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BOLA  -  major histocompatibility complex

Bos taurus

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Disease relevance of BOLA

  • The presence of class I major histocompatibility complex-restricted CTLs with potentially autoreactive specificities in preimmune animals raises the possibility of a role for such cells in autoimmune disease states [1].
  • A major histocompatibility complex class I (BoLA-A) allele that has been previously associated with resistance to PL was associated with longevity and realization of milk production potentials, indicating that genetic resistance to PL will have an economic benefit in herds where BLV is endemic [2].
  • We generated a recombinant influenza virus expressing an epitope from the circumsporozoite protein of P. yoelii known to be recognized by CD8+ T cells and demonstrated that this vector induced class I major histocompatibility complex-restricted cytotoxic T cells against this foreign epitope [3].
  • Using a permeabilized cell system in which major histocompatibility complex class I heavy chains are retrotranslocated under the influence of the human cytomegalovirus protein US11, we demonstrate that polyubiquitination alone is insufficient to provide the driving force for retrotranslocation [4].
  • Since malignant transformation of cells is associated with changes in structures coded by the MHC region, 10 cultured human melanoma and sarcoma cells and autologous SV40-transformed fibroblasts were tested for expression of MRBC receptors and compared with normal autologous fibroblasts [5].

High impact information on BOLA


Chemical compound and disease context of BOLA


Biological context of BOLA

  • A possible explanation for the unique findings that the expression of anti-GPhe idiotypic determinants in mice of H-2q haplotype are dictated by the gene product in the MHC is that the macrophages in mice of H-2q haplotype present unique determinants of GPhe polymer in the response process to GHphe [14].
  • Specific suppression of major histocompatibility complex class I and class II genes in astrocytes by brain-enriched gangliosides [15].
  • Experiments were conducted to determine whether the acquisition of the secondary B cells' MHC collaborative phenotype was dependent on the presence of T cells during in vivo immunization [16].
  • This induction is uniquely mediated by three DNA elements in the promoter region of class II MHC genes [17].
  • These studies may be important for understanding mechanisms of central nervous system (CNS)-specific regulation of major histocompatibility molecules in neuroectodermal cells and the role of gangliosides in regulating MHC-restricted antiviral and autoimmune responses within the CNS [15].

Anatomical context of BOLA


Associations of BOLA with chemical compounds


Regulatory relationships of BOLA


Other interactions of BOLA


Analytical, diagnostic and therapeutic context of BOLA


  1. Identification of an autologous insulin B chain peptide as a target antigen for H-2Kb-restricted cytotoxic T lymphocytes. Sheil, J.M., Shepherd, S.E., Klimo, G.F., Paterson, Y. J. Exp. Med. (1992) [Pubmed]
  2. Milk and fat yields decline in bovine leukemia virus-infected Holstein cattle with persistent lymphocytosis. Da, Y., Shanks, R.D., Stewart, J.A., Lewin, H.A. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  3. Priming with recombinant influenza virus followed by administration of recombinant vaccinia virus induces CD8+ T-cell-mediated protective immunity against malaria. Li, S., Rodrigues, M., Rodriguez, D., Rodriguez, J.R., Esteban, M., Palese, P., Nussenzweig, R.S., Zavala, F. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  4. Polyubiquitin serves as a recognition signal, rather than a ratcheting molecule, during retrotranslocation of proteins across the endoplasmic reticulum membrane. Flierman, D., Ye, Y., Dai, M., Chau, V., Rapoport, T.A. J. Biol. Chem. (2003) [Pubmed]
  5. Appearance of receptors for Macaca speciosa red blood cells on human fibroblasts transformed by simian virus 40. Curry, R.A., Pellegrino, M.A., Saxton, R.E., Jensen, F., Ferrone, S. J. Immunol. (1980) [Pubmed]
  6. HLA-A and B polymorphisms predate the divergence of humans and chimpanzees. Lawlor, D.A., Ward, F.E., Ennis, P.D., Jackson, A.P., Parham, P. Nature (1988) [Pubmed]
  7. Beta 2-microglobulin from serum associates with MHC class I antigens on the surface of cultured cells. Bernabeu, C., van de Rijn, M., Lerch, P.G., Terhorst, C.P. Nature (1984) [Pubmed]
  8. Receptor-mediated uptake of antigen/heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways. Castellino, F., Boucher, P.E., Eichelberg, K., Mayhew, M., Rothman, J.E., Houghton, A.N., Germain, R.N. J. Exp. Med. (2000) [Pubmed]
  9. Transporters associated with antigen processing (TAP)-independent presentation of soluble insulin to alpha/beta T cells by the class Ib gene product, Qa-1(b). Tompkins, S.M., Kraft, J.R., Dao, C.T., Soloski, M.J., Jensen, P.E. J. Exp. Med. (1998) [Pubmed]
  10. Quinolone-photoconjugated major histocompatibility complex class II-binding peptides with lysine are antigenic for T cells mediating murine quinolone photoallergy. Tokura, Y., Seo, N., Fujie, M., Takigawa, M. J. Invest. Dermatol. (2001) [Pubmed]
  11. Cross-reactive trinitrophenylated peptides as antigens for class II major histocompatibility complex-restricted T cells and inducers of contact sensitivity in mice. Limited T cell receptor repertoire. Kohler, J., Martin, S., Pflugfelder, U., Ruh, H., Vollmer, J., Weltzien, H.U. Eur. J. Immunol. (1995) [Pubmed]
  12. Recombinant DRB sequences produced by mismatch repair of heteroduplexes during cloning in Escherichia coli. Longeri, M., Zanotti, M., Damiani, G. Eur. J. Immunogenet. (2002) [Pubmed]
  13. The effect of lipopolysaccharide on bovine mammary macrophage function. Politis, I., Zhao, X., McBride, B.W., Burton, J.H. Can. J. Vet. Res. (1991) [Pubmed]
  14. The expression of anti-poly(LGlu60, LPhe40) idiotypic determinants dictated by the gene products in the major histocompatibility complex. Babu, U.M., Maurer, P.H. J. Exp. Med. (1981) [Pubmed]
  15. Specific suppression of major histocompatibility complex class I and class II genes in astrocytes by brain-enriched gangliosides. Massa, P.T. J. Exp. Med. (1993) [Pubmed]
  16. The collaborative phenotype of secondary B cells is determined by T lymphocytes during in vivo immunization. Speck, N.A., Pierce, S.K. J. Exp. Med. (1982) [Pubmed]
  17. YB-1 DNA-binding protein represses interferon gamma activation of class II major histocompatibility complex genes. Ting, J.P., Painter, A., Zeleznik-Le, N.J., MacDonald, G., Moore, T.M., Brown, A., Schwartz, B.D. J. Exp. Med. (1994) [Pubmed]
  18. Activated T lymphocytes produce a matrix-degrading heparan sulphate endoglycosidase. Naparstek, Y., Cohen, I.R., Fuks, Z., Vlodavsky, I. Nature (1984) [Pubmed]
  19. Major histocompatibility complex class II compartments in human B lymphoblastoid cells are distinct from early endosomes. Peters, P.J., Raposo, G., Neefjes, J.J., Oorschot, V., Leijendekker, R.L., Geuze, H.J., Ploegh, H.L. J. Exp. Med. (1995) [Pubmed]
  20. Selective release of some invariant chain-derived peptides from HLA-DR1 molecules at endosomal pH. Urban, R.G., Chicz, R.M., Strominger, J.L. J. Exp. Med. (1994) [Pubmed]
  21. Antigen capture and major histocompatibility class II compartments of freshly isolated and cultured human blood dendritic cells. Nijman, H.W., Kleijmeer, M.J., Ossevoort, M.A., Oorschot, V.M., Vierboom, M.P., van de Keur, M., Kenemans, P., Kast, W.M., Geuze, H.J., Melief, C.J. J. Exp. Med. (1995) [Pubmed]
  22. Low major histocompatibility complex class II diversity in European and North American moose. Mikko, S., Andersson, L. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  23. Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex. Pham-Dinh, D., Mattei, M.G., Nussbaum, J.L., Roussel, G., Pontarotti, P., Roeckel, N., Mather, I.H., Artzt, K., Lindahl, K.F., Dautigny, A. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  24. Mapping of steroid 21-hydroxylase genes adjacent to complement component C4 genes in HLA, the major histocompatibility complex in man. Carroll, M.C., Campbell, R.D., Porter, R.R. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  25. Autocrine induction of major histocompatibility complex class I antigen expression results from induction of beta interferon in oncogene-transformed BALB/c-3T3 cells. Offermann, M.K., Faller, D.V. Mol. Cell. Biol. (1989) [Pubmed]
  26. Afferent lymph veiled cells prime CD4+ T cell responses in vivo. McKeever, D.J., Awino, E., Morrison, W.I. Eur. J. Immunol. (1992) [Pubmed]
  27. Immunoregulatory roles of interleukin-13 in cattle. Trigona, W.L., Hirano, A., Brown, W.C., Estes, D.M. J. Interferon Cytokine Res. (1999) [Pubmed]
  28. Evidence for expression of both classical and non-classical major histocompatibility complex class I genes in bovine trophoblast cells. Davies, C.J., Eldridge, J.A., Fisher, P.J., Schlafer, D.H. Am. J. Reprod. Immunol. (2006) [Pubmed]
  29. Three-dimensional structure of beta 2-microglobulin. Becker, J.W., Reeke, G.N. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  30. The bovine major histocompatibility complex (BoLa): close linkage of the genes controlling serologically defined antigens and mixed lymphocyte reactivity. Usinger, W.R., Curie-Cohen, M., Benforado, K., Pringnitz, D., Rowe, R., Splitter, G.A., Stone, W.H. Immunogenetics (1981) [Pubmed]
  31. Deletion of one of the duplicated Hsp70 genes causes hereditary myopathy of diaphragmatic muscles in Holstein-Friesian cattle. Sugimoto, M., Furuoka, H., Sugimoto, Y. Anim. Genet. (2003) [Pubmed]
  32. Comparative organization and function of the major histocompatibility complex of domesticated cattle. Lewin, H.A., Russell, G.C., Glass, E.J. Immunol. Rev. (1999) [Pubmed]
  33. Variation in the number of expressed MHC genes in different cattle class I haplotypes. Ellis, S.A., Holmes, E.C., Staines, K.A., Smith, K.B., Stear, M.J., McKeever, D.J., MacHugh, N.D., Morrison, W.I. Immunogenetics (1999) [Pubmed]
  34. Isoelectric focusing of bovine major histocompatibility complex class II molecules. Watkins, D.I., Shadduck, J.A., Rudd, C.E., Stone, M.E., Lewin, H.A., Letvin, N.L. Eur. J. Immunol. (1989) [Pubmed]
  35. Bovine polymorphonuclear cells passively acquire membrane lipids and integral membrane proteins from apoptotic and necrotic cells. Whale, T.A., Beskorwayne, T.K., Babiuk, L.A., Griebel, P.J. J. Leukoc. Biol. (2006) [Pubmed]
  36. Interleukin-12 prevents severe acute graft-versus-host disease (GVHD) and GVHD-associated immune dysfunction in a fully major histocompatibility complex haplotype-mismatched murine bone marrow transplantation model. Yang, Y.G., Dey, B., Sergio, J.J., Sykes, M. Transplantation (1997) [Pubmed]
  37. Analysis of the major histocompatibility complex in Syrian hamsters. I. Skin graft rejection, graft-versus-host reactions, mixed lymphocyte reactions, and immune response genes in inbred strains. Duncan, W.R., Streilein, J.W. Transplantation (1978) [Pubmed]
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