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Gene Review

LOC313641  -  perlecan

Rattus norvegicus

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Disease relevance of LOC313641


Psychiatry related information on LOC313641


High impact information on LOC313641


Biological context of LOC313641


Anatomical context of LOC313641


Associations of LOC313641 with chemical compounds


Physical interactions of LOC313641


Regulatory relationships of LOC313641


Other interactions of LOC313641

  • AngII treatment also resulted in significant increases in the mRNA of the core proteins, versican, biglycan, and perlecan [18].
  • To identify the EHS-BM component involved in the active repression of Oct-1 mRNA expression, SMCs were plated on laminin, type IV collagen, fibronectin, or perlecan matrices [6].
  • Chronic liver damage was characterized by the deposition of decorin and perlecan in the fibrotic septa [11].
  • Therefore, we concluded that the alveolar epithelial cells synthesize laminin-1, entactin, type IV collagen, and perlecan, but that they also needed to assemble exogenous laminin-1 into the basement membrane to complete its formation in vitro [19].
  • We first determined that rat AECs secrete an extracellular matrix (ECM) rich in anastamosing fibers composed of the alpha3 laminin subunit, complexed with beta1 and gamma1 laminin subunits (i.e. laminin-6), and perlecan by a combination of immunofluorescence microscopy and immunoblotting analyses [7].

Analytical, diagnostic and therapeutic context of LOC313641


  1. Perlecan is a component of cartilage matrix and promotes chondrocyte attachment. SundarRaj, N., Fite, D., Ledbetter, S., Chakravarti, S., Hassell, J.R. J. Cell. Sci. (1995) [Pubmed]
  2. Treatment with a glycosaminoglycan formulation ameliorates experimental diabetic nephropathy. Gambaro, G., Venturini, A.P., Noonan, D.M., Fries, W., Re, G., Garbisa, S., Milanesi, C., Pesarini, A., Borsatti, A., Marchi, E. Kidney Int. (1994) [Pubmed]
  3. A beta and perlecan in rat brain: glial activation, gradual clearance and limited neurotoxicity. Holcomb, L.A., Gordon, M.N., Benkovic, S.A., Morgan, D.G. Mech. Ageing Dev. (2000) [Pubmed]
  4. cDNA cloning of the basement membrane chondroitin sulfate proteoglycan core protein, bamacan: a five domain structure including coiled-coil motifs. Wu, R.R., Couchman, J.R. J. Cell Biol. (1997) [Pubmed]
  5. Antibody response against perlecan and collagen types IV and VI in chronic renal allograft rejection in the rat. Joosten, S.A., van Dixhoorn, M.G., Borrias, M.C., Benediktsson, H., van Veelen, P.A., van Kooten, C., Paul, L.C. Am. J. Pathol. (2002) [Pubmed]
  6. Perlecan regulates Oct-1 gene expression in vascular smooth muscle cells. Weiser, M.C., Grieshaber, N.A., Schwartz, P.E., Majack, R.A. Mol. Biol. Cell (1997) [Pubmed]
  7. Laminin-6 assembles into multimolecular fibrillar complexes with perlecan and participates in mechanical-signal transduction via a dystroglycan-dependent, integrin-independent mechanism. Jones, J.C., Lane, K., Hopkinson, S.B., Lecuona, E., Geiger, R.C., Dean, D.A., Correa-Meyer, E., Gonzales, M., Campbell, K., Sznajder, J.I., Budinger, S. J. Cell. Sci. (2005) [Pubmed]
  8. The beta-amyloid peptide of Alzheimer's disease decreases adhesion of vascular smooth muscle cells to the basement membrane. Mok, S.S., Losic, D., Barrow, C.J., Turner, B.J., Masters, C.L., Martin, L.L., Small, D.H. J. Neurochem. (2006) [Pubmed]
  9. Developmental regulation of perlecan gene expression in aortic smooth muscle cells. Weiser, M.C., Belknap, J.K., Grieshaber, S.S., Kinsella, M.G., Majack, R.A. Matrix Biol. (1996) [Pubmed]
  10. Distribution and origin of the basement membrane component perlecan in rat liver and primary hepatocyte culture. Rescan, P.Y., Loréal, O., Hassell, J.R., Yamada, Y., Guillouzo, A., Clément, B. Am. J. Pathol. (1993) [Pubmed]
  11. Expression of extracellular matrix proteoglycans perlecan and decorin in carbon-tetrachloride-injured rat liver and in isolated liver cells. Gallai, M., Kovalszky, I., Knittel, T., Neubauer, K., Armbrust, T., Ramadori, G. Am. J. Pathol. (1996) [Pubmed]
  12. Smooth muscle cell expression of extracellular matrix genes after arterial injury. Nikkari, S.T., Järveläinen, H.T., Wight, T.N., Ferguson, M., Clowes, A.W. Am. J. Pathol. (1994) [Pubmed]
  13. A steady-state labelling approach to the measurement of proteoglycan turnover in vivo and its application to glomerular proteoglycans. Akuffo, E.L., Hunt, J.R., Moss, J., Woodrow, D., Davies, M., Mason, R.M. Biochem. J. (1996) [Pubmed]
  14. Posttranscriptional effects of glucose on proteoglycan expression in mesangial cells. Templeton, D.M., Fan, M.Y. Metab. Clin. Exp. (1996) [Pubmed]
  15. Heparan sulfate proteoglycan synthesis and its expression are decreased in the retina of diabetic rats. Bollineni, J.S., Alluru, I., Reddi, A.S. Curr. Eye Res. (1997) [Pubmed]
  16. Basic fibroblast growth factor in the primary olfactory pathway: mitogenic effect on ensheathing cells. Chuah, M.I., Teague, R. Neuroscience (1999) [Pubmed]
  17. Syndecan-3 and perlecan are differentially expressed by progenitors and mature oligodendrocytes and accumulate in the extracellular matrix. Winkler, S., Stahl, R.C., Carey, D.J., Bansal, R. J. Neurosci. Res. (2002) [Pubmed]
  18. Regulation of vascular proteoglycan synthesis by angiotensin II type 1 and type 2 receptors. Shimizu-Hirota, R., Sasamura, H., Mifune, M., Nakaya, H., Kuroda, M., Hayashi, M., Saruta, T. J. Am. Soc. Nephrol. (2001) [Pubmed]
  19. Assembly of the exogenous extracellular matrix during basement membrane formation by alveolar epithelial cells in vitro. Furuyama, A., Mochitate, K. J. Cell. Sci. (2000) [Pubmed]
  20. Rat mesangial cells in vitro synthesize a spectrum of proteoglycan species including those of the basement membrane and interstitium. Thomas, G.J., Shewring, L., McCarthy, K.J., Couchman, J.R., Mason, R.M., Davies, M. Kidney Int. (1995) [Pubmed]
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