch, F., Bannasch, P. Carcinogenesis (1991) [Pubmed]
  6. Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding. Oakes, N.D., Cooney, G.J., Camilleri, S., Chisholm, D.J., Kraegen, E.W. Diabetes (1997) [Pubmed]
  7. Hepatic glucose-6-phosphatase activities and correlated ultrastructural alterations in hepatocytes of diabetic rats. Garfield, S.A., Cardell, R.R. Diabetes (1979) [Pubmed]
  8. Refinement of the kinetic model of the 2-[14C]deoxyglucose method to incorporate effects of intracellular compartmentation in brain. Schmidt, K., Lucignani, G., Mori, K., Jay, T., Palombo, E., Nelson, T., Pettigrew, K., Holden, J.E., Sokoloff, L. J. Cereb. Blood Flow Metab. (1989) [Pubmed]
  9. Diets enriched in sucrose or fat increase gluconeogenesis and G-6-Pase but not basal glucose production in rats. Commerford, S.R., Ferniza, J.B., Bizeau, M.E., Thresher, J.S., Willis, W.T., Pagliassotti, M.J. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]
  10. Hormonal control of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase activities in the fetal rat kidney. Delaval, E., Moreau, E., Geloso, J.P. Pediatr. Res. (1981) [Pubmed]
  11. Carbon tetrachloride-induced loss of microsomal glucose 6-phosphatase and cytochrome P-450 in vitro. Masuda, Y. Jpn. J. Pharmacol. (1981) [Pubmed]
  12. Negligible glucose-6-phosphatase activity in cultured astroglia. Gotoh, J., Itoh, Y., Kuang, T.Y., Cook, M., Law, M.J., Sokoloff, L. J. Neurochem. (2000) [Pubmed]
  13. The protective effects of eugenol on carbon tetrachloride induced hepatotoxicity in rats. Nagababu, E., Sesikeran, B., Lakshmaiah, N. Free Radic. Res. (1995) [Pubmed]
  14. Stable overexpression of the glucose-6-phosphatase catalytic subunit attenuates glucose sensitivity of insulin secretion from a mouse pancreatic beta-cell line. Iizuka, K., Nakajima, H., Ono, A., Okita, K., Miyazaki, J., Miyagawa, J., Namba, M., Hanafusa, T., Matsuzawa, Y. J. Endocrinol. (2000) [Pubmed]
  15. Age-related differences in the response of hepatic microsomal glucose-6-phosphatase to triiodothyronine and triamcinolone in the rat. Dobrosielski-Vergona, K., Widnell, C.C. Endocrinology (1982) [Pubmed]
  16. Hyperglycemia contributes insulin resistance in hepatic and adipose tissue but not skeletal muscle of ZDF rats. Nawano, M., Oku, A., Ueta, K., Umebayashi, I., Ishirahara, T., Arakawa, K., Saito, A., Anai, M., Kikuchi, M., Asano, T. Am. J. Physiol. Endocrinol. Metab. (2000) [Pubmed]
  17. Effects of sub-total gastro-intestinal pancreatectomy of the rat foetus. Félix, J.M., Jacquot, R.L. J. Endocrinol. (1976) [Pubmed]
  18. Cytochemical changes in hepatocytes of rats with endotoxemia or sepsis: localization of fibronectin, calcium, and enzymes. Kang, Y.H., McKenna, T., Watson, L.P., Williams, R., Holt, M. J. Histochem. Cytochem. (1988) [Pubmed]
  19. Effect of lead nitrate on liver carbohydrate enzymes and glycogen content in the rat. Hacker, H.J., Bannasch, P., Columbano, A. Carcinogenesis (1990) [Pubmed]
  20. Induction of control genes in intestinal gluconeogenesis is sequential during fasting and maximal in diabetes. Mithieux, G., Bady, I., Gautier, A., Croset, M., Rajas, F., Zitoun, C. Am. J. Physiol. Endocrinol. Metab. (2004) [Pubmed]
  21. Hepatocellular expression of glucose-6-phosphatase is unaltered during hepatic regeneration. Zakko, W.F., Berg, C.L., Gollan, J.L., Green, R.M. Am. J. Physiol. (1998) [Pubmed]
  22. A histochemical study of the regional distribution in the rat brain of enzymatic activity hydrolyzing glucose- and 2-deoxyglucose-6-phosphate. Pertsch, M., Duncan, G.E., Stumpf, W.E., Pilgrim, C. Histochemistry (1988) [Pubmed]
  23. Isolation and nucleotide sequence of canine glucose-6-phosphatase mRNA: identification of mutation in puppies with glycogen storage disease type Ia. Kishnani, P.S., Bao, Y., Wu, J.Y., Brix, A.E., Lin, J.L., Chen, Y.T. Biochem. Mol. Med. (1997) [Pubmed]
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