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MeSH Review

Myocytes, Smooth Muscle

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Disease relevance of Myocytes, Smooth Muscle


High impact information on Myocytes, Smooth Muscle

  • Nitric oxide is a potent endothelium-derived vasorelaxant substance and an inhibitor of smooth-muscle-cell growth [2].
  • SB-267268 inhibited the attachment of alpha(v)beta3-transfected HEK293 cells to microtiter plate wells precoated with RGD-containing matrix proteins, and vitronectin-mediated human and rat aortic smooth-muscle-cell migration [3].
  • BACKGROUND: Statins and angiotensin II type I receptor blockers have synergistic effects on vascular smooth-muscle-cell proliferation and the progression of renal diseases [4].
  • Thrombospondin 1 does not activate transforming growth factor beta1 in a chemically defined system or in smooth-muscle-cell cultures [5].
  • Smooth-muscle-cell (SMC) replication and extracellular matrix protein expression are two vital and interrelated processes necessary for normal development of the vasculature [6].

Anatomical context of Myocytes, Smooth Muscle


Associations of Myocytes, Smooth Muscle with chemical compounds

  • In contrast with endothelial ecto-5'-nucleotidase, the smooth-muscle-cell enzyme catabolized adenosine 5'-monophosphorothioate (AMPS) to adenosine: the affinity of the enzyme for AMPS was greater than for AMP, and Vmax for AMPS was about one-sixth that for AMP [11].
  • In vitro, heparin (10 and 100 U x kg-1 x ml-1) increased cGMP levels after 10 min and 24 h in N and anoxic (0% O2) endothelial cell-smooth muscle cell (SMC) coculture [12].

Gene context of Myocytes, Smooth Muscle


  1. Antenatal dexamethasone administration inhibits smooth-muscle-cell DNA synthesis in pulmonary-arterial media in nitrofen-induced congenital diaphragmatic hernia in rats. Taira, Y., Shima, H., Miyazaki, E., Ohshiro, K., Puri, P. Pediatr. Surg. Int. (2000) [Pubmed]
  2. Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. Giaid, A., Saleh, D. N. Engl. J. Med. (1995) [Pubmed]
  3. SB-267268, a nonpeptidic antagonist of alpha(v)beta3 and alpha(v)beta5 integrins, reduces angiogenesis and VEGF expression in a mouse model of retinopathy of prematurity. Wilkinson-Berka, J.L., Jones, D., Taylor, G., Jaworski, K., Kelly, D.J., Ludbrook, S.B., Willette, R.N., Kumar, S., Gilbert, R.E. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  4. Combined effects of losartan and pravastatin on interstitial inflammation and fibrosis in chronic cyclosporine-induced nephropathy. Li, C., Sun, B.K., Lim, S.W., Song, J.C., Kang, S.W., Kim, Y.S., Kang, D.H., Cha, J.H., Kim, J., Yang, C.W. Transplantation (2005) [Pubmed]
  5. Thrombospondin 1 does not activate transforming growth factor beta1 in a chemically defined system or in smooth-muscle-cell cultures. Grainger, D.J., Frow, E.K. Biochem. J. (2000) [Pubmed]
  6. Relationship between perlecan and tropoelastin gene expression and cell replication in the developing rat pulmonary vasculature. Belknap, J.K., Weiser-Evans, M.C., Grieshaber, S.S., Majack, R.A., Stenmark, K.R. Am. J. Respir. Cell Mol. Biol. (1999) [Pubmed]
  7. Regulation of secretion and clearance of C-type natriuretic peptide in the interaction of vascular endothelial cells and smooth muscle cells. Komatsu, Y., Itoh, H., Suga, S., Igaki, T., Ogawa, Y., Kishimoto, I., Nakagawa, O., Yoshimasa, T., Nakao, K. J. Hypertens. (1996) [Pubmed]
  8. Modulation of neuroblastoma cell differentiation by the extracellular matrix. Matsushima, H., Bogenmann, E. Int. J. Cancer (1992) [Pubmed]
  9. Chronic rejection in the rat aortic allograft. V. Mechanism of the angiopeptin (BIM23014C) effect on the generation of allograft arteriosclerosis. Mennander, A., Räisänen, A., Paavonen, T., Häyry, P. Transplantation (1993) [Pubmed]
  10. Immunochemical identification of human endothelial cells on the lining of a ventricular assist device. Frazier, O.H., Baldwin, R.T., Eskin, S.G., Duncan, J.M. Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital. (1993) [Pubmed]
  11. Characterization of ectonucleotidases on vascular smooth-muscle cells. Pearson, J.D., Coade, S.B., Cusack, N.J. Biochem. J. (1985) [Pubmed]
  12. Role of nitric oxide in heparin-induced attenuation of hypoxic pulmonary vascular remodeling. Horstman, D.J., Fischer, L.G., Kouretas, P.C., Hannan, R.L., Rich, G.F. J. Appl. Physiol. (2002) [Pubmed]
  13. Production and inhibition of the gelatinolytic matrix metalloproteinases in a human model of vein graft stenosis. Porter, K.E., Thompson, M.M., Loftus, I.M., McDermott, E., Jones, L., Crowther, M., Bell, P.R., London, N.J. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. (1999) [Pubmed]
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