Disease relevance of Deltaretrovirus Infections

• The hybrid proteins containing the NH2-terminal (EH9) and COOH-terminal (EA1) halves were both immunologically reactive with sera from adult T-cell leukemia patients, demonstrating the utility of the hybrid proteins for diagnosis of HTLV infection [1].
• CONCLUSION: In the study of a population in which 97 percent of HTLV infections are due to HTLV-I, these data support the three-protein criteria (rgp21, p19, and p24) for a positive blot reading [2].
• Spontaneous proliferation of memory (CD45RO+) and naive (CD45RO-) subsets of CD4 cells and CD8 cells in human T lymphotropic virus (HTLV) infection: distinctive patterns for HTLV-I versus HTLV-II [3].
• Epidemiological aspects of retrovirus (HTLV) infection among Indian populations in the Amazon Region of Brazil [4].

High impact information on Deltaretrovirus Infections

• Furthermore, ectopic expression of GLUT-1, but not the related transporter GLUT-3, restores HTLV infection abrogated by either GLUT-1 siRNAs or interfering HTLV envelope glycoproteins [5].
• The mechanism of abnormal IL-2 receptor expression in HTLV infection is discussed [6].
• These studies are consistent with previous evidence indicative of a high rate of HTLV infection within families, and they show that people whose sera are negative for antibodies may still be infected by HTLV [7].
• The glucose transporter GLUT1, a member of the multimembrane-spanning facilitative nutrient transporter family, serves as a receptor for human T cell leukemia virus (HTLV) infection [8].
• Hematopoietic progenitor cells and thymuses may be targets for HTLV infection in humans, and these events may play a role in the pathogenesis associated with infection [9].

Chemical compound and disease context of Deltaretrovirus Infections

• Since human T lymphotropic virus (HTLV) infection was recently described in Israel and other Middle Eastern countries, we have investigated the presence of HTLV type 1 and type 2 in a group of 299 intravenous (IV) drug abusers who were seen at a large methadone clinic in the Tel Aviv area in 1986-1987 [10].

Biological context of Deltaretrovirus Infections

• Moreover, the HTLV tax-rex and pol DNA sequence have been searched in the peripheral blood mononuclear cells (PBMCs) of 15 ALS patients and 15 HIV-positive HTLV-negative subjects using a nested PCR currently employed in our laboratory for the study of HTLV infections [11].
• In contrast, there was no correlation between BLV-infection status and expression of major histocompatibility complex (Mhc) Class I or Class II genes [12].

Gene context of Deltaretrovirus Infections

• The possible relationship between ADF production, HTLV infection, and the abnormal expression of IL-2-R is suggested, and these abnormalities may be advantageous for the leukemogenesis and abnormal growth of ATL [13].
• In this study, we asked if SLP was restricted to the memory (CD45RO+) cell subset of CD4 and CD8 cells in HTLV infection [3].
• This increased expression of ICAM-1 in response to the Tax protein may play an important role in the lymphoproliferation associated with HTLV infection [14].
• HTLV infection among Italian intravenous drug users and North African subjects detected by the polymerase chain reaction and serological methods [15].
• Results reveal a strong association between MBL polymorphism and HTLV infection [16].

References