Disease relevance of Ammi

• Khellin, a naturally occurring furanochromone (Ammi visnaga fruits), inhibited the mutagenicity of the promutagens benzo[a]pyrene, 2-aminofluorene and 2-aminoanthracene in Salmonella typhimurium TA98 [1].
• Inhibition of oxalate nephrolithiasis with Ammi visnaga (AI-Khillah) [2].
• Effect of Trigonella foenum-graecum and Ammi majus on calcium oxalate urolithiasis in rats [3].

High impact information on Ammi

• Caffeoyl-coenzyme A O-methyltransferase cDNA was cloned from dark-grown Ammi majus L [4].
• Microsomes prepared from cultured Ammi majus cells that had been challenged for 14 h with an elicitor derived from the cell walls of Phytophthora megasperma f.sp. glycinea (Pmg) converted psoralen to bergaptol (5-hydroxypsoralen) in the presence of NADPH and oxygen [5].
• Ammi visnaga fruits were extracted with methanol and the extracts were directly injected without any purification and pre-separation processes [6].
• Functional expression of cinnamate 4-hydroxylase from Ammi majus L [7].
• Acetylated flavonol triglycosides from Ammi majus L [8].

Associations of Ammi with chemical compounds

• Induction of two prenyltransferases for the accumulation of coumarin phytoalexins in elicitor-treated Ammi majus cell suspension cultures [9].
• Alloimperatorin from Ammi majus fruits. Natural coumarins, part XX [10].
• Two dimethylallyl diphosphate:umbelliferone dimethylallyltransferase (prenyltransferase) activities, catalysing the 6-prenylation and the 7-O-prenylation, respectively, of umbelliferone in the course of phytoalexin synthesis, increased in Ammi majus cell suspension cultures in response to elicitor treatment [9].
• The extract from Ammi visnaga fruits showed a higher inhibition potency than khellin alone against 2-aminoanthracene, 1-nitropyrene and daunomycin [1].
• Hypoglycemic effect of aqueous extract of Ammi visnaga in normal and streptozotocin-induced diabetic rats [11].

Gene context of Ammi

• Already in ancient Egypt, vitiligo lesions were treated with extracts of the Ammi maius plant followed by exposure to the sun [12].

References