High impact information on Satellite Cells, Skeletal Muscle

• Pax7 is required for the specification of myogenic satellite cells [1].
• Cultured primary myogenic satellite cells (MSCs) from TIS7(-/-) mice displayed marked reductions in differentiation potential and fusion index in a strictly cell-autonomous fashion [2].
• Inhibition of HSPG sulfation by treatment of intact myofibers with chlorate results in delayed proliferation and altered MyoD expression, demonstrating that heparan sulfate is required for proper progression of the early satellite cell myogenic program [3].
• Modulation of activities and RNA level of the components of the plasminogen activation system during fusion of human myogenic satellite cells in vitro [4].
• Fibroblast growth factor, epidermal growth factor, insulin-like growth factors, and platelet-derived growth factor-BB stimulate proliferation of clonally derived porcine myogenic satellite cells [5].

Biological context of Satellite Cells, Skeletal Muscle

• In this study, primary cultures of ovine myogenic satellite cells were evaluated for their ability to use peptide-bound methionine as a source of methionine for protein accretion and cell proliferation [6].
• We show that down-regulation of caveolin-1 expression occurs in satellite cells/myogenic precursor cells (MPCs) during muscle regeneration and that hepatocyte growth factor, which is produced after muscle injury, down-regulates caveolin-1 [7].

Anatomical context of Satellite Cells, Skeletal Muscle

• To compare the effects of PDGF during different developmental stages, postnatal myogenic satellite cell and embryonic myoblast cultures were developed for in vitro comparisons [8].

Associations of Satellite Cells, Skeletal Muscle with chemical compounds

• CONCLUSIONS: Creatine in the monohydrate form induced differentiation of myogenic satellite cells [9].
• Normal and LSN myogenic satellite cell cultures did not express the beta1D integrin, but the LSN satellite cells expressed higher concentrations of the beta1A integrin than did normal satellite cells [10].
• Myogenic satellite cells were isolated from nondiabetic and streptozotocin-diabetic rats and studied in vitro [11].

Gene context of Satellite Cells, Skeletal Muscle

• Furthermore, as myogenic satellite cells are known to express PAX7, this pattern of PAX7 expression suggests this cell type as the origin of these tumours [12].
• Expression of insulin-like growth factor II (IGF-II), IGF binding protein-2 and myogenin during differentiation of myogenic satellite cells derived from the turkey [13].
• In the current study, males and females of a turkey genetic line selected only for increased 16-wk BW (F line) and an unselected randombred control (RBC2 line) from which the F line was developed were used to investigate the developmental expression of MyoD and myogenin mRNA in embryonic pectoralis major muscle and myogenic satellite cells [14].
• In the current study, expression vector constructs containing either syndecan-1 or glypican were transfected into turkey myogenic satellite cells resulting in the overexpression of these genes [15].
• In myogenic satellite cells, initiating differentiation resulted in a decrease in SYN 2 expression and an increase in GPC 1 expression [16].

References